이규선 교수

Kyu-Sun Lee

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4429
  • 출신전공동물학
  • 학위박사
  • 최종출신대학중앙대학교
  • 이메일

연구분야

성인만성질환 치료 기술 개발

Develop therapeutics for age-related diseases

대표연구실적

-  이규선외/Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development/Developmental Cell/2016.08 -  이규선외/Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway/Genes&Development/2013.12 -  이규선외/Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling/NatureCellBiology/2008.04

논문(최근 5년)

-  Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development[DEVELOPMENTAL CELL,2016-04-18] -  A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition[DISEASE MODELS & MECHANISMS,2016-08-01] -  High fat diet-induced TGF-beta/Gbb signaling provokes insulin resistance through the tribbles expression[SCIENTIFIC REPORTS,2016-08-03] -  The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain[ PLOS GENETICS,2017-05-17] -  Neuropeptide Y mitigates ER stress-induced neuronal cell death by activating the PI3K-XBP1 pathway[EUROPEAN JOURNAL OF CELL BIOLOGY,2017-06-01] -  Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo disease models[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018-09-05] -  Prominin-like regulates longevity and glucose metabolism via insulin signaling in Drosophila[JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2018-12-26] -  Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in Zebrafish [DISEASE MODELS & MECHANISMS,2019-05-23] -  Extension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling[AGING-US,2019-10-30] -  Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis[FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020-02-05] -  Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy[AUTOPHAGY,2020-01-22]

특허(최근 5년)

-  CX-4945를 유효성분으로 함유하는 퇴행성 뇌질환 예방 및 치료용약학적조성물[2017-02-03] -  아스파라기닐 tRNA 합성효소의 발현 또는 활성을 억제하는 물질을 포함하는, 암의 예방 또는 치료용 약학적 조성물[2019-06-04] -  아스파라기닐 tRNA 합성효소 (Asparaginyl tRNA synthetase, NRS)의 발현 또는 활성을 억제하는 물질을 포함하는, 암의 예방 또는 치료용 약학적 조성물[2019-06-04] -  피롤로-피리딘 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물[2018-09-03]

연구과제 수행 실적

세포소기관 기반 생체에너지 항상성 조절 연구 표현형 기반 MSC (Multi-tRNA Synthetase Complex) 구성인자의 유전학적 상호작용 연구 세포소기관 막접촉점 형성 조절 미토콘드리아 이동단백질에 의한 세포활성 및 병리기전 연구