이현규 교수

Lee Hyeon Kyu

INFO

  • 소속캠퍼스한국화학연구원 스쿨
  • 전공 의약화학 및 약리생물학
    (의약화학)
  • 연락처042-860-7016
  • 출신전공화학
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일
개인홈페이지

연구분야

의약화학, 유기화학, 비대칭합성

Medicinal Chemistry, Organic Chemistry, Asymmetric Synthesis

대표연구실적

-  Se-Mi Son, Hyeon-Kyu Lee,* “Dynamic Kinetic Resolution Based Asymmetric Transfer Hydrogenation of 2-Benzoyl-Morpholinones and Its Use in Concise Stereoselective Synthesis of All Four Stereoisomers of the Anti-depressant Reboxetine”, J. Org. Chem. 2013, 78, 8396. -  Juae Han, Soyeong Kang, Hyeon-Kyu Lee.* “Dynamic Kinetic Resolution in the Stereoselective Synthesis of 4,5-Diaryl Cyclic Sulfamidates by Using Chiral Rhodium-Catalyzed Asymmetric Transfer Hydrogenation”, Chem. Comm., 2011, 47, 4004-4006. -  Hyeon-Kyu Lee*, Eun Bok Choi, and Chwang Siek Pak, “The Current Status and Future Perspectives of Studies of Cannabinoid Receptor 1 Antagonists as Anti-Obesity Agents.” Curr. Top. Med. Chem. 2009, 9, 482-503.

논문(최근 5년)

-  Stereoselective synthesis of 1,3-disubstituted isoindolines via Rh(III)-catalyzed tandem oxidative olefination-cyclization of 4-aryl cyclic sulfamidates[ CHEMICAL COMMUNICATIONS,2016-01-27] -  Stereoselective synthesis of functionalized 1,3-disubstituted isoindolines via Rh(III)-catalyzed tandem oxidative olefination-cyclization of 4-aryl-cyclic sulfamidate-5-carboxylates[ JOURNAL OF ORGANIC CHEMISTRY,2017-07-03] -  Tandem Rh-catalyzed oxidative C-H olefination and cyclization of enantiomerically enriched benzo-1,3-sulfamidates: Stereoselective synthesis of trans-1,3-disubstituted isoindolines[JOURNAL OF ORGANIC CHEMISTRY,2018-03-15] -  DBU-Promoted Dynamic Kinetic Resolution in Rh-Catalyzed Asymmetric Transfer Hydrogenation of 5-Alkyl Cyclic Sulfamidate Imines: Stereoselective Synthesis of Functionalized 1,2-Amino Alcohols[JOURNAL OF ORGANIC CHEMISTRY,2018-09-10] -  Stereoselective synthesis of highly functionalized 5- and 6-membered aminocyclitols starting with a readily available 2-azetidinone.[JOURNAL OF ORGANIC CHEMISTRY,2019-03-14]

특허(최근 5년)

-  당뇨병 치료용 약학적 조성물[2017-05-11] -  1.3-치환된 이소인돌린 유도체 및 이의 입체선택적 제조방법[2017-12-06] -  고 입체순도를 갖는 4-치환된-5-원고리-설파미데이트-5-포스포네이트 화합물 및 이의 제조방법[2017-12-28] -  벤조설파미데이트-퓨즈드-이소인돌린 화합물 및 이의 입체선택적 제조[2020-03-09] -  DUSP1 활성의 알로스테릭 저해 기작을 갖는 화합물과 이의 의약학적 응용[2018-07-23]

연구과제 수행 실적

고수준 신약소재 확보를 통한 화합물은행 고도화사업 화합물 연구성과물 확보 관리 및 활용