정병화 교수

Jung Byung Hwa

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5062
  • 출신전공약학과 (약제학전공)
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

대사체학, 질량분석학, DMPK (약물대사와 약물동력학)

Metabolomics, mass spectrometric analysis, DMPK (drug metabolism and pharmacokinetics)

대표연구실적

-  Kumar BS, Chung BC, Lee YJ, Yi HJ, Lee BH, Jung BH/GC-MS-based simultaneous quantitative analytical method for urinary oxysterols and bile acids in rats/Anal. Biochem. 408, 242-252 /2011 -  howmik Salil Kumara, Young-Joo Lee, Hong Jae Yi, Bong Chul Chung, Byung Hwa Jung/Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach/Anal. Chim. Acta, 19, 661, 47-59/2010 -  정병화, 정봉철/Method for analysis of metabolite difference between two biological samples using gas chromatography-mass spectrometry/7,678,579, 미국/2010.3.16

논문(최근 5년)

-  Development of GC-MS based cytochrome P450 assay for the investigation of multi-herb interaction.[ ANALYTICAL BIOCHEMISTRY,2017-02-01] -  Novel genes in brain tissues of EAE-induced normal and obese mice: Upregulation of metal ion-binding protein genes in obese-EAE mice.[ NEUROSCIENCE,2017-02-20] -  Quantitative profiling of bile acids in rat bile using ultrahigh-performance liquid chromatography-orbitrap mass spectrometry: Alteration of the bile acid composition with aging.[ JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2016-09-15] -  Development of simultaneous analysis of tryptophan metabolites in serum and gastric juice - an investigation towards establishing a biomarker test for gastric cancer diagnosis.[ BIOMEDICAL CHROMATOGRAPHY,2016-12-01] -  A leading role for NADPH oxidase in an in-vitro study of experimental autoimmune encephalomyelitis.[ MOLECULAR IMMUNOLOGY,2016-04-01] -  Increased levels of brain serotonin correlated with MMP-9 activity and IL-4 levels resulted in severe experimental autoimmune encephalomyelitis (EAE) in obese mice.[ NEUROSCIENCE,2016-04-05] -  Metabolite identification of AZD8055 in Sprague-Dawley rats after a single oral administration using ultra-performance liquid chromatography and mass spectrometry[Journal of pharmaceutical and biomedical analysis,2017-10-01] -  Metabolite identification and pharmacokinetic profiling of PP242, an ATPcompetitive inhibitor of mTOR using ultra high-performance liquidchromatography and mass spectrometry[Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,2018-01-01] -  MVP- an open-source preprocessor for cleaning duplicate records and missing values in mass spectrometry data[FEBS OPEN BIO,2017-07-01] -  The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein[BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2017-09-01] -  Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics[CHEMISTRY AND PHYSICS OF LIPIDS,2018-08-01] -  Identification of interactions between multiple components in Socheongryong-tange using a plant profiling approach[BIOMEDICAL CHROMATOGRAPHY,2019-06-01] -  Identification of Altered Metabolic Pathways during Disease Progression in EAE Mice via Metabolomics and Lipidomics[NEUROSCIENCE,2019-09-01] -  Analysis of plasma metabolic profiling and evaluation of the effect of the intake of Angelica keiskei using metabolomics and lipidomics[JOURNAL OF ETHNOPHARMACOLOGY,2019-10-01] -  Evaluation of the antitumor effects of PP242 in a colon cancer xenograft mouse model using comprehensive metabolomics and lipidomics[SCIENTIFIC REPORTS,2020-10-16]

특허(최근 5년)

-  소청룡탕의 품질 판별 및 품질 표준화 방법[2016-03-25] -  류마티스관절염과 골관절염 감별 진단을 위한 대사체[2016-04-18] -  심혈관 질환 진단용 바이어마커 (Diagnostic metbod for cardiovascular disease)[2016-05-31] -  트립토판 대사 변화를 이용한 위암 진단용 기초 정보 제공 방법[2016-04-05] -  위암 진단용 바이오마커 조성물 및 이를 이용한 위암진단방법 (Composition of diagnostic biomarker for stomach cancer and method of diagnosing stomach cancer using the composition)[2015-12-29] -  심혈관 질환 진단용 바이오마커[2016-09-21] -  시토크롬 P450 이소효소 동시 활성 측정법[2018-01-26] -  혈액 및 위액에서의 키누레닌 대사 비율 변화를 이용한 위암 진단 기초 정보 제공[2017-11-24] -  급성관상동맥증후군 질환 진단용 다중 생체 대사체 플랫폼[2017-10-23] -  뉴로텐신 수용체의 활성을 이용하여 위암 치료용 물질을 스크리닝하는 방법[2017-07-03] -  신규한 시클릭 시트룰리네이티드 펩티드, 이를 포함하는 류마티스 관절염 진단용 조성물 및 이를 이용한 진단방법, 및 류마티스 관절염 마커 스트리닝 방법[2017-07-10] -  HMG-CoA 환원효소 저해효능이 우수한 에스터 화학반응된 섬쑥부쟁이 분획물[2017-02-27] -  Multi-metabolites platform for diagnosis of acute coronary syndrome[2018-11-06] -  생체시료내 특정 단백질의 추출법[2018-08-22] -  Cyclic citrullinated peptidem rheumatoid arthritis diagnosis composition includint the same, rheumatoid arthritis diagnosis method using the peptide or the composition, and method of screening diagnostic marker for rheumatoid arthritis[2017-04-23] -  대사체 및 임상지표를 활용한 관상동맥 심장질환 진단용 키트 및 기초정보제공방법[2019-07-18] -  대장암 치료제 발굴을 위한 신규표적 치료 작용점의 스크리닝 방법 및 이를 이용하여 선별한 대장암 치료 예휴 바이오마커[2019-07-30] -  형광검출기가 장착된 모세관 전기영동을 이용한 류마티스 관절염 진단방법[2019-06-11] -  Kit for diagnosis of coronary heart disease using multi-metabolites and clinical parameters, and method for diagnosis of coronary heart disease using the same[2019-09-10] -  ALK 또는 ROS-1 인산화 효소 억제제 스크리닝을 위한 방법, 조성물 및 키트 및 방법 [2020-10-13]