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김연구 교수

Yeon-Gu Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명공학
    (생물공정공학)
  • 연락처042-860-4196
  • 출신전공생명과학과
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일

연구분야

무혈청 부유형 동물세포배양 기반 바이오의약품 생산공정개발

Process development for biopharmaceutical protein production in serum-free suspended mammalian cells

대표연구실적

-  김연구(교신) 외 2인 / Effect of Bcl-xL overexpression on sialylation of Fc-fusion protein in recombinant Chinese hamster ovary cell cultures / Biotechnol Prog / 2015.07.01 -  김연구(교신) 외 2인 / Understanding of altered N-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting / Biotechnol Bioeng / 2015.08.01 -  김연구(교신) 외 5인 / Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells / Process Biochem. / 2017.04.01

논문(최근 5년)

-  Label-free measurement of cell viability via counting cells attached on affinity substrates[ BIOTECHNOLOGY AND BIOPROCESS ENGINEERING,2014-03-01] -  Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2014-11-01] -  Monitoring change in refractive index of cytosol of animal cells on affinity surface under osmotic stimulus for label-free measurement of viability[ BIOSENSORS & BIOELECTRONICS,2015-02-15] -  Radial scale-down of packed bed chromatography in a thin cylindrical tube for preparative media[ PROCESS BIOCHEMISTRY,2015-05-01] -  Effect of Bcl-xL overexpression on sialylation of Fc-fusion protein in recombinant Chinese hamster ovary cell cultures[ BIOTECHNOLOGY PROGRESS,2015-07-01] -  Understanding of altered N-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting[ BIOTECHNOLOGY AND BIOENGINEERING,2015-08-01] -  A single-plasmid vector for transgene amplification using short hairpin RNA targeting the 3'-UTR of amplifiable dhfr[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2015-12-01] -  A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells[ BIOTECHNOLOGY JOURNAL,2016-05-01] -  Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells[ PROCESS BIOCHEMISTRY,2017-04-01] -  Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile[ BIOTECHNOLOGY AND BIOENGINEERING,2017-08-01] -  Improvement of Human Erythropoietin Expression by IRES- mediated Multicistronic Vector in Chinese Hamster Ovary Cells[KSBB Journal,2015-04-01] -  High Performance Cell Line Development Platform for Therapeutic Protein Production in Recombinant Chinese Hamster Ovary Cells[KSBB Journal,2014-04-01]

특허(최근 5년)

-  재조합 단백질 발현 증진을 위한 유전자 절편을 포함하는 벡터 및 이의 용도[2016-02-24] -  목적 유전자 발현 증가용 재조합 벡터 및 이의 이용[2016-06-03] -  항원성 단백질 고정화를 통한 돈단독 백신 제조방법[2015-07-03] -  VECTOR COMPRISING GENE FRAGMENT FOR ENHANCEMENT OF RECOMBINANT PROTEIN EXPRESSION AND USE THEREOF[2017-08-03] -  VECTOR COMPRISING GENE FRAGMENT FOR ENHANCEMENT OF RECOMBINANT PROTEIN EXPRESSION AND USE THEREOF[2017-04-26]

연구과제 수행 실적

신진연구자지원사업 예비히든챔피언육성사업 지역주력산업육성사업