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Pae Ae Nim

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
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연구분야

분자 설계 및 의약합성

molecular modeling and medicinal chemistry

대표연구실적

-  Shin S, Lim S, Song JY, Kim D, Choi MJ, Gadhe CG, Park AY, Pae AN, Kim YK. Deveolpment of an aryloxazole derivative as a brain Permeable Anti-Glioblastoma Agent Pharceutics, 2019, Sep 28, 11(10) E497 -  Lim JW, Kim SK, Choi SY, Kim DH, Gadhe CG, Lee HN, Kim HJ, Kim J, Cho SJ, Hwang H, Seong J, Jeong KS, Lee JY, Lim SM, Lee JW, Pae AN, Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.Eur. J. Med. Chem.2018, 157, 405, 2018 Sep 5 -  Kim T, Son WS, Morshed MN, Londhe AM, Jung SY, Park JH, Park WK, Lim SM, Park KD, Cho SJ, Jeong KS, Lee J, Pae AN, Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.2017, 141, 240, 2017, Dec. 1

논문(최근 5년)

-  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole derivative with Remarkable Broad-Spectrum Antiproliferative Activity[CHEMMEDCHEM,2016-08-05] -  Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening[Bioorganic & medicinal chemistry letters,2016-07-01] -  Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities[European journal of medicinal chemistry,2016-06-01] -  Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-02] -  Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica[CHEMMEDCHEM,2016-02-01] -  Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2016-08-01] -  Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-02-01] -  Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice[ JOURNAL OF INVESTIGATIVE DERMATOLOGY,2016-01-01] -  Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies[ JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2016-01-01] -  Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1)[EXPERT OPINION ON THERAPEUTIC PATENTS,2016-09-13] -  Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2) [EXPERT OPINION ON THERAPEUTIC PATENTS,2016-09-16] -  Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-12-01] -  α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors[ MOLECULAR PHARMACOLOGY,2016-11-01] -  "Design and synthesis of new 2-anilinoquinolines[ CHEMICAL BIOLOGY & DRUG DESIGN,2017-01-02] -  Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-01] -  Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease[Acta neuropathologica,2017-11-01] -  Direct interaction with 14-3-3 gamma promotes surface expression of Best1 channel in astrocyte[Molecular Brain,2017-11-01] -  Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity[European journal of medicinal chemistry,2017-09-21] -  In silico-designed novel non-peptidic ABAD L-D hot spot mimetics reverse Ab-induced mitochondrial impairments in vitro[Chemical biology & drug design,2017-06-04] -  Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders[European journal of medicinal chemistry,2017-10-04] -  Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity[European journal of medicinal chemistry,2017-09-22] -  Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Ab-induced mitochondrial dysfunction in Alzheimer's disease[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-01-20] -  Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B Inhibitors toward Parkinson’s disease therapy[BIOORGANIC & MEDICINAL CHEMISTRY,2018-01-01] -  A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer[CANCER LETTERS,2018-07-10] -  A Novel Phenylsulfonamide Ameliorates the Cognitive Impairment in Mice Induced by Scopolamine[BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2018-05-29] -  GRP78-targeted in-silico virtual screening of novel anticancer agents[CHEMICAL BIOLOGY & DRUG DESIGN,2018-03-18] -  Synthesis and evaluation of an orally available “Y”-shaped biaryl peroxisome proliferator-activated receptor δ agonist[BIOORGANIC & MEDICINAL CHEMISTRY,2018-07-20] -  Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain[JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2018-09-01] -  Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-08-03] -  Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study[BIOORGANIC & MEDICINAL CHEMISTRY,2018-10-09] -  Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent[PHARMACEUTICS,2019-09-01] -  Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation[BIOORGANIC CHEMISTRY,2019-09-01] -  Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists[MOLECULES,2019-09-05] -  Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator[ACS MEDICINAL CHEMISTRY LETTERS,2019-06-03] -  Gait Ignition Failure in JNPL3 Human Tau-mutant Mice[EXPERIMENTAL NEUROBIOLOGY,2019-06-26] -  Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019-03-21] -  Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease[SCIENCE ADVANCES,2019-03-15] -  Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson's Disease Therapy[JOURNAL OF MEDICINAL CHEMISTRY,2018-12-12] -  Recent tau-targeted clinical strategies for the treatment of Alzheimer’s disease[FUTURE MEDICINAL CHEMISTRY,2019-09-13] -  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities[European journal of medicinal chemistry,2016-06-01] -  Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-02] -  Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica[CHEMMEDCHEM,2016-02-01] -  Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice[ JOURNAL OF INVESTIGATIVE DERMATOLOGY,2016-01-01] -  Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies[ JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2016-01-01] -  α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors[ MOLECULAR PHARMACOLOGY,2016-11-01] -  "Design and synthesis of new 2-anilinoquinolines[ CHEMICAL BIOLOGY & DRUG DESIGN,2017-01-02]

특허(최근 5년)

-  5-HT2C 수용체 특이적 양성자방출단층촬영용 방사성 추적자 합성 방법[2018-02-07] -  구굴스테론 유도체를 포함하는 신독성 감소용 조성물[2018-01-19]