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오두병 교수

Oh, Doo-Byoung

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명공학
    (시스템생명공학)
  • 연락처042-860-4457
  • 출신전공생물과학
  • 학위박사
  • 최종출신대학한국과학기술원
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개인홈페이지

연구분야

단백질공학, 당생물학

Protein Engineering, Glycobiology

대표연구실적

-  Kim YH, Kang JY, Gil JY, Kim SY, Shin KK, Kang HA, Kim JY, Kwon O, Oh DB. “Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes” Appl Microbiol Biotechnol, 101: 2979-2989 (2017) -  Mun JY, Shin KK, Kwon O, Lim YT, Oh DB. “Minicircle microporation-based non-viral gene delivery improved the targeting of mesenchymal stem cells to an injury site” Biomaterials 101: 310-320 (2016) -  Mun JY, Lee KJ, Seo H, Sung MS, Cho YS, Lee SG, Kwon O, Oh DB. “Efficient Adhesion-based Plasma Membrane Isolation for Cell Surface N-glycan Analysis” Anal Chem 85: 7462-7470 (2013)

논문(최근 5년)

-  Characterization of alcohol dehydrogenase 3 of the thermotolerant methylotrophic yeast Hansenula polymorpha[Appl Microbiol Biotechnol,2012-11-01] -  Ylpex5 mutation partially suppresses the defective hyphal growth of a Yarrowia lipolytica ceramide synthase mutant Yllac1 by recovering lipid raft polarization and vacuole morphogenesis[Fungal Genet Biol,2013-01-01] -  N-glycan analysis of human α1-antitrypsin produced in Chinese hamster ovary cells[Glycoconj J,2013-07-01] -  Development of a genome-wide random mutagenesis system using proofreading-deficient DNA polymerase δ in the methylotrophic yeast Hansenula polymorpha[J Microbiol Biotechnol,2013-03-01] -  Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation[BMB Rep,2013-03-01] -  N-glycan maturation is crucial for cytokinin-mediated development and cellulose synthesis in Oryza sativa[Plant J,2013-03-01] -  Transcriptome analysis of xylose metabolism in the thermotolerant methylotrophic yeast Hansenula polymorpha[Bioprocess Biosyst Eng,2013-03-01] -  Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein[Biochem Biophys Res Commun,2013-07-19] -  Efficient Adhesion-based Plasma Membrane Isolation for Cell Surface N-glycan Analysis[Anal Chem,2013-08-06] -  Functional and molecular characterization of novel Hansenula polymorpha genes HpPMT5 and HpPMT6 encoding protein O-mannosyltransferases[Fungal Genet Biol,2013-09-01] -  Intracellular reprogramming of expression glycosylation and function of a plant-derived antiviral therapeutic monoclonal antibody[PLoS One,2013-08-15] -  Use of human serum albumin fusion tags for recombinant protein secretory expression in the methylotrophic yeast Hansenula polymorpha[KOREAN JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2013-03-01] -  Glycomodification and characterization of anti-colorectal cancer immunotherapeutic monoclonal antibodies in transgenic tobacco[Plant Cell Tiss Org,2013-04-01] -  Novel cysteine-centered sulfur metabolic pathway in the thermotolerant methylotrophic yeast Hansenula polymorpha[PLOS ONE,2014-06-01] -  Characterization of modular bifunctional processive endoglucanase Cel5 from Hahella chejuensis KCTC 2396[APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2014-05-01] -  Characterization of putative glycosylphosphatidylinositol-anchoring motifs for surface display in the methylotrophic yeast Hansenula polymorpha[Biotechnology Letter,2014-10-01] -  Molecular Characterization of Acidic Peptide:N-glycanase from the Dimorphic Yeast Yarrowia lipolytica[ JOURNAL OF BIOCHEMISTRY,2015-01-01] -  The CpxRA two-component system is involved in the maintenance of the integrity of the cell envelope in the rumen bacterium Mannheimia succiniciproducens[ CURRENT MICROBIOLOGY,2015-01-01] -  Multifunctional cellulolytic auxiliary activity protein HcAA10-2 from Hahella chejuensis enhances enzymatic hydrolysis of crystalline cellulose[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2015-04-01] -  Effect of the developmental stage and tissue position on the expression and glycosylation of recombinant glycoprotein GA733-FcK in transgenic plants[FRONTIERS IN PLANT SCIENCE,2015-01-13] -  Nanomaterials for enhanced immunity as an innovative paradigm in nanomedicine[NANOMEDICINE,2015-04-01] -  Increased mannosylphosphorylation of N-glycans by heterologous expression of YlMPO1 in glyco-engineered Saccharomyces cerevisiae for mannose-6-phosphate modification[ JOURNAL OF BIOTECHNOLOGY,2015-07-01] -  Glycan structure and serum half-life of recombinant CTLA4Ig, an immunosuppressive agent, expressed in suspension-cultured rice cells with coexpression of human β1,4-galactosyltransferase and human CTLA4Ig[ GLYCOCONJUGATE JOURNAL,2015-05-01] -  Enhanced α(2,6)-sialyltransferase reaction through an inhibition of its inherent sialidase activity by dephosphorylation of cytidine-5`-monophosphate[PLOS ONE,2015-07-01] -  Glyco-engineering strategies for development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage[BMB REPORTS,2015-08-01] -  Hansenula polymorpha Hac1p Is Critical to Protein N-Glycosylation Activity Modulation, as Revealed by Functional and Transcriptomic Analyses[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2015-10-01] -  N-glycan containing a core α1,3-fucose residue is required for basipetal auxin transport and gravitropic response in rice[ NEW PHYTOLOGIST,2016-10-01] -  Effects of a Hot-Water Extract of Allium hookeri Roots on Bone Formation in Human Osteoblast-Like MG-63 Cells In Vitro and in Rats In Vivo[ PLANTA MEDICA,2016-11-01] -  Data for analysis of mannose-6-phosphate glycans labeled with fluorescent tags[Data in Brief,2016-04-01] -  Comparison of fluorescent tags for analysis of mannose-6-phosphate glycans[ ANALYTICAL BIOCHEMISTRY,2016-05-15] -  Minicircle microporation-based non-viral gene delivery improved the targeting of mesenchymal stem cells to an injury site[ BIOMATERIALS,2016-09-01] -  Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity[ BIOMATERIALS,2017-06-01] -  Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes[ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2017-04-01]

특허(최근 5년)

-  신규알콜 탈수소효소 HpADH3 및 이를 이용한 바이오에탄올 제조방법[2013-01-03] -  효모 표면 발현된 코리네박테리움 디프테리아 유래 트랜스-시알리다아제 및 이를 이용한 시알산 전구체 제조 방법[2013-01-07] -  신규알콜 탈수소효소 HpADH1 및 이를 이용한 바이오에탄올 제조방법[2013-02-28] -  외래 유전자 강제 발현 벡터[2014-01-02] -  A novel gene from Hansenula polymorpha capable of controlling unfolded protein response and method for increasing effect of secretion using the same[2012-12-04] -  한세눌라 폴리모르파 유래의 단백질 O-만노실 전이효소의 신규 유전자 및 이 유전자가 결손된 한세눌라 폴리모르파 변이주[2014-07-08] -  난분해성 유해 방향족 화합물 감지용 인공바이오센서 및 이의 제조 방법[2014-08-08] -  야로위아 리폴리티카 유래 펩티드-N-글리코시다제 및 이의 용도[2014-08-21] -  우렁쉥이(멍게) 유래의 시알산 전이효소 및 이를 이용한 시알화 복합당질 합성 방법[2014-10-28] -  HpGAS1 유전자 파쇄 효모 균주 및 이를 이용한 재조합 단백질의 생산 방법[2015-02-25] -  한세눌라 폴리모르파 게놈의 무작위 돌연변이 기술[2015-03-30] -  재설계된 감지 단백질을 이용한 유해 방향족 화합물 검출용 인공바이오센서 및 이의 제조방법[2016-02-24] -  YlMpo1 단백질을 이용한 만노스인산화 반응[2016-07-06] -  재조합 ST6Gal1 단백질을 활성형으로 제조하는 방법[2016-10-13] -  세포벽 결합 효모 변이주를 이용한 재조합 단백질 분비능이 향상된 효모 균주의 스크리닝 방법[2016-12-29] -  MyoD 단백질을 포함하는 근육 분화 유도용 조성물[2017-01-26]