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오경진 교수

Kyoung-Jin Oh

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8265
  • 출신전공분자세포생물학
  • 학위박사
  • 최종출신대학성균관대학교 자연과학캠퍼스
  • 이메일

연구분야

제 2형 당뇨 및 비만에서 인슐린 신호전달체계와 에너지 대사 규명 및 제어 연구

Glucose/lipid metabolism and insulin resistance in type 2 diabetes and obesity

대표연구실적

-  Dongryeol Ryu*, Kyoung-Jin Oh*, Hee-Yeon Jo, Susan Hedrick, Yo-Na Kim, Yu-Jin Hwang, Tae-Sik Park, Joong-Soo Han, Cheol Soo Choi, Marc Montminy and Seung-Hoi Koo. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metabolism. 2009 Mar;9(3):240-251. (*Co-first authors) -  Dahee Choi*, Kyoung-Jin Oh*, Hye Sook Han, Young-Sil Yoon, Sang-Yoon Choi, Seong-Tae Kim and Seung-Hoi Koo. Protein arginine methyltransferase-1 regulates hepatic glucose production in a FoxO1 dependent manner. Hepatology. 2012 Oct;56 (4):1546-56. (*Co-first authors) -  Kyoung-Jin Oh, Jinyoung Park, Su Sung Kim, Hyunhee Oh, Cheol Soo Choi and Seung-Hoi Koo. TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver. PLoS Genet. 2012 Sep;8(9): e1002986.

논문(최근 5년)

-  Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX. [ MOLECULES AND CELLS,2014-09-29] -  Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer. [CELL DEATH & DISEASE,2015-01-22] -  DUSP4 regulates neuronal differentiation and calcium homeostasis by modulating ERK1/2 phosphorylation. [ STEM CELLS AND DEVELOPMENT,2015-03-15] -  Recent advances in proteomic studies of adipose tissues and adipocytes.[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-02-27] -  MAP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation.[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2015-11-15] -  Silica nanoparticles inhibit brown adipocyte differentiation via regulation of p38 phosphorylation.[ NANOTECHNOLOGY,2015-10-30] -  Profiling analysis of protein tyrosine phosphatases during neuronal differentiation.[ NEUROSCIENCE LETTERS,2016-01-26] -  Insulin-inducible SMILE inhibits hepatic gluconeogenesis. [ DIABETES,2016-01-01] -  c-Jun regulates adipocyte differentiation via the KLF15-mediated mode. [ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-01-15] -  Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM2, a subunit of ESCRT-0. [PLOS ONE,2016-02-11] -  Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation.[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-08-15] -  Small molecules facilitate single factor-mediated hepatic reprogramming[Cell Reports,2016-04-26] -  Methyltransferase and demethylase profiling studies during brown adipocyte differentiation.[BMB REPORTS,2016-05-09] -  Effect of BI-1 on insulin resistance through regulation of CYP2E1. [SCIENTIFIC REPORTS,2016-08-31] -  Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016-12-22] -  Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase. [ARCHIVES OF VIROLOGY,2017-11-01] -  HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription.[MOLECULES AND CELLS,2017-09-30] -  Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation. [NATURE COMMUNICATIONS,2018-08-24]

특허(최근 5년)

-  지각 추출물 및 콜레우스 포스콜리 추출물을 유효성분으로 함유하는 비만 예방 또는 개선용 건강기능식품[2018-10-17]

연구과제 수행 실적

근육과 간에서의 당뇨 유전자 TCF7L2의 역할 규명 대사네트워크 규명을 통한 대사질환제어 기술개발