김장환 교수

Janghwan Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4478
  • 출신전공미생물 분자유전학
  • 학위박사
  • 최종출신대학충남대학교
  • 이메일
개인홈페이지

연구분야

줄기세포, 리프로그래밍, 직접교차분화, 신경계 분화, 세포운명전환

Stem cells, Reprogramming, Direct lineage reprogramming, Neural differentiation, Cell fate change

대표연구실적

-  Zhu S, ...Kim J.*, Ding S.* (2014) Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Research 24(1): 126-129 *Corresponding -  Kim, J., et al. (2011) Direct reprogramming of mouse fibroblasts to neural progenitors. Proc. Natl. Acad. Sci. USA 108(19):7838-43 -  Kim, J., et al. (2003). A TRPV family ion channel required for hearing in Drosophila. Nature 424, 81-84

논문(최근 5년)

-  Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses [ ANTIVIRAL RESEARCH,2015-12-01] -  Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system[ BIOMATERIALS,2015-12-01] -  Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles[TOXICOLOGY AND APPLIED PHARMACOLOGY,2016-05-15] -  Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-06-03] -  Plasma-Treated Flexible Aminoclay-Decorated Electrospun Nanofibers for Neural Stem Cell Self-Renewal[ JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016-02-01] -  Vertical nanocolumn-assisted pluripotent stem cell colony formation with minimal cell-penetration[NANOSCALE,2016-10-27] -  Distinctive genomic signature of neural and intestinal organoids from familial Parkinson’s disease patient-derive induced pluripotent stem cells[NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,2017-12-01] -  Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids[NATURE COMMUNICATIONS,2018-08-02] -  Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation[Stem Cell Research,2018-06-09] -  LRRK2 impairs autophagy by mediating phosphorylation of leucyl­tRNA synthetase[CELL BIOCHEMISTRY AND FUNCTION,2018-11-08] -  Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum[MOLECULAR BIOSYSTEMS,2017-06-21] -  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models[HEPATOLOGY,2017-06-22] -  Inactivation of human DGAT2 by oxidative stress on cysteine residues[PLOS ONE,2017-07-11] -  Modelling APOE ?3/4 allele-associated sporadic Alzheimer's disease in an induced neuron[BRAIN,2017-08-01] -  Comparative analysis of human embryonic stem cell derived neural stem cells as an in vitro human model[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-02-01] -  Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by euphorbia extracts[JOURNAL OF FUNCTIONAL FOODS,2018-03-01] -  In vitro and in vivo imaging and tracking of intestinal organoids from human-induced pluripotent stem cells[FASEB JOURNAL,2018-01-01] -  A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-12-06] -  An antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model[CANCER IMMUNOLOGY RESEARCH,2019-02-01] -  Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer[ONCOLOGY REPORTS,2019-03-01] -  A SMN2 Splicing Modifier Rescues the Disease Phenotypes in an In Vitro Human Spinal Muscular Atrophy Model[STEM CELLS AND DEVELOPMENT,2019-04-01] -  Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer[MOLECULAR MEDICINE REPORTS,2019-06-26] -  Blockade of STAT3 causes severe in vitro and in vivo maturation defects in intestinal organoids derived from human embryonic stem cells[JOURNAL OF CLINICAL MEDICINE,2019-07-04] -  Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids[JOURNAL OF HEPATOLOGY,2019-07-09] -  Efficient exogenous DNA-free reprogramming with suicide gene vectors[EXPERIMENTAL AND MOLECULAR MEDICINE,2019-07-19] -  Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson's Disease Patients[INTERNATIONAL JOURNAL OF STEM CELLS,2019-11-30] -  Improvement of spinal muscular atrophy via correction of the SMN2 splicing defect by Brucea javanica (L.) Merr. extract and Bruceine D[PHYTOMEDICINE,2019-09-16] -  Mass cytometry-based single-cell analysis of human stem cell reprogramming uncovers differential regulation of specific pluripotency markers[Journal of Biological Chemistry,2019-09-30] -  Blood vessel formation in cerebral organoids formed from human embryonic stem cells[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020-01-01] -  Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions[TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2020-02-01] -  Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways[THERANOSTICS,2020-04-06] -  Maturation of human intestinal organoids in vitro facilitates colonization by commensal lactobacilli by reinforcing the mucus layer[FASEB JOURNAL,2020-06-30] -  Iroquois homeobox protein 2 identified as a potential biomarker for Parkinson’s disease[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020-05-14] -  Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes[JOURNAL OF CLINICAL MEDICINE,2020-06-16] -  Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease[MOLECULES,2020-08-07] -  Detection and Assessment of a-Synuclein Oligomers in the Urine of Parkinson’s Disease Patients[JOURNAL OF PARKINSONS DISEASE,2020-07-28] -  Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease[FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020-10-28] -  The combination of forskolin and VPA increases gene expression efficiency to the hypoxia/neuron-specific system[ANNALS OF TRANSLATIONAL MEDICINE,2020-08-01] -  CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual[Communications Biology,2020-01-20]

특허(최근 5년)

-  직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법[2017-01-10] -  세포 스페로이드 배양기를 포함하는 세포 스페로이드 배양 시스템[2017-05-29] -  인공 장 및 그 제조 방법[2018-04-11] -  OCT4 저해용 조성물 및 이의 용도[2019-02-08] -  자살유전자를 포함한 에피솜 벡터 및 이를 이용한 리프로그래밍 방법[2019-03-06] -  Reprogramming of cells to a new fate [2016-06-28] -  Reprogramming of cells to a new fate[2017-01-31] -  Method for preparation of induced dopaminergic progenitors using direct reprogramming [2019-03-12] -  In vitro에서 성숙된 인간 장관 오가노이드의 제조 방법 및 이의 용도[2019-09-23] -  3차원 장관 오가노이드 및 3차원 신경외배엽 구체를 포함하는 다장기 파킨슨병 모델 및 이의 용도[2020-03-04] -  세포 리프로그래밍 조성물 및 이를 이용한 유도만능줄기세포의 제조방법[2020-09-16]