본문 바로가기 대메뉴 바로가기
Hong Young Soo(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Bio-Molecular Science)
  • Contact Information043-240-6144
  • Major분자생물학
  • DegreePh.D.
  • Highest Level of Education부산대학교
  • E-Mail

Field of Research

Biosynthesis of microbial secondary metabolites

Research Results

-  Sun-Young Kang et al. Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain. Microbial Cell Factories 11(1), 153 (2012) -  Cheng-Zhu Wu et al. Enzymatic Glycosylation of Nonbenzoquinone Geldanamycin Analogs via Bacillus UDP-Glycosyltransferase Appl. Environ. Microbiol. 78(21):7680-7686 (2012) -  Young-Soo Hong et al. Inactivation of the carbamoyltransferase gene refines the post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin. J. Am. Chem. Soc. 126(36) 11142-11143 (2004)

Treatise

-  Construction of artificial biosynthetic pathways for resveratrol glucoside derivatives[J. Microbiol. Biotechnol.,2014-05-28] -  Anticancer effects of the Hsp90 inhibitor 17-demethoxy-reblastatin in human breast cancer MDA-MB-231 cells[J. Microbiol. Biotechnol.,2014-07-28] -  Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR[ONCOLOGY REPORTS,2014-04-28] -  Biosynthesis of methylated resveratrol analogs through the construction of an artificial biosynthetic pathway in E. coli[BMC Biotechnology,2014-07-17] -  Anti-tumor activity of WK88-1 a novel geldanamycin derivative in gefitinib-resistant NSCLCs with Met amplification[Cancer science,2014-09-25] -  Mechanism of the pH-Induced Conformational Change in the Sensor Domain of the DraK Histidine Kinase via the E83 E105 and E107 Residues.[PLoS ONE,2014-09-09] -  Inhibition of indoleamine 23-dioxygenase by thielavin derivatives from a soil fungus Coniochaeta sp. 10F058[Journal of Antibiotics,2014-07-15] -  Artificial de novo biosynthesis of hydroxystyrene derivatives in a tyrosine overproducing Escherichia coli strain[Microbial Cell Factories,2015-06-10] -  Production of phenylacetyl?homoserine lactone analogs by artificial biosynthetic pathway in Escherichia coli[ MICROBIAL CELL FACTORIES,2015-11-25] -  Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase[Archives of Pharmacal Research,2015-12-05] -  Biosynthesis of Novel Glucosides Geldanamycin Analogs by Enzymatic Synthesis[Journal of Microbiology and Biotechnology,2016-01-28] -  Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library[ JOURNAL OF ANTIBIOTICS,2016-12-21] -  De novo biosynthesis of pterostilbene in an Escherichia coli strain using a new resveratrol O-methyltransferase from Arabidopsis[ MICROBIAL CELL FACTORIES,2017-02-15] -  Metabolic Engineering for Resveratrol Derivative Biosynthesis in Escherichia coli[ MOLECULES AND CELLS,2015-04-10] -  A new dimeric neolignan from Magnolia grandiflora L. seeds [ ARCHIVES OF PHARMACAL RESEARCH,2015-06-10] -  Ulleungamides A and B, Modified α,β-Dehydropipecolic Acid Containing Cyclic Depsipeptides from Streptomyces sp. KCB13F003[ ORGANIC LETTERS,2015-08-11] -  Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005.[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-10-10] -  Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field[ PHYTOCHEMISTRY,2016-01-01] -  New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006[ MARINE DRUGS,2016-04-02] -  Characterization of Xylobiose- and Xylopentaose-Producing β-1,4-Endoxylanase SCO5931 from Streptomyces coelicolor A3(2) [ APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2016-05-05] -  Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells[ JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2016-09-22] -  Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013[ JOURNAL OF NATURAL PRODUCTS,2016-10-11] -  Production of Bacterial Quorum Sensing Antagonists, Caffeoyl- and[Journal of Microbiology and Biotechnology,2017-12-28] -  Sam5, a Coumarate 3-Hydroxylase from Saccharothrix espanaensis: New Insight into the Piceatannol Production as a Resveratrol 3'-Hydroxylase.[ CHEMISTRYSELECT,2017-10-02]

Patent

-  신규한 젤다나마이신 유도체 이의 약학적으로 허용가능한 염 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및 치료제[2014-11-28] -  4-하이드록시스티렌 및 이의 유사체의 생산능을 가지는 형질전환체 및 이의 생산 방법[2016-12-07] -  페닐아세틸 호모세린 락톤 유도체의 생산 방법[2017-04-06] -  레스베라트롤 글루코사이드 유도체 생합성용 컨스트럭트 및 이를 이용한 생산방법 [2016-02-01] -  메틸전이효소 암호화 폴리뉴클레오티드 및 이를 이용한 메틸화 스틸벤 화합물의 생산방법 [2016-01-07] -  타이로신 고생산 균주에서의 인공대사 경로를 통한 4-쿠마린산, 카페인산 및 페룰린산의 생산 방법[2015-06-04] -  용해도가 증가된 비―퀴논 젤다나마이신 당전이 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이의 열충격 단백질(Hsp90) 에이티피아제(ATPase) 활성 저해용 약학적조성물[2014-10-23]