김선영 교수

Kim Seon Young

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8116
  • 출신전공미생물학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

유전체학, 생물정보학, 후성유전체학

genomics, bioinformatics, epigenomics

대표연구실적

-  Kim SK, Kim JH, Yun SJ, Kim WJ, and Kim SY* (2014) APPEX: analysis platform for the identification of prognostic gene signatures in cancer Bioinformatics, 30(22): 3284-6 -  Kim M, Park YK, Kang TW, Lee SH, Rhee YH, Park JL, Lee D, Lee D, Kim SY* and Kim YS* (2014) Dynamic changes in DNA methylation and hydromethylation when hES cells undergo differentiation toward a neuronal lineage, Hum Mol Genet: 23(3):657-67 -  Lee KS, Park JL, Lee K, Richardson LE, Johnson BH, Lee HS, Lee JS, Kim SB, Kwon OH, Song KS, Kim YS, Ashktorab H, Smoot DT, Jeon SH*, Kim SY*, and Lee YS* (2014) nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer Oncotarget, 5(11): 3944-3955

논문(최근 5년)

-   Improving gene-set enrichment analysis of RNA-seq data with small replicates[PLOS ONE,2016-11-09] -  Genome-wide functional analysis using the barcode sequence alignment and statistical analysis (Barcas) tool[BMC BIOINFORMATICS,2016-10-03] -   A proteogenomic approach for protein-level evidence of genomic variants in cancer cells[SCIENTIFIC REPORTS,2016-10-13] -  GSF2 deletion increases lactic acid production by alleviating glucose repression in Saccharomyces cerevisiae[SCIENTIFIC REPORTS,2016-10-06] -   Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity[ NATURE IMMUNOLOGY,2016-11-01] -  Identification of molecular subtypes and significantly mutated genes in gastric cancer using next-generation sequencing[TRANSLATIONAL CANCER RESEARCH,2016-06-01] -  Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer[WORLD JOURNAL OF GASTROENTEROLOGY,2016-01-21] -   LATS-YAP/TAZ controls lineage specification by regulating TGFb signaling and Hnf4a expression during liver development[NATURE COMMUNICATIONS,2016-06-30] -  ZKSCAN3 facilitates liver metastasis of colorectal cancer associated with CEA-expressing tumors[ ANTICANCER RESEARCH,2016-07-01] -  Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancer.[ JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2016-08-01] -  Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer.[PLOS ONE,2016-05-06] -  Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes [ INTERNATIONAL JOURNAL OF ONCOLOGY,2016-06-01] -   Identification and evaluation of age-correlated DNA methylation markers for forensic use[FORENSIC SCIENCE INTERNATIONAL-GENETICS,2016-07-23] -  Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer [Oncotarget,2016-05-03] -  Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites[Oncotarget,2016-02-16] -  Gpr171 expression enhances proliferation and metastasis of lung cancer cells[Oncotarget,2016-02-16] -   Integrated Genomic Analysis of Recurrence-Associated Small Non-coding RNAs in Oesophageal Cancer[ GUT,2017-02-01] -  MRTF potentiates TEAD-YAP transcriptional activity causing metastasis[ EMBO JOURNAL,2017-02-15] -  A late-lineage murine neutrophil precursor populationk exhibits dynamic changes during demand-adapted granulopoiesis[SCIENTIFIC REPORTS,2017-01-06] -  Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III[EPIGENOMICS,2017-02-01] -  A basal-like breast cancer-specific role for SRF-IL16 in YAP-induced cancer stemness[NATURE COMMUNICATIONS,2015-12-16] -  Epigenetic regulation of KLHL34 predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients[ INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2016-03-01] -  Intrinsic Molecular Processes: Impact on Mutagenesis[Trends in Cancer,2017-05-31] -  Variability in chromatin architecture and associated DNA repair at genomic positions containing somatic mutations[CANCER RESEARCH,2017-06-01] -  PSMB8 as a candidate marker of responsiveness to preoperative radiation therapy in rectal cancer patients[INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2017-08-01] -   Improvement of D-Lactic acid production in Saccharomyces cerevisiae under acidic conditions by evolutionary and rational metabolic engineerin[BIOTECHNOLOGY JOURNAL,2017-10-31] -  Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene[Oncotarget,2017-07-21] -   Integrative analysis for the discovery of lung cancer serological markers and validation by MRM-MS [PLOS ONE,2017-08-24] -  Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis[ONCOGENE,2017-12-07] -  Transcriptomic features of primary prostate cancer and their prognostic relevance to castration-resistant prostate cancer[Oncotarget,2017-11-06] -  The LncRNA EPEL Promotes Lung Cancer Cell Proliferation Through E2F Target Activation[Cellular Physiology and Biochemistry,2018-02-15] -  Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer[JOURNAL OF CLINICAL INVESTIGATION,2018-03-01] -  nc886 is induced by TGF-b and suppresses the microRNA pathway in ovarian cancer[Nature Communications,2018-03-31] -  VAP/TAZ initiates gastric tumorigenesis via upregulation of MYC[CANCER RESEARCH,2018-06-15] -  Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype[Nature Communications,2018-05-03] -  Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer[Cancer Medicine,2018-06-04] -  Vitamin C promotes astrocyte differentiation through DNA hydroxymethylation[STEM CELLS,2018-07-13] -  Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion respectively[PLoS ONE,2018-08-27] -  Long noncoding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 depositin for transcription-associated heterochromatin reorganization[NUCLEIC ACIDS RESEARCH,2018-12-14] -  Dynamic transcriptome, DNA methylome, and DNA hydroxymethylome networks during T-cell lineage commitment[MOLECULES AND CELLS,2018-11-01] -   Bcl-2-dependent synthetic lethal interaction of hte IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer[BRITISH JOURNAL OF CANCER,2018-11-30] -  Whole genome MBD-seq and RRBS analyses reveal that hypermethylation of gastrointestinal hormone receptors is associated with gastric carcinogenesis[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-12-03] -   Toll-like receptor 4 activation suppresses autophagy through inhibition of FoxO3 and impairs phagocytic degradation of microglia[AUTOPHAGY,2019-05-01] -  CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures[MOLECULES AND CELLS,2019-03-31] -  Biclustering analysis of transcriptome big data identifies condition-specific microRNA targets[NUCLEIC ACIDS RESEARCH,2019-03-21] -  A threonyl-tRNA synthetase-mediated translation initiation machinery [NATURE COMMUNICATIONS,2019-05-22] -   Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer[World Journal of Gastroenterology,2019-03-21] -   Mechanism mediated by a noncoding RNA, nc886, in the cytotoxicity of a DNA-reactive compound[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019-04-23] -  GScluster: network-weighted gene-set clustering analysis[BMC GENOMICS,2019-05-09] -  HOXC10 overexpression promotes cell proliferation and migration in gastric cancer[ONCOLOGY REPORTS,2019-05-17] -  GENT2: an updated gene expression database for normal and tumor tissues[BMC MEDICAL GENOMICS,2019-07-11] -  Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway[MOLECULES AND CELLS,2019-08-19] -  Gpr171 expression enhances proliferation and metastasis of lung cancer cells[Oncotarget,2016-02-16] -  A basal-like breast cancer-specific role for SRF-IL16 in YAP-induced cancer stemness[NATURE COMMUNICATIONS,2015-12-16] -  Epigenetic regulation of KLHL34 predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients[ INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2016-03-01]

연구과제 수행 실적

대용량 유전자 시그너처 기반의 조절 네트워크, pathway 및 약물유전체 통합 분석 시스템 개발 효모 기반 약물작용점 분석의 생물정보 분석 시스템 개발