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Bonsu Ku(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Proteome Structural biology)
  • Contact Information042-860-4246
  • Major분자생명과학부
  • DegreePh.D.
  • Highest Level of Education포항공과대학교
  • E-Mail

Field of Research

Structural Biology

Research Results

-  Yun H-Y, Kim MW, Lee HS, Kim W, Shin JH, Kim H, Shin H-C, Park H, Oh B-H, Kim WK, Bae K-H, Lee SC, Lee E-W#, Ku B#, Kim SJ# / Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus / PLoS Biology / 2019-07 -  Lee HS, Lee S, Kim J-S, Lee H-R, Shin H-C, Lee M-S, Jin KS, Kim C-H, Ku B#, Ryu C-M#, Kim SJ# / Structural and physiological exploration of Salmonella Typhi YfdX uncovers its dual function in bacterial antibiotic stress and virulence / Front Microbiol / 2019-01 -  Park S-Y*, Park J-E*, Kim T-S*, Kim JH*, Kwak M-J*, Ku B*, et al. / Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis / Nat. Struct. Mol. Biol. / 2014-08

Treatise

-  Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis[ NATURE STRUCTURAL & MOLECULAR BIOLOGY,2014-08-01] -  Structural analysis of the polo-box domain of human Polo-like kinase 2[ PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2015-07-01] -  Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain[CELL DEATH & DISEASE,2015-07-02] -  Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-01] -  Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM2, a subunit of ESCRT-0[PLOS ONE,2016-02-11] -  Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming[ CANCER CELL,2016-08-08] -  High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-09-23] -  Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptococcus pyogenes[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-09-23] -  Discovery of novel striatal-enriched protein tyrosine phosphatase inhibitors through structure-based virtual screening[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-11-07] -  Identification of a highly conserved hypothetical protein TON_0340 as a probable manganese-dependent phosphatase[PLOS ONE,2016-12-01] -  The discovery of novel protein tyrosine phosphatase ε inhibitors using a high-throughput screening approach[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2017-01-09] -  Two-track virtual screening approach to identify both competitive and allosteric inhibitors of human small C-terminal domain phosphatase 1[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2017-06-26] -  Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a novel and dual malate dehydrogenase (MDH) 1/2 inhibitor targeting cancer metabolism[ JOURNAL OF MEDICINAL CHEMISTRY,2017-10-26] -  Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase[ ARCHIVES OF VIROLOGY,2017-11-01] -  Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28[PLOS ONE,2017-11-09] -  Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1[PLOS ONE,2018-05-23] -  Crystallization and preliminary diffraction analysis of DUSP28 through identification of a pseudo-thrombin cleavage site [Biodesign,2017-12-31] -  Crystallization and preliminary diffraction analysis of human TEAD1, a transcriptional enhancer factor that controls the Hippo signaling pathway[Biodesign,2018-09-30] -  Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activity[BIOORGANIC & MEDICINAL CHEMISTRY,2018-10-01] -  Purification, crystallization, and preliminary X-ray diffraction data analysis for PB1 dimer of P62/SQSTM1[Biodesign,2018-12-30] -  Crystal structure of the YAP-binding domain of human TEAD1[BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2019-01-20] -  Structural and physiological exploration of Salmonella Typhi YfdX uncovers its dual function in bacterial antibiotic stress and virulence[FRONTIERS IN MICROBIOLOGY,2019-01-14]

Patent

-  Akt에 의해 활성화되어 암세포를 선별 사멸시키는 신규 BIM BH3 돌연변이 펩타이드[2015-08-03]