이선진 교수

Seon-Jin Lee

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8293
  • 출신전공분자세포생화학
  • 학위박사
  • 최종출신대학강원대학교
  • 이메일

연구분야

오토페이지, 암 바이오마커, 종양미세환경

Autophagy, tumor biomarker, tumor microenvironment

대표연구실적

-  Lee SJ, Smith A, Guo L, Alastalo TP, Li M, Sawada H, Liu X, Chen ZH, Ifedigbo E, Jin Y, Feghali-Bostwick C, Ryter SW, Kim HP, Rabinobitch M, and Choi AM (2011) Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med. 183(5): 649-658. -  Lee SJ, Kim HP, Jin Y, Choi AM, and Ryter SW (2011) Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy -  Lee SJ, Zhang M, An CH, Xu JF, Joshi B, Nabi IR, Choi AM and Jin Y (2011) Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic Biol Med. 50(10):1252-1262.

논문(최근 5년)

-  Trichostatin A sensitizes hepatocellular carcinoma cells to enhanced NK cell-mediated killing by regulating immune-related genes[ CANCER GENOMICS & PROTEOMICS,2017-07-20] -  Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer[ ONCOTARGET,2016-11-15] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer[Cell Death and Disease,2017-03-16] -  Tescalcin expression contributes to invasive and metastatic activity in colorectal cancer[ TUMOR BIOLOGY,2016-08-02] -  Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases[ ACTA BIOMATERIALIA,2016-09-15] -  Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer[ ONCOTARGET,2016-01-27] -  Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer[ ONCOTARGET,2015-12-10] -  Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer[Cancer Biomarkers,2017-10-26] -  Ephrin B1 promotes cancer cell migration and invasion through the interaction with RhoGDI1[Cancer Biomarkers,2017-10-26] -  Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor-1 and suppresses cancer cell migration and invasion[Cancer Biomarkers,2017-10-25] -  Vitexin confers HSF-1 mediated autophagic cell death by activating JNK and ApoL1 in colorectal carcinoma cells[ ONCOTARGET,2017-08-10] -  Distal Vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension[JCI INSIGHT,2016-06-02] -  Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells[Oncotarget,2017-12-04] -  The Ancient phosphatidylinositol 3-kinase signaling system is a master regulator of energy and carbon metabolism in algae[PLANT PHYSIOLOGY,2018-07-13] -  Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation[SCIENTIFIC REPORTS,2018-10-15] -  Novel natural killer cell-mediated cancer immunotherapeutic activity of anisomycin against hepatocellular carcinoma cells[SCIENTIFIC REPORTS,2018-07-13] -  Small Heterodimer Partner Deficiency Increases inflammatory liver injury through C-X-C motif chemokine ligand 2-driven neutrophil recruitment in mice[TOXICOLOGICAL SCIENCES,2018-04-27] -  Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells [BMB reports,2019-10-01] -  G protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastriccancer [BMB reports,2019-04-08] -  Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in colorectal cancer cells[CANCERS,2019-04-08] -  Dynamic Interactions between Autophagosomes and Lipid Droplets in Chlamydomonas reinhardtii[CELLS,2019-08-08] -  Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-kB Pathway[JOURNAL OF CLINICAL MEDICINE,2019-12-11] -  Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size[Journal of Nanobiotechnology,2019-10-11] -  Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin[Cell Death and Disease,2020-07-02] -  Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions[FEBS JOURNAL,2020-03-11]

특허(최근 5년)

-  심혈관 질환 마커 파랄레민 및 이를 이용한 심혈관 질환 진단 방법[2016-01-21] -  칼리크레인6의 발현 또는 활성 억제제를 유효성분으로 함유하는 항암제 민감성 증진용 약학적 조성물[2016-03-16] -  심혈관 질환 마커 파랄레민 및 이를 이용한 심혈관 질환 진단 방법 [2018-06-26] -  코돈 최적화된 IL-21 및 이의 용도 [2019-08-01] -  코돈 최적화된 IL-21 및 이의 용도[2018-01-26] -  Sf9 생산세포주유래 재조합인플엔자 NP 발현벡터, 단백질 및 최적화 발현 시스템 구축 기술[2019-08-07]