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CHO, HYUN-SOO

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8152
  • 출신전공분자세포생물학
  • 학위박사
  • 최종출신대학University of Tokyo
  • 이메일

연구분야

암 특이적 히스톤 메칠화/ 탈메칠화 효소에 관한 연구

Development of a new cancer therapy targeting histone methyltransferases and demethylases.

대표연구실적

-  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models. Hepatology. 2017 Nov;66(5):1662-1674 -  Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression. Cancer Res. 2012 Jul 1;72(13):3217-3227 -  Enhanced HSP70 lysine 561 methylation promotes proliferation of cancer cells through activation of aurora kinase B. Nat Commun. 2012;3:1072.

논문(최근 5년)

-  Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7?TIPRL in human hepatocellular carcinoma cells[Oncology Reports,2014-07-23] -  WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck[Molecular Cancer Research,2015-03-01] -  Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells[Molecular Carcinogenesis,2015-03-01] -  IFT46 plays an essential role in cilia development[DEVELOPMENTAL BIOLOGY,2015-04-15] -  SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells[Oncotarget,2015-12-22] -  Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells[Oncotarget,2015-09-15] -  Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis[Oncotarget,2016-11-29] -  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models[HEPATOLOGY,2017-06-22] -  Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo[SCIENTIFIC REPORTS,2017-09-05] -  Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in hepatocellular carcinoma[Oncotarget,2017-11-03] -  Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC[Oncotarget,2017-12-14] -  In vitro and in vivo imaging and tracking of intestinal organoids from human induced pluripotent stem cells[FASEB JOURNAL,2018-01-06] -  Bioinformatic analysis of regulation of natural antisense transcripts by transposable elements in human mRNA[GENOMICS,2018-01-20] -  EHMT2 is a metastasis regulator in breast cancer.[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018-01-11]

연구과제 수행 실적

NGS기반 암형성/전이 관련 신규 히스톤메칠화 효소 도출 및 치료제 개발로의 활용 NOCS 및 장기유사체의 생체유사도 검증 평가 시스템 구축