노은주 교수

Roh Eun Joo

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
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연구분야

의약화학

Medicinal chemistry

대표연구실적

-  Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy -  Lead discovery and optimization of t-type calcium channel blockers -  P2Y1 Antagonists: Combining Receptor-Based Modeling and QSAR for a Quantitative Prediction of the Biological Activity Based on Consensus Scoring

논문(최근 5년)

-  Synthesis of Novel Arylaminoquinazolinylurea Derivatives and Their Antiproliferative Activities against Bladder Cancer Cell Line[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-08-24] -  Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R[MOLECULAR CANCER THERAPEUTICS,2017-01-01] -  Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea:A new modulator for amyloid beta-induced mitochondrial dysfunction[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-03-10] -  Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library[Bioorganic chemistry,2017-10-22] -  Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders[European journal of medicinal chemistry,2017-10-04] -  Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity[European journal of medicinal chemistry,2017-09-22] -  Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of A?-induced mitochondrial dysfunction in Alzheimer's disease [EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-12-14] -  Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents [EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-03-23] -  Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-? modulators [EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-08-08] -  Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors[Bioorganic and Medicinal Chemistry Letters,2018-10-11] -  First in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl)amino)pyrimidin-5-yl)benzamide as a potential anti-tauopathies agent [EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-11-02] -  Death-associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes[MEDICINAL RESEARCH REVIEWS,2018-06-03] -  Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-beta-induced mPTP opening[EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017-04-21]

특허(최근 5년)

-  항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체[2016-01-22] -  CaM 저해활성을 가지는 페노싸이아진 유도체[2016-08-03] -  Compounds as chloride channel blocking agent[2017-12-05] -  단백질 키나아제 저해제로 유용한 헤테로아릴아민 유도체[2018-04-13] -  Phenothiazine derivatives having cam inhibitory activity[2018-07-31] -  항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는 약학조성물[2019-01-02] -  JAK-3저해제로 유용한 7H-피롤로[2,3-d]피리미딘-4-싸이올유도체[2016-11-30] -  Phenoxypropanol derivative and pharmaceutical composition including the same[2016-10-04] -  Heteroarylamine derivatives as protein kinase inhibitors[2017-03-07] -  아릴옥시 아제티딘 화합물, 및 이를 포함하는 약학 조성물[2016-08-23] -  단백질 키나아제 저해제인 신규 피라졸로피리딘 유도체 또는 인다졸 유도체[2019-01-03]