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Dae-Ro Ahn

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-6645
  • 출신전공생유기화학
  • 학위박사
  • 최종출신대학Univ Bern
  • 이메일

연구분야

생명의료기술을 위한 핵산화학

Nucleic acid chemistry for innovative biomedical technology

대표연구실적

-  Kim KR, Kang SJ, Lee AY, Hwang D, Park M, Park H, Kim S, Hur K, Chung HS, Mao C, Ahn DR* /Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery/Biomaterials, 2019, 195, 1-12 -  Kim KR, Kim DR, Lee T, Yhee JY, Kim BS, Kwon IC, Dae-Ro Ahn*/Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs/Journal of Controlled Release, 2016, 243, 121-131 -  Kyoung-Ran Kim, Taemin Lee, Byeong-Su Kim and Dae-Ro Ahn*/Utilizing the bioorthogonal base-pairing system of l-DNA to design ideal DNA nanocarriers for enhanced delivery of nucleic acid cargos/Chemical Science, 2014, 5, 1533-1537

논문(최근 5년)

-  Utilization of a pH-responsive DNA motif for beta-lactamase assays[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-04-01] -  Overcoming doxorubicin resistance of cancer cells by Cas9-mediated gene disruption[SCIENTIFIC REPORTS,2016-03-01] -  Nano-formulation of a photosensitizer using a DNA tetrahedron and its potential for in vivo photodynamic therapy[BIOMATERIALS SCIENCE,2016-04-01] -  Biophysical and chemical handles to control the size of DNA nanoparticles produced by rolling circle amplification[BIOMATERIALS SCIENCE,2016-07-01] -  A fluorogenic substrate of beta-lactamases and its potential as a probe to detect the bacteria resistant to the third-generation oxyimino-cephalosporins[ BIOSENSORS & BIOELECTRONICS,2016-03-01] -  Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs[ JOURNAL OF CONTROLLED RELEASE,2016-12-01] -  Fluorogenic nanoreactor assembly with boosted sensing kinetics for timely imaging of cellular hydrogen peroxide[ CHEMICAL COMMUNICATIONS,2016-01-01] -  NMR-based Fragment Screening of Inhibitors Against p300 CH1 and HIF-1 CTAD Interaction[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-10-01] -  Modular delivery of CpG-incorporated lipid-DNA nanoparticles for spleen DC activation[ BIOMATERIALS,2017-01-01] -  Backbone-modified oligonucleotides for tuning the cellular uptake behaviour of spherical nucleic acids[BIOMATERIALS SCIENCE,2017-03-01] -  Poly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption[JOURNAL OF CONTROLLED RELEASE,2017-03-28] -  In vitro and in vivo behavior of DNA tetrahedrons as tumor-targeting nanocarriers for doxorubicin delivery[COLLOIDS AND SURFACES B-BIOINTERFACES,2017-09-01] -  Reversible Regulation of Enzyme Activity by pH-Responsive Encapsulation in DNA Nanocages[ACS NANO,2017-09-26] -  Streptavidin-mirror DNA tetrahedron hybrid as a platform for intracellular and tumor delivery of enzymes[JOURNAL OF CONTROLLED RELEASE,2018-06-28] -  Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer[MOLECULES,2018-07-23] -  Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity.[CHEMICAL COMMUNICATIONS,2018-08-21] -  Modulating α-synuclein fibril formation using DNA tetrahedron nanostructures[BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2019-01-01] -  Chimeric crRNAs with 19 DNA residues in the guide region show the retained DNA cleavage activity of Cas9 with potential to improve the specificity[CHEMICAL COMMUNICATIONS,2019-03-19] -  L-DNA linear duplex: an efficient drug delivery carrier with a simple structure[JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,2019-06-25] -  Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery[BIOMATERIALS,2019-03-01] -  Performance of a novel fluorogenic chimeric analog for the detection of third-generation cephalosporin resistant bacteria[JOURNAL OF MICROBIOLOGICAL METHODS,2016-12-01]

특허(최근 5년)

-  신규 세포투과성 펩타이드 및 이의 용도[2016-08-05] -  시료 내 약물-내성 박테리아 검출용 프로브 및 이의 용도[2018-02-08] -  효소 단백질의 활성을 가역적으로 조절 하기 위한 pH 반응성 조성물 및 그의 용도 [2019-01-23] -  생체 내 효소 단백질 전달을 위한 핵산 구조체 및 그의 용도[2019-04-22] -  자가 -조립식 폴리 리보뉴클레오단백질 나노입자[2018-11-05] -  변형 핵산을 표피로 하는 신규 코어-쉘 나노입자[2017-10-27] -  핵산 물질의 팩킹 방법[2017-09-03] -  항체, 항원 동시 검출을 위한 다중 면역분석방법[2016-09-23] -  신규한 산성 및 염기성 pH-반응성 턴-온 프로브 컨쥬게이트 및 이의 용도[2019-04-11] -  생체조직 및 세포 특이적 DNA 나노구조 약물 전달체와 이의 용도[2017-07-03] -  신규 세포투과성 펩타이드 및 이의 용도[2016-10-19] -  L-DNA 나노케이지 구조를 가지는 약물 전달체[2018-03-20] -  조영제 조성물 및 이를 이용한 바이오 영상화 방법[2017-06-06] -  JAK-3 저해제로 유용한 7H-피롤로[2,3-d]피리미딘-4-싸이올 유도체[2016-11-30]