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Yeom Young IL(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Functional Genomics)
  • Contact Information042-860-4109
  • Major동물학과
  • DegreePh.D.
  • Highest Level of EducationUniversity of Texas, Austin
  • E-Mail

Field of Research

Cancer biology, Cancer genomics, Metabolic signaling

Research Results

-  Functional switching of transforming growth factor-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in tristetraprolin promoter. Gastroenterology. 138(5):1898-908 (2010). -  A Lactate-Induced Response to Hypoxia. Cell. 161(3):595-609 (2015). -  Regulation of hypoxia responses by flavin adenine dinucleotide-dependent modulation of HIF-1α protein stability. EMBO J. 36(8):1011-1028 (2017).

Treatise

-  Chotosan-mediated Non-viral Gene Delivery with Improved Serum Stability and Reduced Cytotoxicity[Biotechnology and Bioprocess Engineering,2014-11-03] -  SH3RF2 Functions as an Oncogene by Mediating PAK4 Protein Stability.[Carcinogenesis,2014-03-03] -  Donor-Derived Natural Killer Cells Infused after HLA-Haploidentical Hematopoietic Cell Transplantation: A Dose-Escalation Study[Biol Blood Marrow Transplant,2014-05-02] -  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer[Oncotarget,2014-04-07] -  Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis[Pathol. Res. Pract,2014-10-06] -  Knockdown of anterior gradient 2 expression extenuates tumor-associated phenotypes of SNU-478 ampulla of Vater cancer cells[BMC Cancer,2014-11-03] -  A Novel Pyruvate Kinase M2 Activator Compound that Suppresses Lung Cancer Cell Viability under Hypoxia[ MOLECULES AND CELLS,2015-04-01] -  A Lactate-Induced Response to Hypoxia[Cell,2015-04-23] -  Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma[BMC Genomics,2015-04-10] -  NDRG3-Mediated Lactate Signaling in Hypoxia[BMB Reports,2015-05-04] -  Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells[Experimental Cell Research,2015-08-01] -  Homeobox A9 directly targeted by miR-196b regulates aggressiveness through nuclear Factor-kappa B activity in non-small cell lung cancer cells[MOLECULAR CARCINOGENESIS,2016-12-01] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ONCOTARGET,2016-02-23] -  Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity[ CANCER RESEARCH,2016-03-01] -  AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth[ONCOTARGET,2016-07-26] -  Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-09-16] -  Regulation of hypoxia responses by flavin adenine dinucleotide-dependent modulation of HIF-1α protein stability[ EMBO JOURNAL,2017-04-13] -  High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury[PAIN,2016-04-01]

Patent

-  신규한 GPCR 단백질 및 이의 용도 (A NOVEL G PROTEIN COUPLED RECEPTOR AND A USE THEREOF)[2015-11-04] -  NDRG3 발현 또는 활성 촉진제를 유효성분으로 함유하는 허혈성 질환 예방 및 치료용 약학적 조성물[2016-09-29] -  암 치료용 약학 조성물 (Pharmaceutical composition for treating cancer)[2015-12-22] -  칼리크레인6의 발현 또는 활성 억제제를 유효성분으로 함유하는 항암제 민감성 증진용 약학적 조성물[2016-03-16] -  피루브산 키나아제 엠투(Pyruvate kinase type M2, PKM2)의발현또는활성억제제를유효성분으로함유하는 항암제민감성증진용약학적조성물[2016-03-17] -  NDRG3 단백질 특이적인 항체 및 이의 용도[2016-03-31] -  NDRG3 과발현 형질전환 동물모델 및 이의 용도[2017-01-06] -  SH3RF2 발현 또는 활성 억제제를 함유하는 암의 예방 또는 치료용 조성물 (Composition comprising expression or activity inhibitors of SH3RF2 for the prevention or treatment of cancer)[2014-08-19] -  TTP 프로모터 내 특정 단일 CpG 부위의 후생유전학적 지표를 이용한 암 발병/예후 진단 및 이의 조절을 통한 암 치료기술 (Method for diagnosis/prognosis of cancers using an epigenetic marker consisting of a specific single CpG site in TTP promoter and treatment of cancers by regulating its epigenetic status)[2014-04-22] -   암 진단을 위한 메틸화 바이오 마커 TESC 및 이의 용도 [2014-06-24] -  인간 TESC 단백질에 특이적으로 결합하는 단일클론항체 및 이의 용도[2014-06-24] -  LOC284422 유전자의 신규한 용도[2015-02-16] -  TMC5 유전자의 신규한 용도[2014-11-24]