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김명희 교수

Myung Hee Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명공학
    (시스템생명공학)
  • 연락처042-879-8219
  • 출신전공식품미생물
  • 학위박사
  • 최종출신대학충남대학교
  • 이메일

연구분야

구조생물학 및 생화학 기반 감염 질환의 병인 및 면역 신호 전달 기전 연구

Structural biology and biochemistry-based infection and immunity signaling

대표연구실적

-  1. Hwang J, Suh HW, Jeon YH, Hwang E, Nguyen LT, Yeom J, Lee SG, Lee C, Kim KJ, Kang BS, Jeong JO, Oh TK, Choi I, Lee JO, Kim MH. 1. The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. Nature Communications. in press, 2013 -  Hwang J, Kim BS, Jang SY, Lim JG, You DJ, Jung HS, Oh TK, Lee JO, Choi SH, Kim MH. Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proc Natl Acad Sci. 2013 -  Lee HR, Choi WC, Lee S, Hwang J, Hwang E, Guchhait K, Haas J, Toth Z, Jeon YH, Oh TK, Kim MH, Jung JU. Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. Nature Structural and Molecular Biology. 2011

논문(최근 5년)

-  BaeR protein from Salmonella enterica serovar Paratyphi A induces inflammatory response in murine and human cell lines.[Microbes Infect,2013-11-01] -  Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR.[Proc Natl Acad Sci,2013-07-05] -  The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein[Nature Communications,2013-12-13] -  Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells[Journal of Microbiology and Biotechnology,2013-12-01] -  Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation[ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014-10-01] -  Profiling and characterization of influenza virus N1 strains potentially resistant to multiple neuraminidase inhibitors[ JOURNAL OF VIROLOGY,2015-01-01] -  Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome[Nature Communications,2015-02-06] -  The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus[PLoS Pathogens,2015-09-25] -  Crystal structure of fully oxidized human thioredoxin[Biochemical and Biophysical Research Communications,2015-11-13] -  Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene[ JOURNAL OF VIROLOGY,2015-10-21] -  Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death[Infection and Immunity,2015-10-26] -  Shiga Toxins Trigger the Secretion of Lysyl-tRNA Synthetase to Enhance Proinflammatory Responses[Journal of Microbiology and Biotechnology,2016-02-01] -  Molecular Insights into Toluene Sensing in the TodS/TodT Signal Transduction System[JOURNAL OF BIOLOGICAL CHEMISTRY,2016-04-15] -  Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2[ CANCER RESEARCH,2016-06-01] -  BaeR protein acts as an activator of nuclear factor-kappa B and Janus kinase 2 to induce inflammation in murine cell lines[ CANADIAN JOURNAL OF MICROBIOLOGY,2016-09-01] -  Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity[Nature Immunology,2016-11-01] -  Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection[ MICROBES AND INFECTION,2016-09-13]

특허(최근 5년)

-  Hausp-vIRF4의 복합체 입체구조와 HAUSP deubiquitinase에 대한 펩타이드 저해제[2013-09-26] -  TRX-TXNIP 복합체 변형 단백질의 결정화 방법 및 그의 입체 구조[2013-07-16] -  TRX-TXNIP 복합체 변형 단백질의 결정화 방법 및 그의 입체 구조[2013-07-23] -  ManNAc-6P과 NanR 단백질 결합체의 결정화 방법 및 그의 입체 구조[2013-06-24] -  해양 미생물 플라보박테리움 동해아나 독도넨시스 DSW-6 유래의 NQ 로돕신 유전자[2013-06-19] -  병원성 미생물의 의사소통 저해제 및 이를 이용한 항균 조성물[2013-05-21] -  NanR 단백질과 ManNAc-6P 결합체의 입체 구조와 이의 활용[2016-09-23] -  해양 미생물 플라보박테리움 동해아나 독도넨시스 DSW-6 유래의 NQ 로돕신 유전자[2015-06-05] -  대장암에 특이적인 항암 활성을 갖는 신규 펩타이드, 이를 포함하는 NDRG2 결정체 및 이의 용도[2014-07-14] -  TRX-TXNIP 복합체 변형 단백질의 결정화 방법 및 그의 입체구조[2016-07-13]