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Lee Jae Ran(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Bio-Molecular Science)
  • Contact Information042-879-8437
  • Major생화학
  • DegreePh.D.
  • Highest Level of Education서울대학교
  • E-Mail

Field of Research

Development of brain/neuronal cells and regulation of neuronal synapse formation

Research Results

-  Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT (2012) J. Cell Sci. 125(19):4518-4531 -  Excess of de novo deleterious mutation in genes associated with glutamatergic systems in non-syndromic intellectual disability (2011) Am. J. Hum. Genetics. 88(3):306-316 -  Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn (2009) EMBO J. 28:3564-3578

Treatise

-  Protein tyrosine phosphatase PTPRT as a regulator of synaptic formation and neuronal development[BMB REPORTS,2015-03-02] -  De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy and cerebellar atrophy[ HUMAN MUTATION,2015-02-23] -  STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance [ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-02-26] -  Protective effects of P2X7 receptor deletion on aging-related memory alterations[GENES & GENOMICS,2016-03-21]

Patent

-  PTPRT 및 신탁신-결합 단백질1을 이용한 시냅스 형성 조절제의 스크리닝 방법[2015-04-16]