김선욱 교수

Sun-Uk Kim

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처043-240-6321
  • 출신전공분자생물학
  • 학위박사
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연구분야

발생공학, 줄기세포생물학, 형질전환 질환모델 개발

Developmental Biotechnology, Stem Cell Biology, Transgenic Disease Model Generation

대표연구실적

-  Choi SA, Kim YH, Park YH, Yang HJ, Jeong PS, Cha JJ, Yoon SB, Kim JS, Song BS, Lee JH, Sim BW, Huh JW, Song IS, Lee SR, Kim MK, Kim JM, Bae YS, Imakawa K, Kim SU, Chang KT. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis. Cell Death Differ. 2019 Sep;26(9):1582-1599 -  Park YH, Kim SU, Kwon TH, Kim JM, Song IS, Shin HJ, Lee BK, Bang DH, Lee SJ, Lee DS, Chang KT, Kim BY, Yu DY. Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. Oncogene. 2016 Jul 7;35(27):3503-13 -  Kim SU, Park YH, Kim JM, Sun HN, Song IS, Huang SM, Lee SH, Chae JI, Hong S, Sik Choi S, Choi SC, Lee TH, Kang SW, Rhee SG, Chang KT, Lee SH, Yu DY, Lee DS. Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells. Stem Cells. 2014 Apr;32(4):998-1011

논문(최근 5년)

-  GRK5-knockout mice generated by TALEN-mediated gene targeting[ ANIMAL BIOTECHNOLOGY,2016-08-10] -  Anti-inflammatory actions of plant-derived multiple monoclonal antibody CO17-1A × BR55 related with anti-cancer effects in AOM/DSSinduced colorectal cancer mouse via downregulating of ERK1/2[ ANIMAL CELLS AND SYSTEMS,2016-07-20] -  Macaca specific exon creation event generates a novel ZKSCAN5 transcript[ GENE,2016-02-01] -  Mitochondria-targeted DsRed2 protein expression during the early stage of bovine somatic cell nuclear transfer embryo development[ IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL,2016-06-10] -  Identification of alternative variants and insertion of the novel polymorphic AluYl17 in TSEN54 gene during primate evolution[INTERNATIONAL JOURNAL OF GENOMICS,2016-10-30] -  Ganglioside GD1a promotes oocyte maturation, furthers preimplantation development, and increases blastocyst quality in pigs[JOURNAL OF REPRODUCTION AND DEVELOPMENT,2016-02-09] -  Inhibitory effect of imiquimod-induced psoriasis-like skin inflammation in mice by histamine H4 receptor agonist 4-methylhistamine[ SCANDINAVIAN JOURNAL OF IMMUNOLOGY,2016-02-10] -  Establishment and characterization of immortalized minipig neural stem cell line[ CELL TRANSPLANTATION,2017-02-01] -  Alu-derived alternative splicing events specific to Macaca lineages in CTSF gene[MOLECULES AND CELLS,2017-02-01] -  Dual effect of fetal bovine serum on early develpment depends on stage-specific reactive oxygen species demands in pigs[PLOS ONE,2017-04-01] -  Development of a new type of recombinant hyaluronidase using a hexahistidine; possibilities and challenges in commercialization[Journal of Microbiology and Biotechnology,2019-07-30] -  Testicular endothelial cells promote self-renewal of spermatogonial stem cells in rats[BIOLOGY OF REPRODUCTION,2019-06-11] -  Increased CD68/TGFβ co-expressing microglia/macrophages after transient middle cerebral artery occlusion in rhesus monkeys [EXPERIMENTAL NEUROLOGY,2019-08-31] -  Novel porcine model of acute myocardial infarction using polyethylene terephthalate[Journal of Biomedical and Translational Research,2019-06-20] -  Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis[CELL DEATH AND DIFFERENTIATION,2018-11-21] -  Comparative evaluation of hormones and hormone-like molecule in lineage specification of human induced pluripotent stem cells[INTERNATIONAL JOURNAL OF STEM CELLS,2019-06-30] -  Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method[PLOS ONE,2019-07-22] -  Abnormal mitochondria in a non-human primate model of MPTP-induced Parkinson’s disease: Drp1 and CDK5/p25 signaling [Experimental Neurobiology,2019-06-01] -  Peroxiredoxin V inhibits emodin-induced gastric cancer cell apoptosis via the ROS/Bcl2 pathway[IN VIVO,2019-05-21] -  Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019-06-02] -  Evaluation of fecal microbiomes associated with obesity in captive cynomolgus monkeys (Macaca fascicularis)[Journal of Veterinary Science,2019-05-01] -  Influence of local myocardial infarction on endothelial function, neointimal progression, and inflammation in target and non-target vascular territories in a porcine model of acute myocardial infarction[Journal of Korean Medical Science,2019-05-20] -  Induction of cardiomyocyte-like cells from hair follicle cells in mice[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2019-03-13] -  GDNF family receptor alpha 1 is a reliable marker of undifferentiated germ cells in bulls[THERIOGENOLOGY,2019-04-16] -  Protective role of peroxiredoxin I in heat-killed Staphylococcus aureus-infected mice[IN VIVO,2019-04-08] -  Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats[ASIAN JOURNAL OF ANDROLOGY,2018-10-12] -  An antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model[CANCER IMMUNOLOGY RESEARCH,2019-02-01] -  GM1 Induced the inflammatory response related to the Raf-1/MEK1/2/ERK1/2 pathway in co-culture of pig mesenchymal stem cells with RAW264.7[Animal Cells and Systems,2018-03-22] -  The effects of kinase modulation on in vitro maturation according to different cumulus-oocyte complex morphologies[PLOS ONE,2018-10-11] -  Characterization of recombinant bovine sperm hyaluronidase and identification of an important Asn-X-Ser/Thr motif for its activity[Journal of Microbiology and Biotechnology,2018-07-19] -  Mito-TEMPO improves development competence by reducing superoxide in preimplantation porcine embryos[SCIENTIFIC REPORTS,2018-07-04] -  Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018-04-30] -  Follistatin rescues blastocyst development of poor quality porcine cumulus-oocyte complexes by delaying meiotic resumption with decreased cGMP[REPRODUCTIVE SCIENCES,2018-05-01] -  Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines[INTERNATIONAL IMMUNOPHARMACOLOGY,2018-06-01] -  Successful application of human-based methyl capture sequencing for methylome analysis in non-human primate models[BMC GENOMICS,2018-04-18] -  Perfluorooctane sulfonate exacerbates mast cell-mediated allergic inflammation by the release of histamine[Molecular and Cellular Toxicology,2018-04-01] -  Melatonin improves the meiotic maturation of porcine oocytes by reducing endoplasmic reticulum stress during in vitro maturation[JOURNAL OF PINEAL RESEARCH,2017-10-30] -  Effects of newly synthesized recombinant human amyloid-β complexes and poly-amyloid-β fibers on cell apoptosis and cognitive decline[Journal of Microbiology and Biotechnology,2017-09-15] -  Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence [BMB Reports,2017-09-12] -  House dust mite increases pro-Th2 cytokines IL-25 and IL-33 via the activation of TLR1/6 signaling[JOURNAL OF INVESTIGATIVE DERMATOLOGY,2017-09-23] -  IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways[SCIENTIFIC REPORTS,2017-09-11] -  Native plants (Phellodendron amurense and Humulus japonicus) extracts act as antioxidants to support developmental competence of bovine blastocysts[ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES,2017-09-01] -  Ganglioside GM3 induces cumulus cell apoptosis through inhibition of epidermal growth factor receptor-mediated PI3K/AKT signaling pathways during in vitro maturation of pig oocytes[MOLECULAR REPRODUCTION AND DEVELOPMENT,2017-06-02] -  Identifiation and characterization of the tyrosinase gene (TYR) and its transcript variants (TYR_1 and TYR_2) in the crab-eating macaque (Macaca fascicularis)[GENE,2017-07-26] -  Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission[MITOCHONDRION,2017-05-26] -  Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells[Molecular Medicine Reports,2017-04-12] -  Iloprost supports early development of in vitro-produced porcine embryos through activation of the phosphatidylinositol 3-kinase/AKT signalling pathway[REPRODUCTION FERTILITY AND DEVELOPMENT,2016-06-09] -  Superovulatory responses in cynomolgus monkeys (Macaca fascicularis) depend on the interaction between donor status and superovulation method used[JOURNAL OF REPRODUCTION AND DEVELOPMENT,2017-01-09]

특허(최근 5년)

-  변형 외막소포체를 포함하는 항감염성 면역증강용 조성물[2016-06-17] -  LPS가 결여된 아시네토박터 바우마니 유래 외막소포체를 포함하는 항암용 조성물[2016-06-17] -  디지토닌을 이용한 정자의 형질전환 방법[2017-02-06] -  스트렙토라이신 O의 처리에 의한 형질전환 동물의 생산성 향상 방법[2016-09-28] -  항산화 효소의 발현 또는 활성 억제제를 포함하는, 신경세포로의 분화 유도용 조성물 [2016-04-14]

연구과제 수행 실적

국가영장류센터사업 노인성 뇌질환 형질전환 동물모델 개발사업