지승욱 교수

Chi Seung-Wook

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (단백체구조생물학)
  • 직급전공책임교수
  • 연락처042-860-4277
  • 출신전공생명과학
  • 학위박사
  • 최종출신대학한국과학기술원
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연구분야

단백질 구조생물학, 구조기반 신약개발, 나노포어 바이오센싱

Protein Structural Biology, Structure-Based Drug Development, Nanopore biosensing

대표연구실적

-  Single-Molecule-Based Detection of Conserved Influenza A virus RNA Promoter Using a Protein Nanopore (ACS Sensors, ’19.11) -  Kwak et al., Probing the Small-Molecule Inhibition of an Anticancer Therapeutic Protein-Protein Interaction Using a Solid-State Nanopore (Angew. Chem. Int. Ed. '16.05) -  Ha et al., Molecular Mimicry-Based Repositioning of Nutlin-3 to Anti-Apoptotic Bcl-2 Family Proteins (J. Am. Chem. Soc. '11.01)

논문(최근 5년)

-  High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-09-23] -  Probing the small-molecule inhibition of an anticancer therapeutic protein-protein interaction using a solid-state nanopore[ ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016-05-04] -  Set7/9, a methltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-08-15] -  A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition[ DISEASE MODELS & MECHANISMS,2016-08-01] -  Structural insight into the critical role of the N-terminal region in the catalytic activity of Dual-Specificity Phosphatase 26[ PLOS ONE,2016-09-01] -  Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells[ BMB REPORTS,2016-10-31] -  Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protin Bcl-XL[ ORGANIC & BIOMOLECULAR CHEMISTRY,2017-09-07]

연구과제 수행 실적

나노스케일 및 구조 기반 MCMT 분자표적 발굴 나노이온소자 적용을 위한 단백질 기반 바이오컨텐츠 설계 및 활용 기술 개발 단백질 서열 분석을 위한 나노포어 기반 단백질 측정 연구 질환표적의 구조 기반 기능제어 기술 개발