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Byoung Mog Kwon(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Bio-Molecular Science)
  • Contact Information042-860-4557
  • Major화학 및 생화학과
  • DegreePh.D.
  • Highest Level of EducationUniversity of California, Los Angeles
  • E-Mail

Field of Research

Chemical Genomics, Chemical Biology, Anti-tumor Drug Discovery, Natural Product

Research Results

-  Kim, K. H., Kwon, B. M., Myers, A. G.,* and Rees, D. C. "Crystal Structure of Neocarzinostatin, an Antitumor Protein-Chromophore Complex" Science, 1993, 262, 1042-1046. -  Han, D. C., Lee, M. Y., Shin, K. D., Kim, J. M., Son, K. H., Kim, H. J., Kim, H. M., Kwon, B. M. "2-Benzoyloxycinnamaldehyde induces apoptosis in Human carcinoma via reactive oxygen species" J. Biol. Chem. 2004, 279, 6911-6920. -  Shin, D. S.; Kim, H. N.; Shin, K. D.; Yoon, Y. J.; Kim, S. J. Han, D. C.; Kwon, B. M. "Cryptotanshinone inhibits constitutive STAT3 function through blocking the dimerization in DU145 prostate cancer cells" Cancer Research 2009, 69, 193-202.

Treatise

-  EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer[Cancer Lettwrs,2014-07-10] -  LRP1-dependent pepsin clearance induced by2-hydroxycinnamaldehyde attenuates breast cancer cell invasion[International Journal of Biochemistry & Cell Biology,2014-08-15] -  Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3[Biochemical Pharmacology,2014-05-15] -  Dual pH-sensitive oxidative stress generating micellar nanoparticles as a novel anticancer therapeutic agent[JOURNAL OF CONTROLLED RELEASE,2014-10-11] -  Ginkgetin inhibits the growth of DU­145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity[CANCER SCIENCE,2015-04-10] -  Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells[PHYTOTHERAPY RESEARCH,2015-05-05] -  Fisetin a dietary flavonoid induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter[CARCINOGENESIS,2015-06-11] -  Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells[BIOCHEMICAL PHARMACOLOGY,2015-09-01] -  Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition[EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015-09-10] -  Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling[ CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2015-03-26] -  Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b?Myb and miRNA34a expression[ INTERNATIONAL JOURNAL OF ONCOLOGY,2017-10-05] -  Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase[ BIOCHEMICAL PHARMACOLOGY,2017-10-15] -  An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-05-05] -  PPARγ agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARγ phosphatase[ INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2016-12-08] -  Cinnamaldehydes in Cancer Chemotherapy[ PHYTOTHERAPY RESEARCH,2016-05-30] -  Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents[ ACS APPLIED MATERIALS & INTERFACES,2016-03-06] -  Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor[ ONCOLOGY LETTERS,2017-10-10]

Patent

-  Composition comprising benproperine derivatives as active ingredients for preventing and treating angiogenesis-related disease[2014-05-06] -  Indazole derivatives or pharmaceutically acceptable salts thereof protein kinase inhibitors for proliferative disease treatment and a pharmaceutical composition containing the same[2014-06-17] -  Composition for the Prevention or Treatment of Bone Diseases Comprising Colforsin Daropate[2015-03-31] -  벤조일옥시신남알데히드-폴리에틸렌글리콜 결합 마이셀에 아연 프로토포르피 린을 담지한 pH 감응형 항암 전구약물 및 이의 제조방법[2015-09-15] -  퀘시아 운둘라타의 추출물 또는 이의 분획물을 유효성분으로 함유하는 암 또는 암전이 억제용 약학적 조성물[2015-12-17] -  Composition comprising benproperine derivatives as active ingredients for preventing and treating angiogenesis-related disease[2016-02-05] -  Compositions for anti-Tumor comprising extract or fractions of Artocarpus altilis leaves or stem[2016-11-08] -  Compositions for anti-Tumor comprising extract or fractions of Artocarpus altilis leaves or stem[2016-08-12] -  A GERANYL FLAVONOID DERIVATIVE WITH IMPROVED WATER SOLUBILITY, [2017-02-28] -  신규한 2-하이드록시 커큐미노이드 유도체, 이의 제조 방법 및 이를 포함하는 항암제 조성물[2016-12-22] -  빵 나무의 추출물, 또는 이의 분획물을 유효성분으로 함유하는 암 예방 [2016-11-16] -  신남알데히드 및 퀴논 메티드를 동시에 생성하는 혼성 항암 전구약물 및 이의제조법[2016-11-16] -  아미노벤조에이트 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 골 질환 예방 및 [2016-11-15] -  신규한 신남-로다닌 유도체 및 이를 유효성분으로 포함하는 약학적 조성물[2016-05-30] -  피라졸 아마이드 화합물 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물[2016-02-29] -  물에 대한 용해도가 개선된 신규 제라닐 프라보노이드 유도체, 이의 제조 방법 및 이를 유효[2017-01-11]