홍영수 교수

Hong Young Soo

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처043-240-6144
  • 출신전공분자생물학
  • 학위박사
  • 최종출신대학부산대학교
  • 이메일

연구분야

이차대사산물 조합생합성

Biosynthesis of microbial secondary metabolites

대표연구실적

-  Sun-Young Kang et al. Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain. Microbial Cell Factories 11(1), 153 (2012) -  Cheng-Zhu Wu et al. Enzymatic Glycosylation of Nonbenzoquinone Geldanamycin Analogs via Bacillus UDP-Glycosyltransferase Appl. Environ. Microbiol. 78(21):7680-7686 (2012) -  Young-Soo Hong et al. Inactivation of the carbamoyltransferase gene refines the post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin. J. Am. Chem. Soc. 126(36) 11142-11143 (2004)

논문(최근 5년)

-  Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase[Archives of Pharmacal Research,2015-12-05] -  Biosynthesis of Novel Glucosides Geldanamycin Analogs by Enzymatic Synthesis[Journal of Microbiology and Biotechnology,2016-01-28] -  Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library[ JOURNAL OF ANTIBIOTICS,2016-12-21] -  De novo biosynthesis of pterostilbene in an Escherichia coli strain using a new resveratrol O-methyltransferase from Arabidopsis[ MICROBIAL CELL FACTORIES,2017-02-15] -  Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field[ PHYTOCHEMISTRY,2016-01-01] -  New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006[ MARINE DRUGS,2016-04-02] -  Characterization of Xylobiose- and Xylopentaose-Producing β-1,4-Endoxylanase SCO5931 from Streptomyces coelicolor A3(2) [ APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2016-05-05] -  Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells[ JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2016-09-22] -  Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013[ JOURNAL OF NATURAL PRODUCTS,2016-10-11] -  Production of Bacterial Quorum Sensing Antagonists, Caffeoyl- and[Journal of Microbiology and Biotechnology,2017-12-28] -  Sam5, a Coumarate 3-Hydroxylase from Saccharothrix espanaensis: New Insight into the Piceatannol Production as a Resveratrol 3'-Hydroxylase.[ CHEMISTRYSELECT,2017-10-02]

특허(최근 5년)

-  4-하이드록시스티렌 및 이의 유사체의 생산능을 가지는 형질전환체 및 이의 생산 방법[2016-12-07] -  페닐아세틸 호모세린 락톤 유도체의 생산 방법[2017-04-06] -  레스베라트롤 글루코사이드 유도체 생합성용 컨스트럭트 및 이를 이용한 생산방법 [2016-02-01] -  메틸전이효소 암호화 폴리뉴클레오티드 및 이를 이용한 메틸화 스틸벤 화합물의 생산방법 [2016-01-07]

연구과제 수행 실적

인공 다중 효소반응의 발현비율 최적화를 통한 페닐프로판노이드계 유용물질 생산 기술 개발 한천분해효소 데그에이 과발현 방선균 균주 개발 항암 표적 단백질 및 항암 선도물질 발굴