황은미 교수

Eun Mi Hwang

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생체신경과학)
  • 연락처02-958-7216
  • 출신전공신경과학
  • 학위박사
  • 최종출신대학아주대학교
  • 이메일

연구분야

이온 통로 단백질의 상호작용 연구

Interactomics of ion channels

대표연구실적

-  Hwang EM, Kim E, Yarishkin O, Woo DH, Han KS, Park N, Bae Y, Woo J, Kim D, Park M, Lee CJ, Park JY. A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Nat Commun. 2014;5:3227. 2014 Feb 5 -  Cho CH, Kim E, Lee YS, Yarishkin O, Yoo JC, Park JY, Hong SG, Hwang EM. Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death. Mol Brain. 7:52. 2014 Jul 22 -  Woo DH, Han KS, Shim JW, Yoon BE, Kim E, Bae JY, Oh SJ, Hwang EM, Marmorstein AD, Bae YC, Park JY, Lee CJ. TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Cell. 151(1):25-40. 2012 Sep 28

논문(최근 5년)

-  Suppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells[Scientific Reports,2016-05-01] -  Surface expression of the Anoctamin-1 (ANO1) channel is suppressed by protein-protein interactions with β-COP[Biochemical and biophysical research communications,2016-06-01] -  Neuronal Expression and Cell-Type-Specific[Experimental Neurobiology,2016-06-30] -  Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-12-02] -  The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons.[NATURE COMMUNICATIONS,2016-12-19] -  Optogenetic Inhibition of the Subthalamic[STEREOTACTIC AND FUNCTIONAL NEUROSURGERY,2016-03-11] -  Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation[ JOURNAL OF NEUROSCIENCE,2017-03-15] -  Modulation of Endothelial BMPR2 Activity by VEGFR3 in Pulmonary Arterial Hypertension[ CIRCULATION,2017-03-29] -  Emerging Roles of TWIK-1 Heterodimerization in the Brain[International journal of molecular sciences,2018-01-01] -  Direct interaction with 14-3-3 gamma promotes surface expression of Best1 channel in astrocyte[Molecular Brain,2017-11-01] -  Expression of μ-Opioid Receptor in CA1 Hippocampal Astrocytes[EXPERIMENTAL NEUROBIOLOGY,2018-04-02] -  PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells[Pflugers Archiv European Journal of Physiology,2018-06-21] -  TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia[SCIENTIFIC REPORTS,2018-08-02] -  Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes[FRONTIERS IN CELLULAR NEUROSCIENCE,2018-09-27] -   TWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells.[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-11-12] -  Surface expression of TTYH2 is attenuated by direct interaction with β-COP[BMB REPORTS,2019-01-23] -  14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors[EXPERIMENTAL NEUROBIOLOGY,2019-02-15] -  Downregulation of CHIP promotes ovarian cancer metastasis by inducing Snail-mediated epithelial-mesenchymal transition[MOLECULAR ONCOLOGY,2019-05-15] -  The E3 ubiquitin ligase, NEDD4L (NEDD4-2) regulates bestrophin-1 (BEST1) by ubiquitin-dependent proteolysis[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2019-06-18] -  Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain[EXPERIMENTAL NEUROBIOLOGY,2019-04-29] -  ANO1/TMEM16A regulates process maturation in radial glial cells in the developing brain[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019-05-30] -  TTYH1 and TTYH2 Serve as LRRC8A-Independent Volume-Regulated Anion Channels in Cancer Cells[CELLS,2019-07-09] -  Anoctamin 1/TMEM16A controls intestinal Cl- secretion induced by carbachol and cholera toxin[EXPERIMENTAL AND MOLECULAR MEDICINE,2019-08-05] -  The Knockdown of TREK-1 in Hippocampal Neurons Attenuate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019-11-24] -  Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease[CURRENT BIOLOGY,2020-01-20] -  TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors[EMBO REPORTS,2020-02-05] -  Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia[CELL BIOCHEMISTRY AND FUNCTION,2020-03-02] -  Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression[CELLS,2020-04-26] -  NELL2 Function in Axon Development of Hippocampal Neurons[MOLECULES AND CELLS,2020-06-30]

특허(최근 5년)

-  망막의 ON/OFF 이극세포 선택적 유전자 발현 방법[2016-02-05] -  종양치료의 병용치료로서 ANO1 단백질의 세포막이동을 억제하는 방법[2017-05-24] -  Cre 재조합효소 의존적으로 TREK-1 발현이 억제되는 항우울 동물모델 및 이의 제조방법[2020-07-02] -  리포칼린-2의 선택적 과발현을 통한 염증형성 형질전환 동물모델 및 그의 제조방법[2020-09-09] -  신규 주의력결핍 과대행동장애 생쥐모델의 개발과 응용[2020-09-15] -  우울증 또는 뇌전증 동물 모델과 그 제조방법 및 이를 이용한 우울증 또는 뇌전증 치료용 후보약물의 스크리닝 방법[2020-11-30] -  조현병 동물모델 및 이의 제조방법[2020-11-20]