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오두병 교수

Oh, Doo-Byoung

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명공학
    (시스템생명공학)
  • 연락처042-860-4457
  • 출신전공생물과학
  • 학위박사
  • 최종출신대학한국과학기술원
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개인홈페이지

연구분야

단백질/항체공학, 당생물학

Protein/Antibody Engineering, Glycobiology

대표연구실적

-  Kim YH, Kang JY, Gil JY, Kim SY, Shin KK, Kang HA, Kim JY, Kwon O, Oh DB. “Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes” Appl Microbiol Biotechnol, 101: 2979-2989 (2017) -  Mun JY, Shin KK, Kwon O, Lim YT, Oh DB. “Minicircle microporation-based non-viral gene delivery improved the targeting of mesenchymal stem cells to an injury site” Biomaterials 101: 310-320 (2016) -  Mun JY, Lee KJ, Seo H, Sung MS, Cho YS, Lee SG, Kwon O, Oh DB. “Efficient Adhesion-based Plasma Membrane Isolation for Cell Surface N-glycan Analysis” Anal Chem 85: 7462-7470 (2013)

논문(최근 5년)

-  N-glycan analysis of human α1-antitrypsin produced in Chinese hamster ovary cells[Glycoconj J,2013-07-01] -  Development of a genome-wide random mutagenesis system using proofreading-deficient DNA polymerase δ in the methylotrophic yeast Hansenula polymorpha[J Microbiol Biotechnol,2013-03-01] -  Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation[BMB Rep,2013-03-01] -  N-glycan maturation is crucial for cytokinin-mediated development and cellulose synthesis in Oryza sativa[Plant J,2013-03-01] -  Transcriptome analysis of xylose metabolism in the thermotolerant methylotrophic yeast Hansenula polymorpha[Bioprocess Biosyst Eng,2013-03-01] -  Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein[Biochem Biophys Res Commun,2013-07-19] -  Efficient Adhesion-based Plasma Membrane Isolation for Cell Surface N-glycan Analysis[Anal Chem,2013-07-08] -  Functional and molecular characterization of novel Hansenula polymorpha genes HpPMT5 and HpPMT6 encoding protein O-mannosyltransferases[Fungal Genet Biol,2013-09-01] -  Intracellular reprogramming of expression glycosylation and function of a plant-derived antiviral therapeutic monoclonal antibody[PLoS One,2013-08-15] -  Use of human serum albumin fusion tags for recombinant protein secretory expression in the methylotrophic yeast Hansenula polymorpha[KOREAN JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2013-03-01] -  Glycomodification and characterization of anti-colorectal cancer immunotherapeutic monoclonal antibodies in transgenic tobacco[Plant Cell Tiss Org,2013-04-01] -  Novel cysteine-centered sulfur metabolic pathway in the thermotolerant methylotrophic yeast Hansenula polymorpha[PLOS ONE,2014-06-01] -  Characterization of modular bifunctional processive endoglucanase Cel5 from Hahella chejuensis KCTC 2396[APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2014-05-01] -  Characterization of putative glycosylphosphatidylinositol-anchoring motifs for surface display in the methylotrophic yeast Hansenula polymorpha[Biotechnology Letter,2014-10-01] -  Molecular Characterization of Acidic Peptide:N-glycanase from the Dimorphic Yeast Yarrowia lipolytica[ JOURNAL OF BIOCHEMISTRY,2015-01-01] -  The CpxRA two-component system is involved in the maintenance of the integrity of the cell envelope in the rumen bacterium Mannheimia succiniciproducens[ CURRENT MICROBIOLOGY,2015-01-01] -  Multifunctional cellulolytic auxiliary activity protein HcAA10-2 from Hahella chejuensis enhances enzymatic hydrolysis of crystalline cellulose[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2015-04-01] -  Effect of the developmental stage and tissue position on the expression and glycosylation of recombinant glycoprotein GA733-FcK in transgenic plants[FRONTIERS IN PLANT SCIENCE,2015-01-13] -  Nanomaterials for enhanced immunity as an innovative paradigm in nanomedicine[NANOMEDICINE,2015-04-01] -  Increased mannosylphosphorylation of N-glycans by heterologous expression of YlMPO1 in glyco-engineered Saccharomyces cerevisiae for mannose-6-phosphate modification[ JOURNAL OF BIOTECHNOLOGY,2015-07-01] -  Glycan structure and serum half-life of recombinant CTLA4Ig, an immunosuppressive agent, expressed in suspension-cultured rice cells with coexpression of human β1,4-galactosyltransferase and human CTLA4Ig[ GLYCOCONJUGATE JOURNAL,2015-05-01] -  Enhanced Bacterial α(2,6)-Sialyltransferase Reaction through an Inhibition of Its Inherent Sialidase Activity by Dephosphorylation of Cytidine-5'-Monophosphate[PLOS ONE,2015-07-01] -  Glyco-engineering strategies for development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage[BMB REPORTS,2015-05-02] -  Hansenula polymorpha Hac1p Is Critical to Protein N-Glycosylation Activity Modulation, as Revealed by Functional and Transcriptomic Analyses[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2015-10-01] -  N-glycan containing a core α1,3-fucose residue is required for basipetal auxin transport and gravitropic response in rice[ NEW PHYTOLOGIST,2016-10-01] -  Effects of a Hot-Water Extract of Allium hookeri Roots on Bone Formation in Human Osteoblast-Like MG-63 Cells In Vitro and in Rats In Vivo[ PLANTA MEDICA,2016-11-01] -  Data for analysis of mannose-6-phosphate glycans labeled with fluorescent tags[Data in Brief,2016-04-01] -  Comparison of fluorescent tags for analysis of mannose-6-phosphate glycans[ ANALYTICAL BIOCHEMISTRY,2016-02-11] -  Minicircle microporation-based non-viral gene delivery improved the targeting of mesenchymal stem cells to an injury site[ BIOMATERIALS,2016-09-01] -  Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity[ BIOMATERIALS,2017-06-01] -  Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2017-04-01]

특허(최근 5년)

-  외래 유전자 강제 발현 벡터[2014-01-02] -  단백질 번역을 촉진하는 인공 비번역 선도서열[2015-10-23] -  열 스트레스 반응을 조절할 수 있는 한세눌라 폴리모르파 유래 신규 열 충격 인자 및 이의 용도[2017-02-10] -  YlMPO1 과발현을 이용한 만노스인산화 반응[2017-06-20] -  개선된 효율을 갖는 시알산전달효소를 이용한 당단백질의 당사슬에 시알산을 부가하는 방법[2017-07-03] -  사카로마이세스 세레비지애 효모의 만노스인산화 활성에 핵심적인 유전자 MNN14 및 그 결손 변이주를 활용한 재조합 당단백질 생산 방법[2017-09-22] -  A novel gene from Hansenula polymorpha capable of controlling unfolded protein response[2017-03-02]

연구과제 수행 실적

CHO 세포 기반의 재조합 HSV 당단백질 항원 발현 시스템 확립 글리칸 구조 분석 및 리모델링을 이용한 바이오의약품 최적화 기술 개발 유산균 배양물 내의 항바이러스 성분 분리 및 구조 규명 인공당사슬 생합성 경로를 이용한 효소 치료제 생산용 맞춤형 효모 개발