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Kwon Ki Sun(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Functional Genomics)
  • Contact Information042-860-4143
  • Major미생물학과
  • DegreePh.D.
  • Highest Level of Education서울대학교
  • E-Mail

Field of Research

systems biology of aging, mechanisms in age-associated diseases and sarcopenia

Research Results

-  So Hee Dho, Benjamin E. Deverman, Carlo Lapid, Scott R. Manson, Lu Gan, Jacob J. Riehm, Rajeev Aurora, Ki-Sun Kwon*, & Steven J. Weintraub*: Control of Cellular Bcl-xL Levels by Deamidation-Regulated Degradation (2013) PLoS Biol. in press -  Lee KW, Maeng JS, Choi JY, Lee YR, Hwang CY, Park SS, Park HK, Chung BH, Lee SG, Kim YS, Jeon H, Eom SH, Kang C, Kim do H, Kwon KS*: Role of Junctin protein interactions in cellular dynamics of calsequestrin polymer upon calcium perturbation (2012) J Biol Chem. 287(3), 1679-87 -  Ryu YS, Lee Y, Lee KW, Hwang CY, Maeng JS, Kim JH, Seo YS, You KH, Song B, Kwon KS*: TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linkedinhibitor of apoptosis (XIAP) (2011) J Biol Chem. 286(29), 25729-38

Treatise

-  Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging[Aging (Albany NY),2014-06-12] -  MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species[Sci Signal.,2014-06-03] -  Peroxiredoxin 3 has a Crucial Role in the Contractile Function of Skeletal Muscle via Regulating Mitochondrial Homeostasis.[Free Radic Biol Med.,2014-09-12] -  STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells[EXPERIMENTAL CELL RESEARCH,2017-02-01] -  Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration[ AGING-US,2016-09-21] -  Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva[PLOS ONE,2016-07-08] -  GPR171 expression enhances proliferation and metastasis of lung cancer cells[ONCOTARGET,2016-01-09] -  NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin[ONCOTARGET,2015-10-15] -  Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast[ELIFE,2015-09-02] -  miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4[ GENES & DEVELOPMENT,2015-08-01] -  Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/β-catenin signaling[ JOURNAL OF LIPID RESEARCH,2015-02-01] -  Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity[ BRAIN RESEARCH,2014-10-18] -  The anoctamin family channel subdued mediates thermal nociception in Drosophila[ JOURNAL OF BIOLOGICAL CHEMISTRY,2015-01-23] -  microRNA for determining the age-related myogenic capabilities of skeletal muscle[ BMB REPORTS,2015-11-01]

Patent

-  신규한 암 치료 표적인 MAP7D2 단백질의 발현 또는 활성 억제제를 포함하는 암 치료 또는 암 전이 억제용 약학적 조성물[2014-03-14] -  MyoD 단백질을 포함하는 근육 분화 유도용 조성물[2017-01-23] -  NOX5의 발현 또는 활성을 억제하는 제제를 포함하는 암 치료용 조성물[2016-09-28] -  플록사신 계열의 화합물을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물[2016-09-13] -  부틸 피리디늄 또는 이의 유도체를 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물 [2016-10-10] -  베타카리오필렌알코올 또는 이의 약학적으로 허용 가능한 염을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물[2017-08-07] -  아세카이니드 또는 이의 유도체를 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물[2017-04-14] -  근육 노화 탐지 마커 및 이의 용도[2015-12-03] -  테트라미졸을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물[2015-12-01] -  클로로크레졸을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물[2015-07-02] -  바이칼린-아연착염을 포함하는 비만억제용 [2017-07-07]