황정환 교수

Jung Hwan Hwang

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4633
  • 출신전공분자의학과
  • 학위박사
  • 최종출신대학충남대학교
  • 이메일

연구분야

대사질환, 폐혈증, 간질환, 염증성 장 질환, 마우스모델제작

Metabolic syndrome, liver disease, inflammatory bowel disease, generation of mouse model

대표연구실적

-  Hwang JH. et. al./Metformin ameliorates acetaminophen hepatotoxicity via Gadd45beta-dependent regulation of JNK signaling in mice/Journal of Hepatology/2015.07 -  Hwang JH. et al./The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction/Arch Toxicol/2015.04 -  Gang GT. et al./Protection of NAD(P)H:quinoen oxidoreductase 1 against renal ischemia/reperfusion injury in mice/Free Radical Biology and Medicine/2014.02

논문(최근 5년)

-  STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-02-26] -  Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model[ NEUROBIOLOGY OF DISEASE,2016-03-01] -  Reply to Repurposing of metformin in liver injury: the JNK conundrum""[ JOURNAL OF HEPATOLOGY,2016-03-01] -  NQO1-knockout mice are highly sensitive to Clostridium difficile toxin A-induced enteritis[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2016-08-28] -  Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2016-10-01] -  Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis[JOURNAL OF CELL BIOLOGY,2017-01-02] -  Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2017-01-01] -  Humulus japonicus Prevents Dopaminergic Neuron Death in 6-Hydroxydopamine-induced models of parkinson's disease[JOURNAL OF MEDICINAL FOOD,2017-02-01] -  Metformin inhibits the development of l-DOPA-induced dyskinesia in a murine midel of Parkinson's disease[MOLECULAR NEUROBIOLOGY,2018-07-01] -  Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E-deficient mice[EXPERIMENTAL AND THERAPEUTIC MEDICINE,2017-10-10] -  Small heterodimer partner deficiency exacerbates binge drinking-induced liver injury via modulation of natural killer T cell and neutrophil infiltration[MOLECULAR MEDICINE REPORTS,2018-04-01] -  Small heterodimer partner deficiency increases inflammatory liver injury through C-X-C motif chemokine ligand 2-driven neutrophil recruitment in mice[TOXICOLOGICAL SCIENCES,2018-05-01] -  Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45b-dependent manner[JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,2018-08-01] -  Effects of histone acetyltransferase inhibitors on l-DOPA-induced dyskinesia in a murine model of parkinson's disease[JOURNAL OF NEURAL TRANSMISSION,2018-09-01] -  GADD45b plays a protective role in acute lung injury by regulating apoptosis in experimental sepsis in vivo[JOURNAL OF CELLULAR PHYSIOLOGY,2018-03-01] -  Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-10-01] -  3,5-Di-C-b-D-glucopyranosyl phloroacetophenone, a major component of melicope ptelefolia, suppresses fibroblast activation and alleviates arthritis in a mouse model: potential therapeutics for rheumatoid arthritis[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-11-01] -  Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation[SCIENTIFIC REPORTS,2018-10-01] -  Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes[REDOX REPORT,2018-12-01] -  Small heterodimer partner contros the virus-mediated antiviral immune response by targeting CREB-binding protein in the nucleus[CELL REPORTS,2019-03-01] -  Glutamate signaling in hepatic stellate cells drives alcoholic steatosis[CELL METABOLISM,2019-08-20] -  Ablation of Gadd45 beta ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction[JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2020-08-24] -  Gadd45beta promotes regeneration after injury through TGFb-dependent restitution in experimental colitis[EXPERIMENTAL AND MOLECULAR MEDICINE,2019-10-30] -  A designed whole-cell biosensor for live diagnosis of gut inflammation through nitrate sensing[BIOSENSORS & BIOELECTRONICS,2020-08-20] -  The potential roles of NAD(P)H:quinone oxidoreductase 1 in the development of diabetic nephropathy and actin polymerization[SCIENTIFIC REPORTS,2020-10-20]

특허(최근 5년)

-  PspA를 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학 조성물[2016-05-30] -  환삼덩굴 추출물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 조성물[2018-04-27] -  환삼덩굴 추출물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 조성물[2016-12-06] -  가시박 추출물을 유효성분으로 포함하는 간 질환으 치료 또는 예방용 조성물[2017-11-23] -  가시박 추출물 또는 이의 분획물을 유효성분으로 포함하는 대사성 질환의 예방 또는 치료용 조성물[2017-10-27] -  방향족 케톤계 화합물, 이의 생산 방법, 및 용도[2018-07-23] -  암브로시아 아르테미시폴리아 추출물 또는 이의 분획물을 유효성분으로 포함하는 인지기능 장애 또는 신경 염증의 예방 또는 치료용 조성물[2018-08-06] -  퇴행성 뇌질환의 예방 또는 치료 효과를 가지는 아카토바쿨룸 속 균주 및 이의 용도[2017-11-15] -  퇴행성 뇌질환의 예방 또는 치료 효과를 가지는 아커만시아 뮤시니필라 균주 및 이의 용도[2017-11-15] -  뮤신이 없는 배지에서 배양한 아커만시아 뮤시니필라 균주 또는 이의 배양액을 유효성분으로 함유하는 대사성 질환의 예방, 개선 또는 치료용 조성물[2017-12-08] -  메트포민을 유효성분으로 포함하는 도파민 유발 이상운동증의 예방 또는 치료용 약학적 조성물[2018-02-06]