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Lee, Chul-Ho(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Functional Genomics)
  • Contact Information042-860-4637
  • Major수의학과(예방)
  • DegreePh.D.
  • Highest Level of Education충남대학교
  • E-Mail

Field of Research

Disease animal model, Metabolic disease

Research Results

-  Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol -  Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis -  NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats

Treatise

-  Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPAR gamma agonist-induced adipogenesis[MOLECULES AND CELLS,2014-07-20] -  Pharmacological activation of NQO1 increases NAD(+) levels and attenuates cisplatin-mediated acute kidney injury in mice[KIDNEY INTERNATIONAL,2014-03-01] -  In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green[MAGNETIC RESONANCE IN MEDICINE,2014-03-01] -  New players in high fat diet-induced obesity: LETM1 and CTMP[METABOLISM-CLINICAL AND EXPERIMENTAL,2014-03-01] -  Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism[BRAIN RESEARCH,2014-03-13] -  Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis[NATURE MEDICINE,2014-04-01] -  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer[ONCOTARGET,2014-04-01] -  Enhanced Th2 cell differentiation and function in the absence of Nox2[ ALLERGY,2017-02-01] -  An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction[ BIOMATERIALS SCIENCE,2017-01-31] -  Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2017-01-02] -  Oleanane-type triterpenoids of Aceriphyllum rossii and their diacylglycerol acyltransferase-inhibitory activity[ PLANTA MEDICA,2015-03-02] -  Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome[NATURE COMMUNICATIONS,2015-02-06] -  Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury[ MOLECULES AND CELLS,2015-10-01] -  The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation[ LIVER INTERNATIONAL,2015-04-01] -  Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice[ JOURNAL OF HEPATOLOGY,2015-07-01] -  Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice[ JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2015-08-19] -  Orphan nuclear receptor ERRα controls macrophage metabolic signaling and A20 expression to negatively regulate TLR-induced inflammation[ IMMUNITY,2015-07-21] -  Sulforaphane protects against acetaminophen-induced hepatotoxicity[ FOOD AND CHEMICAL TOXICOLOGY,2015-06-01] -  Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure[ DIABETOLOGIA,2015-04-01] -  Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression[ BIOCHEMICAL JOURNAL,2015-09-01] -  The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction[ ARCHIVES OF TOXICOLOGY,2015-11-02] -  cNAD(P)H:Quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive rats[ AMERICAN JOURNAL OF HYPERTENSION,2015-01-28] -  Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression[SCIENTIFIC REPORTS,2016-09-30] -  Analysis of the mouse gut microbiome using full-length 16S rRNA amplicon sequencing[SCIENTIFIC REPORTS,2016-06-14] -  The orphan nuclear receptor ERRγ regulates hepatic CB1 receptor-mediated fibroblast growth factor 21 gene expression[PLOS ONE,2016-06-25] -  Chemical constituents from Melicope pteleifolia leaves[ PHYTOCHEMISTRY,2016-10-01] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ONCOTARGET,2016-02-23] -  Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model[ NEUROBIOLOGY OF DISEASE,2016-05-02] -  Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection[NATURE MICROBIOLOGY,2016-10-16] -  Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity[ NATURE IMMUNOLOGY,2016-12-01] -  NQO1 inhibits proteasome-mediated degradation of HIF-1α[ NATURE COMMUNICATIONS,2016-12-14] -  NQO1-knockout mice are highly sensitive to Clostridium difficile toxin A-induced enteritis[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2016-08-28] -  Reply to Repurposing of metformin in liver injury: the JNK conundrum""[JOURNAL OF HEPATOLOGY,2016-03-01] -  High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives[ JOURNAL OF CONTROLLED RELEASE,2016-05-28] -  Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2016-10-01] -  STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-02-26] -  Glucose-6-phosphate dehydrogenase deficiency improves insulin resistance with reduced adipose tissue inflammation in obesity[ DIABETES,2016-09-01] -  Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis[ DIABETES,2016-10-01] -  O-GlcNAcylation of orphan nuclear receptor estrogen-related receptor γ promotes hepatic gluconeogenesis[ DIABETES,2016-10-01] -  Insulin-inducible SMILE inhibits hepatic gluconeogenesis[ DIABETES,2016-01-01] -  NQO1 deficiency leads enhanced autophagy in cisplatin-induced acute kidney injury through the AMPK/TSC2/mTOR signaling pathway[ ANTIOXIDANTS & REDOX SIGNALING,2016-05-20] -  Humulus japonicus prevents dopaminergic neuron death in 6-hydroxydopamine-induced models of Parkinson's disease[ JOURNAL OF MEDICINAL FOOD,2017-02-01] -  ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21[ JOURNAL OF ENDOCRINOLOGY,2017-04-01] -  Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis[ JOURNAL OF CELL BIOLOGY,2017-01-02] -  Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Kruppel-Like Factor 2 and Adhesion Molecules[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-02-10] -  Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells[ BMB REPORTS,2014-09-01] -  SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo[ DIABETES,2014-11-01] -  Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng[ JOURNAL OF NATURAL PRODUCTS,2014-07-25] -  Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling[ CIRCULATION RESEARCH,2014-08-15] -  Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease[ JOURNAL OF NEUROSCIENCE,2014-08-27]

Patent

-  4-하이드록시 타목시펜 유사체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 대사증후군 관련 질환의 예방 또는 치료용 조성물[2015-10-22] -  초두구 추출물, 이의 분획물 또는 이로부터 분리한 트리테르페노이드계 화합물들을 함유하는[2015-03-19] -  수련뿌리 추출물, 이의 분획물 또는 이로부터 분리된 폴리페놀계 화합물을 유효성분으로 함유하는 대사성 질환 예방 및 치료용 약학적 조성물[2014-11-11] -  세드렐라 휘실리스 추출물 또는 이의 분획물을 함유하는 대사성 질환 예방 또는 치료용 조성물[2016-06-23] -  PspA를 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학 조성물[2016-05-30] -  환삼덩굴 추출물을 포함하는 간질환 또는 동맥경화의 예방 또는 치료용 조성물[2015-04-24] -  환삼덩굴 추출물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 조성물[2016-12-13] -  딥터로카퍼스 투버큘라투스 추출물 또는 이의 분획물을 함유하는 대사성 질환 예방 및 치료용 약학적 조성물 [2014-10-29]