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CHO, HYUN-SOO(Professor)

INFO

  • AffiliationKRIBB School
  • Majors Bioscience
    (Functional Genomics)
  • Contact Information042-879-8152
  • Major분자세포생물학
  • DegreePh.D.
  • Highest Level of EducationUniversity of Tokyo
  • E-Mail

Field of Research

Development of a new cancer therapy targeting histone methyltransferases and demethylases.

Research Results

-  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models. Hepatology. 2017 Nov;66(5):1662-1674 -  Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression. Cancer Res. 2012 Jul 1;72(13):3217-3227 -  Enhanced HSP70 lysine 561 methylation promotes proliferation of cancer cells through activation of aurora kinase B. Nat Commun. 2012;3:1072.

Treatise

-  Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7?TIPRL in human hepatocellular carcinoma cells[Oncology Reports,2014-07-23] -  WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck[Molecular Cancer Research,2015-03-01] -  Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells[Molecular Carcinogenesis,2015-03-01] -  IFT46 plays an essential role in cilia development[DEVELOPMENTAL BIOLOGY,2015-04-15] -  SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells[Oncotarget,2015-12-22] -  Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells[Oncotarget,2015-09-15] -  Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis[Oncotarget,2016-11-29] -  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models[HEPATOLOGY,2017-06-22] -  Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo[SCIENTIFIC REPORTS,2017-09-05] -  Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in hepatocellular carcinoma[Oncotarget,2017-11-03] -  Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC[Oncotarget,2017-12-14] -  In vitro and in vivo imaging and tracking of intestinal organoids from human induced pluripotent stem cells[FASEB JOURNAL,2018-01-06] -  Bioinformatic analysis of regulation of natural antisense transcripts by transposable elements in human mRNA[GENOMICS,2018-01-20] -  EHMT2 is a metastasis regulator in breast cancer.[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018-01-11]