양현옥 교수

Yang, Hyun Ok

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
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  • 출신전공생약학
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

생약학, 천연물신약 소재 탐색, 퇴행성뇌질환

Pharmacogmogy, Natural Medicine, Neurodegenerative diseases, Anri- Alzheimer's disease, Antti- Parkinson's diseases

대표연구실적

-  양현옥, 제주상사화 추출물을 함유하는 퇴행성 신경 질환의 예방 및/또는 치료용 조성물,10-1119220(등록번호-한국, 2011.12.07), 5323640 (등록번호-일본, 2013) -  양현옥, 아릴나프탈렌 리그난 유도체를 함유하는 치매 예방 및/또는 치료용 조성물, 10-1373155(등록번호-한국, 2014), 2712615 (등록번호-유럽, 2015) -  Nayoung Bae, Hyun Ok Yang (교신저자) et al., (2015), Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's Disease, Journal of Ethonopharmacology, Vol 159, PP. 93-101(2015)

논문(최근 5년)

-  Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model[Journal of ethnopharmacology,2015-12-01] -  The Neuroprotective Effects of Justicidin A on Amyloid Beta25-35-Induced Neuronal Cell Death Through Inhibition of Tau Hyperphosphorylation and Induction of Autophagy in SH-SY5Y Cells[Neurochemical research,2016-02-18] -  The Neuroprotective Effect of Erythropoietin on Rotenone-Induced Neurotoxicity in SH-SY5Y Cells Through the Induction of Autophagy[Molecular neurobiology,2016-08-01] -  The phosphodiesterase 5 inhibitor, KJH-1002, reverses a mouse model of amnesia by activating a cGMP/cAMP response element binding protein pathway and decreasing oxidative damage [BRITISH JOURNAL OF PHARMACOLOGY,2018-05-14] -  7-Deoxy-trans-dihydronarciclasine Reduces β-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer's Disease[MOLECULAR NEUROBIOLOGY,2018-12-03] -  Glycyrrhiza uralensis and Semilicoisoflavone B reduces Aβ secretion by increasing PPARγ Expression and inhibiting STAT3 phosphorylation to inhibit BACE1 expression[Molecular Nutrition and Food Research,2018-03-02] -  7?Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models[JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019-08-08] -  Licoflavonol reduces Aβ secretion by increasing BACE1 phosphorylation to facilitate BACE1 degradation [Molecular Nutrition and Food Research,2019-01-11] -  Potential of South African medicinal plants targeting the reduction of Aβ42 protein as a treatment of Alzheimer's disease[JOURNAL OF ETHNOPHARMACOLOGY,2019-03-01] -  Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease[JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017-04-03] -  Cerebrospinal Fluid Levels of Autophagy-related Proteins Represent Potentially Novel Biomarkers of Early-Stage Parkinson’s Disease[Scientific Reports,2018-11-15] -  Anodal transcranial direct current stimulation prevents methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)- induced neurotoxicity by modulating autophagy in an in vivo mouse model of Parkinson’s disease [Scientific Reports,2018-10-11] -  Autophagic modulation by rosuvastatin prevents rotenone-induced neurotoxicity in an in vitro model of Parkinson’s disease[NEUROSCIENCE LETTERS,2017-01-27] -  Aldose reductase inhibitors attenuate β-amyloid-induced TNF-α production in microlgia via ROS-PKC-mediated NF-κB and MAPK pathways [INTERNATIONAL IMMUNOPHARMACOLOGY,2017-09-04] -  Justicidin A reduces b-amyloid via inhibiting endocytosis of b-amyloid precursor protein [Biomolecules and Therapeutics,2018-10-11] -  Anti-neuroinflammatory effects of 12-dehydrogingerdione in LPS-activated microglia through inhibiting Akt/IKK /NF-κB pathway and activating Nrf-2/HO-1 pathway[Biomolecules and Therapeutics,2018-10-26] -  Identification of interactions between multiple components in Socheongryong­-tang using a plant profiling approach[BIOMEDICAL CHROMATOGRAPHY,2019-06-03]

특허(최근 5년)

-  Composition containing arylnaphthalene lignan derivative for preventing and/or treating dementia[2015-12-15] -  Composition for preventing or treating dementia comprising extracts of monsonia species[2016-02-23] -  For preventing and / or relieving hangovers flavescens extract composition comprising[2016-02-03] -  참빗살나무 추출물을 포함하는 인지장애 관련 질환의 예방 또는 치료용 조성물[2018-07-06] -  용안육 추출물을 함유하는 숙취 예방 또는 해소용 조성물[2018-06-07] -  개오동나무 추출물을 함유하는 숙취 예방 또는 해소용 조성물[2017-03-29] -  소청룡탕의 품질판별 및 품질 표준화방법[2016-03-25] -  마이크로웨이브 조사에 의해 진세노사이드 알지3, 알지5 및 알케이1의 함량비율이 증가된 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물[2019-09-02] -  A method of preparing a panax spp. plant extract with increased content ratio of ginsenoside rg3, rg5, and rk1 produced by microwave irradiation[2019-08-07] -  Extract of Lycoris chejuenis and/or a compound isolated therefrom for preventing and/or treating[2017-05-03]