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Kim KyoungShim(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Functional Genomics)
  • Contact Information042-860-4634
  • Major신경과학
  • DegreePh.D.
  • Highest Level of Education이화여자대학교
  • E-Mail

Field of Research

Behavioral, genetic and functional studies for neurological disorders (neural disease models, behavioural genetics)

Research Results

-  Kim KS, Lee KW, Lee KW, Im JY, Yoo JY, Kim SW, Lee JK, Nestler EJ, Han PL. Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action. Proc. Natl. Acad. Sci. USA. 2006 Mar 7;103(10):3908-13. -  Kim KS, Lee KW, Baek IS, Lim CM, Krishnan V, Lee JK, Eric J. Nestler, Han PL. Adenylyl Cyclase-5 Activity in the Nucleus Accumbens Gates Anxiety-Related Behavior. J. Neurochem. 2008 Oct;107(1):105-15. -  Kim KS, Kim H, Baek IS, Lee KW, Han PL. Mice lacking adenylyl cyclase type 5 (AC5) show increased ethanol consumption and reduced ethanol sensitivity. Psychopharmacology (Berl). 2011 May;215(2):391-8

Treatise

-  Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson’s disease[ JOURNAL OF NEUROSCIENCE,2014-08-27] -  Adenylyl cyclase-5 in the dorsal striatum function as a molecular switch for the generation of behavioral preferences for cue-directed food choices[ MOLECULAR BRAIN,2014-11-07] -  Enhanced production of adenosine triphosphate by pharmacological activation of adenosine monophosphate-activated protein kinase ameliorates acetaminophen-induced liver injury[Molecules and Cells,2015-10-02] -  Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice[ JOURNAL OF HEPATOLOGY,2015-02-12] -  NAD(P)H:Quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive rats[ AMERICAN JOURNAL OF HYPERTENSION,2015-02-28] -  Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease[ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015-07-14] -  Sulforaphane protects against acetaminophen-induced hepatotoxicity[ FOOD AND CHEMICAL TOXICOLOGY,2015-03-25] -  The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction[ FOOD AND CHEMICAL TOXICOLOGY,2014-09-17] -   Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2016-08-12] -  Humulus japonicus inhibits the progression of Alzheimer’s disease in a APP/PS1 transgenic mouse model[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2017-01-01] -  Humulus japonicus prevents dopaminergic neuron death in 6-hydroxydopamine-induced models of Parkinson’s disease[Journal of Medicinal Food,2017-01-01] -  Daphnane diterpenes from Daphne genkwa activate Nurr1 and have a neuroprotective effect in an animal model of Parkinson’s disease[ JOURNAL OF NATURAL PRODUCTS,2016-03-26] -  Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson’s disease mouse model[ NEUROBIOLOGY OF DISEASE,2016-01-01] -  Palmitoyl serotonin inhibits L-dopa-induced abnormal involuntary movements in the mouse Parkinson model[Experimental Neurobiology,2016-01-01] -  STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance[Experimental and Molecular Medicine,2016-01-01]

Patent

-  병아리꽃나무 추출물을 포함하는 조성물[2015-08-25] -  PspA를 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학 조성물[2016-05-30] -  환삼덩굴 추출물을 포함하는 간질환 또는 동맥경화의 예방 또는 치료용 조성물[2015-04-24] -  환삼덩굴 추출물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 조성물[2016-12-06] -  팥꽃나무 추출물 또는 이로부터 분리된 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 약학적 조성물[2015-05-19]