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손미영 교수

MI-YOUNG SON

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4426
  • 출신전공생명과학과 (줄기세포학)
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일

연구분야

줄기세포 기반 3차원 오가노이드 연구 및 질환 모델링

Study of stem cell-based organoids & disease modeling

대표연구실적

-  Jung KB, Kwon O, Lee MO, Lee H, Son YS, Habib O, Oh JH, Cho HS, Jung CR, Kim J, Son MY. Blockade of STAT3 causes severe in vitro and in vivo maturation defects in intestinal organoids derived from human embryonic stem cells. Journal Clinical Medicine 2019 Jul 4;8(7). (Corresponding author) -  Lee MO, Jung KB, Jo SJ, Hyun SA, Moon KS, Seo JW, Kim SH, Son MY. Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. Journal of Biological Engineering 2019 Feb 13;13:15. (Corresponding author) -  Jung KB, Lee H, Son YS, Lee MO, Kim YD, Oh SJ, Kwon O, Cho S, Cho HS, Kim DS, Oh JH, Zilbauer M, Min JK, Jung CR, Kim JH, Son MY. Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids. Nature Communications 2018 Aug 2;9(1):3039. (Corresponding author)

논문(최근 5년)

-  Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency[HUMAN MOLECULAR GENETICS,2014-04-01] -  Biochemical and molecular characterization of novel mutations in GLB1 and NEU1 in patient cells with lysosomal storage disorders. [ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-02-20] -  Proteomic and network analysis of proteins regulated by REX1 in human embryonic stem cells. Proteomics[PROTEOMICS,2015-07-15] -  A novel human model of neurodegenerative disease GM1 gangliosidosis using iPSCs demonstrates inflammasome activation[ JOURNAL OF PATHOLOGY,2015-09-01] -  Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency[ CELL DEATH AND DIFFERENTIATION,2015-04-17] -  Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles[ TOXICOLOGY AND APPLIED PHARMACOLOGY,2016-05-15] -  Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-05-13] -  Pro-fibrotic effects of PFKFB4-mediated glycolytic reprogramming in fibrous dysplasia[ BIOMATERIALS,2016-11-01] -  Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease[PLOS ONE,2015-08-28] -  Biomarker discovery by modeling Behcet’s disease with patient-specific human induced pluripotent stem cells[ STEM CELLS AND DEVELOPMENT,2017-01-15] -  Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells[NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,2017-12-01] -  The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN[ STEM CELL RESEARCH,2017-05-30] -  Transcriptome dynamics of human pluripotent stem cell-1 derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum[ MOLECULAR BIOSYSTEMS,2017-07-25] -  Clump-passaging-based efficient 3D culture of human pluripotent stem cells under chemically defined conditions[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-11-04] -  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models[ HEPATOLOGY,2017-11-01] -  In vitro and in vivo imaging and tracking of intestinal organoids from human induced pluripotent stem cells[ FASEB JOURNAL,2018-01-01] -  Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC[ ONCOTARGET,2017-12-14] -  EHMT2 is a metastasis regulator in breast cancer[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018-02-05] -  Comparative analysis of human embryonic stem cell-derived neural stem cells as an in vitro human model[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-02-01] -  Comparative in silico profiling of epigenetic modifiers in human tissues[MOLECULAR BIOLOGY REPORTS,2018-06-01] -  Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.[NATURE COMMUNICATIONS,2018-08-02] -  The novel prognostic marker EHMT2 is involved in cell proliferation via HSPD1 regulation in breast cancer[INTERNATIONAL JOURNAL OF ONCOLOGY,2019-01-01] -  SETDB1 regulates SMAD7 expression for breast cancer metastasis.[BMB REPORTS,2019-02-01] -  Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells[JOURNAL OF BIOLOGICAL ENGINEERING,2019-02-13]

특허(최근 5년)

-  REX1을 포함하는 세포 리프로그래밍 조성물 및 이를 이용한 유도만능줄기세포 제조방법[2014-03-14] -  줄기세포로부터 생성된 배아체를 대량 증식 및 유지하는 방법 [2015-03-24] -  다능성 줄기세포의 제작, 유지, 증식을 증진하는 대사산물 및 이를 포함하는 조성물과 배양방법 [2016-09-05] -  베체트병의 인간 세포 모델 및 이의 용도[2016-11-24] -  GM1 강글리오시드증의 인간 세포 모델 및 이의 용도 [2017-05-17] -  베체트병의 인간 세포 모델 및 이의 용도 [2017-03-29] -  뮤코지질증 인간 세포 모델 및 이의 용도 [2017-10-02] -  세포 스페로이드 배양기를 포함하는 세포 스페로이드 배양 시스템 [2017-05-29] -  조직 간 유사성 및 분화 수준에 대한 정보 제공 방법[2018-11-15] -  A METHOD FOR TREATMENT OF GM1 GANGLIOSIDOSIS[2018-07-31]

연구과제 수행 실적

3차원 오가노이드 기술을 통한 인체 모방 기능성 장관모델 개발 혈관화된 3차원 생체조직 (간/심장, 암) 모사 칩 기반 약물 효능 및 독성 평가 시스템의 개발 인간 장관모델 기반 마이크로바이옴 연구 플랫폼 구축 및 활용기술 개발