김보연 교수

Bo Yeon Kim

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처043-240-6163
  • 출신전공분자생물
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

암신호전달, 항암제발굴, 골다공증, 단백질분해

Cancer Signaling, Anticancer drug discovery, Osteoporosis. Protein degradation

대표연구실적

-  Shashikanth M. Sriram, Bo Yeon Kim, and Yong Tae Kwon*. The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nature Reviews Molecular Cell Biology, 12(11), 735-747, 2011.. -  Takafumi Tasaki , Sung Tae Kim , Adriana Zakrzewska , Bo Eun Lee , Minjueng Kang , Young Dong Yoo , Joonsung Hwang , Nak Kyun Sung , Minh Dang Nguyen , Ming Sun , Eugene Yi , Bo-Yeon Kim*, Yong Tae Kwon*. UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc.Natl. Acad. Sci, USA, 110(10), 3800-3805, 2013. -  Haidan Liu, Kangdong Liu, Zunnan Huang, In-Ja Ryoo, Chan-Mi Park, Long He, Sun-Ok Kim, Naomi Oi, Ki-Won Lee, Nak-Kyun Soung, Ann M.Bode, Raymond L. Erikson, Zigang Dong*, Bo-Yeon Kim*. A chrysin derivative suppresses EGF-induced anchorage-independent growth of mouse epidermal JB6 P+ cells by inhibiting Cdks. J. Biol. Chem, 288(36), 25924-25937. 2013.

논문(최근 5년)

-  p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis[NATURE COMMUNICATIONS,2017-08-15] -  Anticancer activity of a novel small molecule tubulin inhibiotr STK899704[ONCOTARGET,2016-11-15] -  Crystal structure of SP-PTP, a low mulecular weight protein tyrosine phsphatase from Streptocuccus pyogenes[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-08-19] -  Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM2, a subunit of ESCRT-0[PLOS ONE,2016-03-13] -  Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/Bip[AUTOPHAGY,2016-03-01] -  The argynylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins[AUTOPHAGY,2016-04-01] -  Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptocuccus pyogenes[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-10-01] -  Stachybotrysin, and Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013[JOURNAL OF NATURAL PRODUCTS,2016-10-11] -  New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006[MARINE DRUGS,2016-09-01] -  Ginsenoside Re ihibits osteoclast differentiation in mouse bone marrow-derived macrophages and zebrafish scale model[MOLECULES AND CELLS,2016-12-06] -  Inhibitory effect of withaferin A on Helicobacter pylori-induced IL-8 production and NF-kB activation in gastric epithelial cells[MOLECULAR MEDICINE REPORTS,2016-09-01] -  Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway[ONCOGENE,2016-10-26] -  Epigenetic modification of TLR4 promotes activation of NF-kB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer[Oncotarget,2016-03-10] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[Oncotarget,2016-03-01] -  IGF-II induced by hepatitis B virus X protein regulates EMT via SUMO mediated loss of E-cadherin in mice[Oncotarget,2016-08-30] -  Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer[Oncotarget,2016-12-20] -  Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field[PHYTOCHEMISTRY,2016-03-08] -  Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM12, a subunit of ESCRT-O[PLoS ONE,2016-03-01] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutatiione reductase activity in colorectal cancer[Cell Death and Disease,2017-02-01] -  Glioma-derived cancer stem cells are hypersentitive to proteasomal inhibition[EMBO REPORTS,2017-02-01] -  Polyketides and anthranilic acid possessing 6-deoxy-a-L-talopyranose from a Streptomyces species[JOURNAL OF NATURAL PRODUCTS,2017-07-13] -  Genomics-deriven discovery of chlorinated cyclic hexapeptides Ulleungmycins A and B from a streptomyces species[JOURNAL OF NATURAL PRODUCTS,2017-10-30] -  The fungal metabolite Brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly[MOLECULES AND CELLS,2017-06-14] -  Ginsenoside Re promotes osteoblast differentiation in mouse osteoblastprecursor MC3T3-E1 cells and a zebrafish model[MOLECULES,2017-02-01] -  Anticancer activityh of a novel small molecule tubulin inhibitor STK899704[PLOS ONE,2017-03-15] -  MMPP attenuates non-small cell lung cancer growth by inhibiting the STAT3 DNA-binding activity via direct binding to the STAT3 DNA-binding domain[THERANOSTICS,2017-10-16] -  Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer[Tumor Biology,2017-10-17] -  Regulation of autophagic proteolysis byh the N-recognin SQSTM1/p62 of the N-end rule pathway[AUTOPHAGY,2018-03-01] -  PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5[AUTOPHAGY,2018-10-01] -  STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells[BMB REPORTS,2018-11-01] -  Protein phosphatase 1B dephosphoryates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion[CANCER LETTERS,2018-03-01] -  A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model[EXPERIMENTAL DERMATOLOGY,2018-04-01] -  Peptide nucleic acid (PNA) brobe-based analyusis to detect filaggrin mutations in atopic dermatitis patients[EXPERIMENTAL DERMATOLOGY,2018-10-01] -  The novel small molecule STK899704 promotes senescence of the human A549 NSCLC cells by inducing DNA damage responses and cell cycle arrest[FRONTIERS IN PHARMACOLOGY,2018-04-16] -  The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome[JOURNAL OF CELL SCIENCE,2018-09-01] -  Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions[JOURNAL OF BIOLOGICAL CHEMISTRY,2018-07-01] -  mTORC1 promotes metabolic reprogramming by the suppression of GSK3-dependent Foxk1 phosphorylation[MOLECULAR CELL,2018-06-07] -  Trichostatin A resistance is facilitated by HIF-1a acetylation in HeLa human cervical cancer cells under normoxic conditions[Oncotarget,2018-02-01] -  Vitexin induces apoptosis by suppressing autophagy in multi-drug resistanct colorectal cancer cells[Oncotarget,2018-03-01] -  The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins[PLOS ONE,2018-10-01] -  N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018-03-05] -  The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation[SCIENCE SIGNALING,2018-02-01] -  Synthesis of Clitocybin A, B and C and their biological evaluation for antioxidant activities[BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2019-03-01] -  Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019-05-01] -  Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP131, in cervical cancer[BMB REPORTS,2019-06-03] -  Epsilon-Globin HBE1 enhances radiotherapy resistance by down-regulating BCL11A in colorectal cancer cells[CANCERS,2019-06-25] -  Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability[Cell Death and Disease,2019-07-23] -  Regulation of Rho GTPase by RhoGDIs in human cancers[CELLS,2019-05-01] -  Mechanism of the naturla product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1a inhibition[Experimental and Molecular Medicine,2019-06-01] -  Erastin inhibits septic shock and inflammatory gene expression via suppression of the NF-kB pathway[JOURNAL OF CLINICAL MEDICINE,2019-08-01] -  Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity[JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2019-04-01] -  Efficient interleukin-21 production by optimization of codon and signal peptide in chinese hamster ovarian cells[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2019-07-01] -  The N-degron pathway mediates ER-phagy[MOLECULAR CELL,2019-09-01] -  Vitamin E-conjugated phosphopeptide inhibitor of the Polo-box domain of Polo-Like Kinase 1[MOLECULAR PHARMACEUTICS,2019-09-01] -  Molecular architecture of a cylindrical self-assembly at human centrosomes[NATURE COMMUNICATIONS,2019-05-01] -  Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019-10-01] -  Regulation of reticulophagy by the N-degron pathway[AUTOPHAGY,2020-03-20] -  Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibition[BIOCHEMICAL PHARMACOLOGY,2020-05-01] -  Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinbacterium Catenulispora species[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2020-05-01] -  Inhibition of osteoclasts differentiation byh CDC2-induced NFATc1 phosphorylation[BONE,2020-05-01] -  Wnt3a stimulation promotes primary ciliogenesis through b-catenin phosphorylation-induced regorganization of centriolar satellites[CELL REPORTS,2020-04-01] -  CPPE, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020-10-01] -  CRM646-A, a fungal metabolite, induces neleus condensation by increasing Ca2+ levels in rat 3Y1 fibroblast cells[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2020-08-01]

특허(최근 5년)

-  p62 ZZ 도메인에 결합하는 리간드 또는 아르기닌화된 Bip에 의해 매개되는 오토파지 활성을 통한 신경변성 질환 예방 및 치료[2017-04-25] -  Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-Carbohydrazide derivatives as an active ingredient[2016-09-06] -  신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물[2016-10-26] -  페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물[2017-03-24] -  필라그린 유전자 돌연변이 검출용 프로브, 키트 및 방법[2016-06-24] -  해양 진균에서 분리한 페니실리놀라이드 A를 유효성분으로 함유하는 염증성 질환 예방 및 치료용 조성물[2016-05-06] -  신규 튜뷸린 중합 저해제 및 그 합성방법[2016-01-06] -  아르기닌화된 ER 단백질에 특이적으로 결합하는 항체 및 이의 용도[2017-05-04] -  p62 ZZ 영역에 의해 매개되는 자가포식 조절방법 및 그 용도[2016-02-04] -  신규한 푸사리세틴 화합물 및 이의 용도[2016-06-22] -  신규한 인돌 유도체 및 이를 포함하는 항암 조성물[2017-10-19] -  Tubulin polymerization inhibitor and methd for synthesizing same[2017-05-09] -  신규한 세스퀴터펜 유도체, 이의 제조방법 및 이를 유효성분으로 하는 골 질환의 예방 또는 치료용 약학 조성물[2017-12-21] -  아실하이드라존 유도체를 포함하는 항염증 조성물[2018-03-12] -  코돈 최적화된 IL-21 및 이의 용도[2019-08-01] -  신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물[2019-06-04] -  푸사리세틴 화합물을 포함하는 피부 미백용 조성물[2018-10-16] -  고리형 헥사펩타이드계 화합물들 및 이의 용도[2019-06-04]

연구과제 수행 실적

창의형융합연구사업(에피프로테옴 기반 발암 및 암전이 치료 신규 원천기술 개발)