이진혁 교수

Lee, Jinhyuk

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생명정보학)
  • 연락처042-879-8530
  • 출신전공물리화학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일
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연구분야

빅데이터 인공지능을 이용한 신약개발 후보물질 발굴, 단백질 구조 모델링, 분자동력학 시뮬레이션, 가상 스크리닝

Big data driven based on AI drug candidate discovery, Protein Structure modeling, Molecular dynamics simulation, Protein-Ligand docking

대표연구실적

-  Z J Wang, S Ji, Y X Si, J M Yang, G Y Qian, Jinhyuk Lee, S J Yin?(2013)?"The effect of validamycin A on tyrosinase: Inhibition kinetics and computational simulation"?INT J BIOL MACROMOL.?55(0)?:?15-23. -  T R Kim, Sunyoung Ji, Sanghyuk Lee, In-Sun Chu, S Shin, Jinhyuk Lee?(2012)?"A hybrid modeling strategy using Nuclear Overhauser Effect data with contact information"?CHEM PHYS LETT.?554(0)?:?190-194. -  T R Kim, Sangho Oh, Joshua Sungwoo Yang, Sanghyuk Lee, S Shin, Jinhyuk Lee?(2012)?"A simplified homology-model builder toward highly protein-like structures: An inspection of restraining potentials"?J COMPUT CHEM.?33(24)?:?1927-1935.

논문(최근 5년)

-  Effects of cadmium on the cuttlefish Sepia pharaonis arginine kinase: unfolding kinetics integrated with computational simulations[ JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2016-01-01] -  Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors[ JOURNAL OF FUNCTIONAL FOODS,2015-12-02] -  Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis[ MOLECULAR NEURODEGENERATION,2016-01-01] -  Designing an Antibody-based Chaperoning System through Programming the Binding and Release of Folding Intermediate[ ACS CHEMICAL BIOLOGY,2016-06-01] -  Integration of Inhibition Kinetics and Molecular Dynamics Simulations: A Urea-Mediated Folding Study on Acetaldehyde Dehydrogenase 1[ APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2016-05-01] -  Effect of Cadmium Ion on alpha-glucosidase: An inhibition kinetics and molecular dynamics simulation integration study[ PROTEIN JOURNAL,2016-05-05] -  A computational integrating kinetic study on the flexible active site of human acetaldehyde dehydrogenase 1[ PROCESS BIOCHEMISTRY,2016-03-15] -  Anti-obesity effects of spiramycin in vitro and in vivo[ PLOS ONE,2016-07-11] -  Effect of Cd2+ on tyrosinase: integration of inhibition kinetics with computational simulation[ INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016-09-11] -  Identification of biochanin A as a potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitor[ NUTRIENTS,2016-10-14] -  Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination With Other Gene Mutations[ SCIENTIFIC REPORTS,2016-10-06] -  Systematic approach in identifying RHOA as a Potential Asian Gastric Cancer Biomarker Therapeutic Target[ ONCOTARGET,2016-10-28]