이철호 교수

Lee, Chul-Ho

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4637
  • 출신전공수의학과(예방)
  • 학위박사
  • 최종출신대학충남대학교
  • 이메일

연구분야

질환모델동물, 대사질환

Disease animal model, Metabolic disease

대표연구실적

-  Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol -  Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis -  NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats

논문(최근 5년)

-  Enhanced Th2 cell differentiation and function in the absence of Nox2[ ALLERGY,2017-02-01] -  An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction[ BIOMATERIALS SCIENCE,2017-02-01] -  Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2017-01-02] -  Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression[SCIENTIFIC REPORTS,2016-09-30] -  Analysis of the mouse gut microbiome using full-length 16S rRNA amplicon sequencing[SCIENTIFIC REPORTS,2016-06-14] -  The orphan nuclear receptor ERRγ regulates hepatic CB1 receptor-mediated fibroblast growth factor 21 gene expression[PLOS ONE,2016-06-25] -  Chemical constituents from Melicope pteleifolia leaves[ PHYTOCHEMISTRY,2016-10-01] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ONCOTARGET,2016-02-23] -  Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model[ NEUROBIOLOGY OF DISEASE,2016-05-02] -  Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection[NATURE MICROBIOLOGY,2016-10-16] -  Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity[ NATURE IMMUNOLOGY,2016-12-01] -  NQO1 inhibits proteasome-mediated degradation of HIF-1α[ NATURE COMMUNICATIONS,2016-12-14] -  NQO1-knockout mice are highly sensitive to Clostridium difficile toxin A-induced enteritis[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2016-08-28] -  Reply to ‘‘Repurposing of metformin in liver injury: The JNK conundrum”[JOURNAL OF HEPATOLOGY,2016-03-01] -  High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives[ JOURNAL OF CONTROLLED RELEASE,2016-05-28] -  Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2016-09-01] -  STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-02-26] -  Glucose-6-phosphate dehydrogenase deficiency improves insulin resistance with reduced adipose tissue inflammation in obesity[ DIABETES,2016-09-01] -  Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of tricarboxylic acid cycle anaplerosis and ketogenesis[ DIABETES,2016-10-01] -  O-GlcNAcylation of orphan nuclear receptor estrogen-related receptor γ promotes hepatic gluconeogenesis[ DIABETES,2016-10-01] -  Insulin-inducible SMILE inhibits hepatic gluconeogenesis[ DIABETES,2016-01-01] -  NQO1 deficiency leads enhanced autophagy in cisplatin-induced acute kidney injury through the AMPK/TSC2/mTOR signaling pathway[ ANTIOXIDANTS & REDOX SIGNALING,2016-05-20] -  Humulus japonicus prevents dopaminergic neuron death in 6-hydroxydopamine-induced models of Parkinson's disease[ JOURNAL OF MEDICINAL FOOD,2017-02-01] -  ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21[ JOURNAL OF ENDOCRINOLOGY,2017-04-01] -  Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis[ JOURNAL OF CELL BIOLOGY,2017-01-02] -  Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Kruppel-Like Factor 2 and Adhesion Molecules[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-02-10] -  Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression[PLOS ONE,2017-07-27] -  Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression[EXPERIMENTAL AND MOLECULAR MEDICINE,2017-12-08] -  Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E-deficient mice[EXPERIMENTAL AND THERAPEUTIC MEDICINE,2017-10-10] -  MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI[CONTRAST MEDIA & MOLECULAR IMAGING,2017-10-18] -  Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion[Cancer Letters,2018-03-28] -  Discrimination of different geographic varieties of Gymnema sylvestre, an anti-sweet plant used for the treatment of type 2 diabetes[PHYTOCHEMISTRY,2018-06-01] -  Small heterodimer partner deficiency exacerbates binge drinking-induced liver injury via modulation of natural killer T cell and neutrophil infiltration[MOLECULAR MEDICINE REPORTS,2018-04-01] -  Reduced oxidative capacity in macrophages results in systemic insulin resistance[NATURE COMMUNICATIONS,2018-04-19] -  Small Heterodimer Partner Deficiency Increases Inflammatory Liver Injury Through C-X-C motif chemokine ligand 2-Driven Neutrophil Recruitment in Mice[TOXICOLOGICAL SCIENCES,2018-02-02] -  GADD45β plays a protective role in acute lung injury by regulating apoptosis in experimental sepsis in vivo[JOURNAL OF CELLULAR PHYSIOLOGY,2018-10-01] -  Metformin Inhibits the Development of L-DOPA-Induced Dyskinesia in a Murine Model of Parkinson's Disease[MOLECULAR NEUROBIOLOGY,2018-07-01] -  Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner[ARCHIVES OF TOXICOLOGY,2018-06-25] -  Effects of histone acetyltransferase inhibitors on L-DOPA-induced dyskinesia in a murine model of Parkinson's disease[JOURNAL OF NEURAL TRANSMISSION,2018-09-01] -  Inverse agonist of ERRγ reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver[ARCHIVES OF TOXICOLOGY,2018-09-01] -  Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-10-01] -  Growth arrest and DNA-damage-inducible 45 beta (GADD45β) deletion suppresses testosterone-induced prostate hyperplasia in mice[LIFE SCIENCES,2018-10-15] -  Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation[SCIENTIFIC REPORTS,2018-10-15] -  3,5-Di-C-β-D-glucopyranosyl phloroacetophenone, a major component of Melicope ptelefolia, suppresses fibroblast activation and alleviates arthritis in a mouse model: Potential therapeutics for rheumatoid arthritis[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-11-01] -  TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress[Aging Cell,2018-12-01] -  Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes[Redox Report,2018-12-01] -  Flavone glycosides from Sicyos angulatus and their inhibitory effects on hepatic lipid accumulation[PHYTOCHEMISTRY,2019-01-01] -  Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis[NATURE MICROBIOLOGY,2019-04-01] -  Dereplication of Components Coupled with HPLC-qTOF-MS in the Active Fraction of Humulus japonicus and It's Protective Effects against Parkinson's Disease Mouse Model[Molecules,2019-04-11] -  Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus[CELL REPORTS,2019-05-14] -  Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype[FRONTIERS IN IMMUNOLOGY,2019-05-07] -  Elucidation of Akkermansia muciniphila Probiotic Traits Driven by Mucin Depletion[FRONTIERS IN MICROBIOLOGY,2019-05-22] -  Eudesmane Glycosides from Ambrosia artemisiifolia (Common Ragweed) as Potential Neuroprotective Agents[JOURNAL OF NATURAL PRODUCTS,2019-05-24] -  Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019-09-03] -  ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21[ JOURNAL OF ENDOCRINOLOGY,2017-04-01]

특허(최근 5년)

-  PspA를 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학 조성물[2016-05-30] -  환삼덩굴 추출물을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 조성물[2016-12-13] -  방향족 케톤계 화합물, 이의 생산 방법, 및 용도[2018-07-24] -  방향족 케톤계 화합물, 이를 포함하는 삼차고 추출물 또는 이의 분획물을 포함하는 관절염의 예방 또는 치료용 조성물[2019-06-04] -  EPRS 단백질 또는 이의 단편을 포함하는 항RNA-바이러스용 조성물[2018-04-24] -  뮤신이 없는 배지에서 배양한 아커만시아 뮤시니필라 균주 또는 이의 배양액을 유효성분으로 함유하는 대사성 질환의 예방, 개선 또는 치료용 조성물[2017-12-08] -  퇴행성 뇌질환의 예방 또는 치료 효과를 가지는 아커만시아 뮤시니필라 균주 및 이의 용도[2017-11-15] -  퇴행성 뇌질환의 치료 또는 예방 효과를 가지는 아가토바쿨룸 속 균주 및 이의 용도[2017-07-15] -  가시박 추출물 또는 이의 분획물을 유효성분으로 포함하는 대사성 질환의 예방 또는 치료용 조성물[2017-10-27] -   메트포민을 유효성분으로 포함하는 도파민 유발 이상운동증의 예방 또는 치료용 약학적 조성물 [2018-02-06] -   가시박 추출물을 유효성분으로 포함하는 간 질환의 치료 또는 예방용 조성물 [2017-11-23] -  지노스테마 론기페스 VK1 추출물 또는 이로부터 분리한 론기페노사이드 A 화합물을 유효성분으로 포함하는 인지기능장애 예방 또는 치료용 조성물[2017-12-14] -  암브로시아 아르테미시폴리아 추출물 또는 이의 분획물을 유효성분으로 포함하는 인지기능 장애 또는 신경 염증의 예방 또는 치료용 조성물[2018-08-06] -  세드렐라 휘실리스 추출물 또는 이의 분획물을 함유하는 대사성 질환 예방 및 치료용 조성물 [2016-06-23]

연구과제 수행 실적

고아핵수용체의 간독성 스트레스 조절에 대한 연구 차세대 첨단의료측정 플랫폼 개발을 위한 동물모델 활용기반 구축 및 지원