추현아 교수

Hyunah Choo

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5157
  • 출신전공Pharmaceutical & Biomedical Sciences
  • 학위박사
  • 최종출신대학Univ Georgia
  • 이메일

연구분야

의약화학, 유기합성화학

Medicinal Chemistry, Organic Synthesis

대표연구실적

-  Kim, Y.; Kim, H.; Lee, J.; Lee, J. K.; Min, S.-J.; Seong, J.; Rhim, H.; Tae, J.; Kim H. J.; Choo, H., Journal of Medicinal Chemistry, 2018, 61, 7218-7233 -  Ha, T.; Kim, M. K.; Park, K.-s.; Jung, W.; Choo, H.; Chong, Y., Journal of Agricultural and Food Chemistry, 2018, 66, 3850-3859 -  Lee, Y. M.; Kim, M. K.; Choo, H.; Chong, Y., Journal of Agricultural and Food Chemistry, 2018, 66, 12741-12747

논문(최근 5년)

-  Novel N-acyl-carbazole derivatives as 5-HT7R antagonists[European journal of medicinal chemistry,2016-01-25] -  Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability[Bioorganic & medicinal chemistry letters,2016-05-27] -  Quercetin 7-O-Glutamate Potentiates Staphylococcus aureus to Fluoroquinolone Antibiotics[Bulletin of the Korean Chemical Society,2016-08-31] -  A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer's Disease[ACS CHEMICAL NEUROSCIENCE,2016-08-30] -  5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-07-21] -  Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-01] -  Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT6 receptor antagonists[Bioorganic & medicinal chemistry letters,2017-07-11] -  Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease[Acta neuropathologica,2017-06-07] -  A Potential PET radiotracer for the 5-HT2C receptor: Synthesis and in vivo evaluation of 4-(3-[F-18]Fluorophenethoxy)pyrimidine[ACS CHEMICAL NEUROSCIENCE,2017-02-14] -  Facile synthesis of 4"-O-alkyl-(-)-EGCG derivatives through ragioselective deacetylatitve alkylation[SYNTHETIC COMMUNICATIONS,2017-01-19] -  A difluoroboron beta-diketonate probe shows "turn-on" near-infrared fluoroscence specific for tau fibrils[ACS CHEMICAL NEUROSCIENCE,2017-07-24] -  Indole-substituted benzothiazoles and bezoxazoles as selective and reversible MAO-B inhibitors for treatment of Parkinsons's disease[ACS CHEMICAL NEUROSCIENCE,2017-03-23] -  Discoery of beta-arrestin biased lignads of 5-HT7R[JOURNAL OF MEDICINAL CHEMISTRY,2018-07-20] -  Structural Modification of (-)-epigallocatechin gallate (EGCG) shows significant enhancement in mitochondrial biogenesis[JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018-03-08] -  Synthesis of N-alkyl-carbazole derivatives as 5-HT7R antagonists[BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2018-08-21] -  Enhanced catalytic activity of (DMSO)2PtCl2 for the methane oxidation in the SO3-H2SO4 system[ACS CATALYSIS,2018-11-08] -  Condensation of pentose-derived furan compounds to C15 fuel precursors using supported phosphotungstic acid catalysts: Strategy for designing heterogeneous acid catalysts based on the acid strength and pore structures[APPLIED CATALYSIS A-GENERAL,2019-01-25] -  Conjugation with phenylalanine enhances autophagy-inducing activity of (-)-Epigallocatechin gallate in hepatic cells[JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018-11-12] -  Identification of optically active pyrimidine derivatives as slective 5-HT2C modulators[MOLECULES,2017-08-26]

특허(최근 5년)

-  mGluR5의 표식용 방사성 조성물[2015-12-16] -  Thienopyrimidinone derivatives as mGluR1 antagonists[2016-02-16] -  Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same[2016-11-30] -  알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물[2016-11-21] -  5-HT7 수용체에 작용하는 카바졸 유도체[2016-10-31] -  Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same[2016-10-18] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2016-10-05] -  5탄당 유래 퓨란계 화합물 및 6탄당 유래 퓨란계 화합물의 중합체 제조용 촉매 및 이를 이용한 중합체 제조방법[2017-09-06] -  메탄올 전구체 생성용 촉매 조성물, 이를 이용하여 생성된 메탄올 전구체 및 메탄올[2018-01-29] -  5-HT2C 수용체 특이적 양성자방출단층촬영용 방사성 추적자 합성 방법[2018-02-07] -  5-HT7 수용체에 작용하는 바이페닐 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 약학조성물[2017-11-02] -  mGluR5 길항제로서의 활성을 가지는 티아졸-2-카르복사마이드 유도체[2018-03-07] -  Quinoline derivatives for inhibiting histone methyltransferases and use thereof[2018-05-29] -  5-HT7 수용체 조절제로 작용하는 아제핀 유도체[2018-11-05] -  Catalyst for producing methanol precursor, methanol precursor produced using the catalyst and methanol produced using the methanol precursor[2018-11-27] -  히스톤 메틸전달효소 저해용 퀴놀린 유도체 및 이의 용도[2019-04-01] -  5-HT7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물[2019-08-20]