원미선 교수

Won, Misun

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4178
  • 출신전공미생물 분자생물학
  • 학위박사
  • 최종출신대학University of Wisconsin-Madison
  • 이메일

연구분야

암생물학, 항암제 개발, 암치료 타겟 발굴 및 기능 연구

Cancer biology, Development of anti-cancer drugs, identification and functional analysis of therapeutic targets of cancer.

대표연구실적

-  Identification of Malate Dehydrogenase?2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes.Angewante Chemie 2013. 52, 10286-10289 -  Analysis of a genome-wide set of gene deletions in the fission yeast S. pombe, Nature Biotechnology 2010, 28, 617-623 -  DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion. BBA-Gene Regulatory /mechanism 2016

논문(최근 5년)

-  DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion [ BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2016-07-10] -  Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells[CELL DEATH & DISEASE,2017-01-12] -  A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration [PLOS ONE,2016-09-01] -  Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300 [ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2016-07-21] -  Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells [Data in Brief,2016-09-06] -  Identification of targets of the HIF-1 inhibitor IDF-11774 using alkyne-conjugated photoaffinity probes [ BIOCONJUGATE CHEMISTRY,2016-07-07] -  Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)[EXPERT OPINION ON THERAPEUTIC PATENTS,2016-02-16] -  DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer[ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2016-01-01] -  Antioxidant activities of distiller dried grains with solubles as protein films containing tea extracts and their application in the packaging of pork meat[ FOOD CHEMISTRY,2016-04-01] -  Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer [BRITISH JOURNAL OF CANCER,2018-11-13] -  DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells[ONCOGENE,2017-12-15] -  RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivation[CELL DEATH & DISEASE,2018-05-01] -  Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel[ACTA BIOMATERIALIA,2017-09-28] -  The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth[CELL DEATH & DISEASE,2017-06-01] -  Methyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a novel and dual malate dehydrogenase (MDH) 1/2 inhibitor targeting cancer metabolism[JOURNAL OF MEDICINAL CHEMISTRY,2017-10-02] -  Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells[Bioorganic and Medicinal Chemistry Letters,2017-05-01]

특허(최근 5년)

-  신규한 이치환 아다만틸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암전이 억제용 약학적 조성물[2016-09-20] -  Pharmaceutical composition for treating cancer[2015-12-22] -  DDIAS 및 STAT3의 상호작용을 이용한 암 치료제 스크리닝 방법 [2016-01-28] -  신규한 퀸옥살린 유도체 및 이의 용도 [2016-07-21] -  H I F-1 α 활성을 저해하는 신규 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학조성물 [2016-06-15] -  H I F-1 α 활성을 저해하는 신규 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학조성물 [2016-12-09] -  Compounds as HIF-1alphainhibitors and manufacturing process thereof[2016-04-19] -  Novel compounds as HIF-1alphainhibitors and manufacturing process thereof[2016-02-25] -  암 치료 또는 전이 타겟으로서 VGLL1의 용도[2017-03-03] -  Genome-wide construction of Schizosaccharomyces pombe heterozygous deletion mutants containing gene-specific barcodes by the methods of 4-round serial or block PCR, or total gene synthesis thereof[2017-06-06] -  NOVEL COMPOUNDS AS HIF-1ALPHA INHIBITORS AND MANUFACTURING PROCESS[2017-11-08] -  Pharmaceutical composition for preventing and treating cancer, containing cyb5r3 gene or protein as active ingredient[2017-11-08] -  Compounds as HIF-1α inhibitors and manufacturing process thereof[2017-10-17] -  HSP70 탐지용 프로브 및 이의 제조방법[2018-12-11]

연구과제 수행 실적

DDIAS knockdown이 매개하는 폐암세포의 죽음 조절 네트웍 규명