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Lee Hee Gu(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Bio-Molecular Science)
  • Contact Information042-860-4182
  • Major면역학
  • DegreePh.D.
  • Highest Level of Education건국대학교
  • E-Mail

Field of Research

Functional research of disease-related biomarker and diagnostic development for therapeutic target molecules

Research Results

-  Collagen Triple Helix Repeat Containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells/Oncotarget/2014.02.21 -  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer/Oncotarget/2014.04.29 -  Cystatin SN neutralizes the inhibitory effect of cystatin C on cathepsin B activity/CELL DEATH & DISEASE/2013.12.30

Treatise

-  Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification[Oncotarget,2014-08-23] -  Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase C?-dependent sumoylation[Int J Biochem Cell Biol.,2014-08-29] -  Dephosphorylation of CCAAT/enhancer-binding protein β by protein phosphatase 2A containing B56δ is required at the early time of adipogenesis[Biochim Biophys Acta,2014-08-23] -  An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression[Hum Reprod,2014-10-10] -  NAD(P)H:Quinone Oxidoreductase 1 Activation Reduces Blood Pressure Through Regulation of Endothelial Nitric Oxide Synthase Acetylation in Spontaneously Hypertensive Rats[Am J Hypertens,2014-06-20] -  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer[Oncotarget,2014-04-30] -  Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation[ CELL DEATH & DISEASE,2017-03-07] -  Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer[ ONCOTARGET,2016-11-15] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer[Cell Death and Disease,2017-02-14] -  Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity[ NATURE COMMUNICATIONS,2016-12-08] -  Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function[ JOURNAL OF LEUKOCYTE BIOLOGY,2016-08-12] -  Tescalcin expression contributes to invasive and metastatic activity in colorectal cancer[ TUMOR BIOLOGY,2016-08-02] -  Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases[ ACTA BIOMATERIALIA,2016-09-14] -  Antimelanogenic effect of 4-hydroxylonchocarpin through the inhibition of tyrosinase-related proteins and MAPK phosphatase[ EXPERIMENTAL DERMATOLOGY,2016-02-26] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ ONCOTARGET,2016-01-27] -  Genkwadaphnin promotes leukocyte migration by increasing CD44 expression via PKD1/NF-κB signaling pathway[ IMMUNOLOGY LETTERS,2016-03-14] -  Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer[ ONCOTARGET,2015-12-10] -  Liposome-encapsulated CpG enhances antitumor activity accompanying the changing of lymphocyte populations in tumor via intratumoral administration[ NUCLEIC ACID THERAPEUTICS,2015-02-18] -  Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression[ JOURNAL OF HEPATOLOGY,2015-08-04] -  Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding[ NATURE CELL BIOLOGY,2015-06-15] -  Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma[ ONCOTARGET,2016-01-22] -  Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody[ BIOMATERIALS,2015-02-17]

Patent

-  감수(Euphobia kansui) 추출물, 분획물 또는 이로부터 분리한 디테르펜 화합물을 유효성분으로 하는, 상피세포의활성을유도하고상처회복에관여하는약학적조성물[2017-06-14] -  감수(Euphobia kansui) 추출물, 분획물 또는 이로부터 분리한 디테르펜 화합물을 유효성분으로 하는, 상피세포의활성을유도하고상처회복에관여하는약학적조성물[2017-06-14] -  신규한 GPCR 단백질 및 이의 용도[2015-11-04] -  신규한 GPCR 단백질 및 이의 용도[2015-11-04] -  감수(Euphobia kansui) 추출물, 분획물 또는 이로부터 분리한 디테르펜 화합물을 유효성분으로 하는, 상피세포의활성을유도하고상처회복에관여하는약학적조성물[2015-06-23] -  암 치료용 약학 조성물[2015-12-22] -  심혈관 질환 마커 파랄레민 및 이를 이용한 심혈관 질환 진단 방법[2016-01-21] -  신규한 GPCR 단백질 및 이의 용도[2017-03-01] -  칼리크레인6의 발현 또는 활성 억제제를 유효성분으로 함유하는 항암제 민감성 증진용 약학적 조성물[2016-03-16] -  인간 고아 G-단백질 결합 수용체 단백질의 효능제 및 저해제 탐색을 위한 HTS 시스템[2015-07-02] -  암 치료용 약학 조성물[2014-09-30] -  감수(Euphobia kansui) 추출물, 분획물 또는 이로부터 분리한 디테르펜 화합물을 유효성분으로 하는, 상피세포의활성을유도하고상처회복에관여하는약학적조성물[2015-03-19] -  신규한 GPCR 단백질 및 이의 용도[2014-09-03] -  신규한 GPCR 단백질 및 이의 용도[2015-07-24] -  암 진단을 위한 메틸화 바이오 마커 TESC 및 이의 용도[2014-06-24] -  인간 TESC 단백질에 특이적으로 결합하는 단일클론항체 및 이의 용도[2014-06-24] -  대장암 진단 키트 및 대장암의 예방 또는 치료용 약제학적 조성물[2017-08-31] -  위암 진단 마커로써의 CST1, DCC1, IFITM1 또는 MELK[2015-07-07]