함정엽 교수

Ham, Jungyeob

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
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연구분야

천연물화학, 천연물전환, 붕소응용반응, 전합성, 의약화학

Natural Products Chemistry, Natural Products Conversion, Organotrifluoroborates Chemistry, Total Synthesis, Medicinal Chemistry

대표연구실적

-  함정엽/Protective Effects of Processed Ginseng and Its Active Ginsenosides on Cisplatin-Induced Nephrotoxicity: In Vitro and in Vivo Studies/Journal of Agricultural and Food Chemistry/2015-07 -  함정엽/Efficient and Rapid Regioselective One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from In Situ Generated Potassium Arylethynyltrifluoroborates through Sonogashira Reaction/European Journal of Organic Chemistry/2013-10 -  함정엽/Potassium (E)-Alkenylaryltrifluoroborates: Orthogonal Functionalization of Haloaryltrifluoroborates via Heck-Mizoroki Reaction/Advanced Synthesis & Catalysis/2013-08

논문(최근 5년)

-  Comparison of the Wound-Healing Effects of Ginsenosides, their Metabolites, and Aglycones[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-01-15] -  Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells[EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016-03-03] -  Increase in apoptotic effect of Panax ginseng by microwave processing in human prostate cancer cells: in vitro and in vivo studies[Journal of Ginseng Research,2016-01-01] -  Synthesis of 3,4,5-Trimethoxybenzene Derivatives with Substituted Triazole Group by Huisgen 1,3-Cycloaddition and their Inhibitory Effects on 3T3-L1 Adipocyte Differentiation[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-08-01] -  Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-12-01] -  An Optimized and General Synthetic Strategy to Prepare Arylnaphthalene Lactone Natural Products from Cyanophthalides[ EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2017-02-01] -  Combined treatment with zingerone and its novel derivative synergistically inhibits TGF-beta 1 induced epithelial-mesenchymal transition, migration and invasion of human hepatocellular carcinoma cells[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-02-01] -  Three-Component One-Pot Synthesis of Unsymmetrical Diarylalkynes by Thermocontrolled Sequential Sonogashira Reactions Using Potassium Ethynyltrifluoroborate[EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2017-05-01] -  Regioselective Synthesis of the FXR Antagonist E-Guggulsterone from Three Natural Steroids[Bulletin of the Korean Chemical Society,2017-05-15] -  Evaluation of guggulsterone derivatives as novel kidney cell protective agents against cisplatin-induced nephrotoxicity[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-07-01] -  Renoprotective Effects of Hypoxylonol C and F Isolated from Hypoxylon truncatum against Cisplatin-Induced Cytotoxicity in LLC-PK1 Cells[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018-03-01] -  Stimulation of Innate Immune Function by Panax ginseng after Heat Processing[JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018-05-15]

특허(최근 5년)

-  속수자 추출물을 함유하는 흉터 개선용 조성물[2016-05-10] -  마이크로웨이브 조사에 의한 페놀성화합물 배당체의 탈당화 반응을 통한 효능강화 천연물 추출물 및 그 조성물의 제조방법, 및 그 가공 천연물 추출물을 포함하는 조성물[2016-03-02] -  아릴나프탈렌 리그난 유도체를 함유하는 치매 예방 및/또는 치료용 조성물[2015-12-15] -  몬소니아속 식물 추출물을 함유하는 치매 예방 또는 치료용 조성물[2016-02-23] -  고삼 추출물을 함유하는 숙취 예방 또는 해소용 조성물[2016-02-03] -  구글스테론 유도체의 제조방법 및 그를 포함하는 항암제 조성물 [2016-07-01] -  아미노산을 이용한 파낙스속 식물의 신규 열처리 가공방법[2017-09-01] -  구굴스테론 유도체를 포함하는 신독성 감소용 조성물[2018-01-19] -  미세조류 배양체 추출물을 유효성분으로 함유하는 생리활성(피부암, 항염증, NF-kB, 신장보호) 조성물[2018-02-28]