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Seon-Jin Lee(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Functional Genomics)
  • Contact Information042-860-4185
  • Major분자세포생화학
  • DegreePh.D.
  • Highest Level of Education강원대학교
  • E-Mail

Field of Research

Autophagy, tumor biomarker, tumor microenvironment

Research Results

-  Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C, Ryter SW, Kim HP, Rabinobitch M, and Choi AM (2011) Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 183(5): 649-658. -  Lee SJ, Kim HP, Jin Y, Choi AM, and Ryter SW (2011) Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy -  Lee SJ, Zhang M, An CH, Xu JF, Joshi B, Nabi IR, Choi AM and Jin Y (2011) Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic Biol Med. 50(10):1252-1262.

Treatise

-  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer[Oncotarget,2014-03-19] -  Trichostatin A sensitizes hepatocellular carcinoma cells to enhanced NK cell-mediated killing by regulating immune-related genes[ CANCER GENOMICS & PROTEOMICS,2017-07-20] -  Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer[ ONCOTARGET,2016-11-15] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer[Cell Death and Disease,2017-03-16] -  Tescalcin expression contributes to invasive and metastatic activity in colorectal cancer[ TUMOR BIOLOGY,2016-08-02] -  Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases[ ACTA BIOMATERIALIA,2016-09-15] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ ONCOTARGET,2016-01-27] -  Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer[ ONCOTARGET,2015-12-10] -  CCN1 suppresses pulmonary vascular smooth muscle contraction in response to hypoxia[ PULMONARY CIRCULATION,2015-10-07] -  Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression[ JOURNAL OF HEPATOLOGY,2015-08-17] -  Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death[ ONCOTARGET,2015-09-10] -  Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody[ BIOMATERIALS,2015-02-17] -  Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer[Cancer Biomarkers,2017-10-26] -  Ephrin B1 promotes cancer cell migration and invasion through the interaction with RhoGDI1[Cancer Biomarkers,2017-10-26] -  Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor-1 and suppresses cancer cell migration and invasion[Cancer Biomarkers,2017-10-25] -  Vitexin confers HSF-1 mediated autophagic cell death by activating JNK and ApoL1 in colorectal carcinoma cells[ ONCOTARGET,2017-08-10]

Patent

-  심혈관 질환 마커 파랄레민 및 이를 이용한 심혈관 질환 진단 방법[2016-01-21] -  칼리크레인6의 발현 또는 활성 억제제를 유효성분으로 함유하는 항암제 민감성 증진용 약학적 조성물[2016-03-16] -  심혈관 질환 마커 파랄레민 및 이를 이용한 심혈관 질환 진단 방법[2015-04-22]