이희구 교수

Lee Hee Gu

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처042-860-4182
  • 출신전공면역학
  • 학위박사
  • 최종출신대학건국대학교
  • 이메일

연구분야

질환 관련 바이오마커의 발굴 및 기능연구와 이들을 이용한 진단, 치료에 관한 연구

Functional research of disease-related biomarker and diagnostic development for therapeutic target molecules

대표연구실적

-  Collagen Triple Helix Repeat Containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells/Oncotarget/2014.02.21 -  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer/Oncotarget/2014.04.29 -  Cystatin SN neutralizes the inhibitory effect of cystatin C on cathepsin B activity/CELL DEATH & DISEASE/2013.12.30

논문(최근 5년)

-  Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer[ ONCOTARGET,2016-12-20] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer[Cell Death and Disease,2017-02-14] -  Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity[ NATURE COMMUNICATIONS,2016-12-08] -  Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function[ JOURNAL OF LEUKOCYTE BIOLOGY,2016-08-12] -  Tescalcin expression contributes to invasive and metastatic activity in colorectal cancer[ TUMOR BIOLOGY,2016-08-02] -  Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases[ ACTA BIOMATERIALIA,2016-12-01] -  Antimelanogenic effect of 4-hydroxylonchocarpin through the inhibition of tyrosinase-related proteins and MAPK phosphatase[ EXPERIMENTAL DERMATOLOGY,2016-02-26] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ ONCOTARGET,2016-01-27] -  Genkwadaphnin promotes leukocyte migration by increasing CD44 expression via PKD1/NF-κB signaling pathway[ IMMUNOLOGY LETTERS,2016-03-14] -  Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer[ ONCOTARGET,2015-12-10] -  Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma[ ONCOTARGET,2016-01-22] -  G protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastric cancer[BMB REPORTS,2019-11-30] -  Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion[CANCER LETTERS,2018-03-28] -  The N-degron pathway mediates ER-phagy[MOLECULAR CELL,2019-09-05] -  Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer[Tumor Biology,2017-10-15] -  Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019-06-11] -  Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMP kinase activation[BRITISH JOURNAL OF PHARMACOLOGY,2018-12-22] -  Epsilon-Globin HBE1 enhances radiotherapy resistance by down-regulating BCL11A in colorectal cancer cells[CANCERS,2019-04-08] -  Morin hydrate reverses cisplatin resistance by impairing PARP1/HMGB1-dependent autophagy in hepatocellular carcinoma[CANCERS,2019-07-15] -  Regulation of Rho GTPases by RhoGDIs in human cancers[CELLS,2019-09-05] -  DNA replication and sister chromatid cohesion 1 (DSCC1) of the replication factor complex CTF18-RFC is critical for colon cancer cell growth[Journal of Cancer,2019-10-15] -  Erastin inhibits septic shock and inflammatory gene expression via suppression of NF-kB pathway[JOURNAL OF CLINICAL MEDICINE,2019-12-14] -  Nogo receptor-vimentin interaction: a novel mechanism for the invasive activity of glioblstoma multiforme[Experimental and Molecular Medicine,2019-10-24] -  Differential expression of tescalcin by modification of promoter methylation controls cell survival in gastric cancer cells[ONCOLOGY REPORTS,2019-04-04] -  Culin3/KCTD5 promotes the ubiquitination of Rho guanine nucleotide dissociation inhibitor 1 and regulates its stability[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2020-10-28] -  Dysregulation of Rho GTPases in human cancers[CANCERS,2020-05-07] -  Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation[BONE,2019-11-12] -  Modulation of immunosuppression by oligonucleotide-based molecules and small molecules targeting myeloid-derived suppressor cells[Biomolecules and Therapeutics,2020-01-01] -  Regulation of hematopoietic stem cell fate and malignancy[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020-07-06] -  Wnt3a stimulation promotes primary ciliogenesis through b-catenin phosphorylation-induced reorganization of centriolar satellites[CELL REPORTS,2020-02-04] -  Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability[Cell Death and Disease,2019-07-29] -  Efficient interleukin-21 production by optimization of codon and signal peptide in chinese hamster ovarian cells[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2019-02-28] -  Indoleamine-2,3-dioxygenase in thyroid cancer cells suppresses natural killer cell function by inhibiting NKG2D and NKp46 expression via STAT signaling pathways[JOURNAL OF CLINICAL MEDICINE,2019-06-12] -  Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size[Journal of Nanobiotechnology,2019-02-05] -  A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model[EXPERIMENTAL DERMATOLOGY,2018-02-02] -  Ephrin B1 promotes cancer cell migration and invasion through the interaction with RhoGDI1[ONCOGENE,2018-02-15] -  Peptide nucleic acid (PNA) probe-based analysis to detect filaggrin mutations in atopic dermatitis patients[EXPERIMENTAL DERMATOLOGY,2018-08-09] -  Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions[JOURNAL OF BIOLOGICAL CHEMISTRY,2018-01-19] -  Prostaglandin E2 secreted by thyroid cancer cells contributes to immune escape through the suppression of natural killer (NK) cell cytotoxicity and NK cell differentiation[FRONTIERS IN IMMUNOLOGY,2018-08-09] -  Small heterodimer partner deficiency increases inflammatory liver injury through C-X-C motif chemokine ligand 2-driven neutrophil recruitment in mice[TOXICOLOGICAL SCIENCES,2018-05-01] -  Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation[SCIENTIFIC REPORTS,2018-10-15] -  The ancient phosphatidylinositol 3-kinase signaling system is a master regulator of energy and carbon metabolism in algae[PLANT PHYSIOLOGY,2018-05-16] -  Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells[Oncotarget,2017-12-04] -  Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation[Cell Death and Disease,2017-04-06] -  Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARr[JOURNAL OF ENDOCRINOLOGY,2017-12-01] -  MR assessment of acute pathologic process after myocardial infarction in a permanent ligation mouse model: Role of magnetic nanoparticle-contrasted MRI [Contrast Media and Molecular Imaging,2017-10-18] -  Vitexin confers HSF-1 mediated autophagic cell death by activating JNK and ApoL1 in colorectal carcinoma cells[Oncotarget,2017-08-10] -  Von Hippel-Lindau regulates interleukin-32b stability in ovarian cancer cells[Oncotarget,2017-07-17]

특허(최근 5년)

-  감수(Euphobia kansui) 추출물, 분획물 또는 이로부터 분리한 디테르펜 화합물을 유효성분으로 하는, 상피세포의활성을유도하고상처회복에관여하는약학적조성물[2017-06-14] -  감수(Euphobia kansui) 추출물, 분획물 또는 이로부터 분리한 디테르펜 화합물을 유효성분으로 하는, 상피세포의활성을유도하고상처회복에관여하는약학적조성물[2017-06-14] -  암 치료용 약학 조성물[2015-12-22] -  심혈관 질환 마커 파랄레민 및 이를 이용한 심혈관 질환 진단 방법[2016-01-21] -  신규한 GPCR 단백질 및 이의 용도[2017-03-01] -  칼리크레인6의 발현 또는 활성 억제제를 유효성분으로 함유하는 항암제 민감성 증진용 약학적 조성물[2016-03-16] -  대장암 진단 키트 및 대장암의 예방 또는 치료용 약제학적 조성물[2017-08-31] -  코돈 최적화된 IL-21 및 이의 용도[2019-08-01] -  아실하이드라존 유도체를 포함하는 항염증 조성물[2018-03-12]

연구과제 수행 실적

NK활성화를 위한 cytokine 생산 심혈관질환 관련마커의 임상검증을 통한 진단 및 치료타겟 유효성 검증 종양유전자인 KLK6에 의한 염증 조절 및 암 미세환경에서의 기전 연구 항암제 내성 극복을 위한 종양유도 유전자들과 오토페이지의 상호조절 연구 자연살해세포 면역치료능 개선을 위한 NKp30 전사변이체 조절인자 발굴 및 기전 연구