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이대희 교수

Lee Daehee

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명공학
    (시스템생명공학)
  • 연락처042-879-8225
  • 출신전공생물공학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일
개인홈페이지

연구분야

합성생물학 및 대사공학

Synthetic Biology & Metabolic Engineering

대표연구실적

-  Seong Keun Kim*, Dae-Hee Lee*, Oh Cheol Kim, Jihyun F. Kim, and Sung Ho Yoon, 2017, Tunable control of an Escherichia coli expression system for the overproduction of membrane proteins by titrated expression of a mutant lac repressor, ACS Synthetic Biology 6(9): 1766?1773. -   Seong Keun Kim, Haseong Kim, Woo-Chan Ahn, Kwang-Hyun Park, Eui-Jeon Woo, Dae-Hee Lee*, Seung-Goo Lee*, 2017, Efficient transcriptional gene repression by type V-A CRISPR-Cpf1 from Eubacterium eligens, ACS Synthetic Biology 6(7):1273?1282. -  Gui Hwan Han, Wonjae Seong, Yaoyao Fu, Paul K. Yoon, Seong Keun Kim, Soon-Jin Yeom, Dae-Hee Lee*, Seung-Goo Lee*, 2017, Leucine zipper-mediated targeting of multi-enzyme cascade reactions to inclusion bodies in Escherichia coli for enhanced production of 1-butanol, Metabolic Engineering 40:41?49. ?

논문(최근 5년)

-  Generating in vivo cloning vectors for parallel cloning of large gene clusters by homologous recombination[PLoS ONE,2013-11-11] -  Molecular cloning and characterization of two novel fructose-specific transporters from the osmotolerant and fructophilic yeastCandida magnoliae JH110[Applied Microbiology and Biotechnology,2013-09-19] -  Optimizing promoters and secretory signal sequences for producing ethanol from inulin by recombinant Saccharomyces cerevisiae carrying Kluyveromyces marxianus inulinase[Bioprocess and Biosystems Engineering,2014-08-21] -  The genome organization of Thermotoga maritima reflects its lifestyle[PLoS Genetics,2013-04-25] -  A novel psychrophilic alkaline phosphatase from the metagenome of tidal flat sediments [BMC Biotechnology,2015-01-31] -  Rationmetric analyses at critical temperatures can magnify the signal intensity of FRET-based sugar sensors with periplasmic binding proteins[Biosensors and Bioelectronics,2015-10-01] -  Comparative genomics and parallel evolution reveals toxicity escape mechanisms caused by membrane protein overexpression?[Scientific Reports,2015-11-04] -  Toward complete bacterial genome sequencing through the combined use of multiple next-generation sequencing platforms[Journal of Microbiology and Biotechnology,2015-10-14] -  Fumarate-mediated persistence of Escherichia coli against antibiotics[Antimicrobial Agents and Chemotherapy,2016-04-01] -  A cell-cell communication-based screening system for novel microbes with target enzyme activities?[ACS Synthetic Biology,2016-07-25] -  CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production[Metabolic Engineering,2016-11-01] -  Fermentative production and direct extraction of (-)-alpha-bisabolol in?metabolically engineered?Escherichia coli[Microbial Cell Factories,2016-11-08] -  Long-term stable and tightly controlled expression of recombinant proteins in antibiotics-free conditions[PLoS ONE,2016-12-01] -  Production of D-ribose by metabolically engineered?Escherichia?coli??[Process Biochemistry,2017-01-02] -  Leucine zipper-mediated targeting of multi-enzyme cascade reactions to inclusion bodies in Escherichia coli for enhanced production of 1-butanol[Metabolic Engineering,2017-03-01] -  Controlled aggregation and increased stability of beta-glucuronidase by cellulose binding domain fusion[PLoS ONE,2017-01-18] -  Efficient transcriptional gene repression by type V-A CRISPR-Cpf1 from Eubacterium eligens[ACS Synthetic Biology,2017-04-04] -  Tunable control of an Escherichia coli expression system for the overproduction of membrane proteins by titrated expression of a mutant lac repressor[ACS Synthetic Biology,2017-05-19] -  Enhanced production of xylitol from xylose by expression of Bacillus?subtilis arabinose:H+?supporter and Scheffersomyces stipitis xylose reductase in recombinant Saccharomyces cerevisiae?[Enzyme and Microbial Technology,2017-12-01]

특허(최근 5년)

-  LacI 단백질 변이체를 이용한 독성 단백질의 생산 방법[2014-07-08] -  재설계 유전자회로를 이용한 아미노카프론산의 감지 및 정량 방법[2017-08-31] -  신규 카프로락탐 전환 효소 및 이를 이용한 카프로락탐 생산 방법[2017-03-07] -  단백질 융합 디스플레이 기술을 이용한 물질 간 상호작용 고속분석 방법[2017-04-28] -  재설계 유전자회로를 이용한 카프로락탐의 감지 및 정량 방법[2017-03-31] -  재설계 유전자회로를 이용한 섬유소분해효소 활성의 신규 탐색 및 정량방법[2016-07-07] -  유전자회로 설계용 부품뱅크[2015-02-23]