박기덕 교수

Ki Duk Park

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
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연구분야

뇌질환 치료제 개발 및 작용기작에 관한 연구

Drug discovery for neurological diseases and identification of drug mechanisms

대표연구실적

-  박종현, 주연하 최지원, 송효정, 장보고, 우준성, 전희정, 김현정, 신수정, Yarishkin O., 조선미, 박미정, 연슬기, 김시원, 김정연, 남민호, Londhe A. M., 김지나, 조성진, 조승목, 이창호, 황성연, 김상욱, 오수진, 조제원, 배애님, 이창준, 박기덕/ Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease/ Science Advances/ 2019 -  최지원, 김시원, 박종현, 김현정, 신수정, 김진우, 우서연, 이창호, 이재익, 배애님, 한균희, 박기덕/.* Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson’s disease therapy/ Journal of Medicinal Chemistry/ 2019/ 62/r’s disease/ Science Advances/ 2019 -  김현정, 장보고, 박종현, 최지원, 박선준, 변성림, 배애님, 이용섭, 정은지, 박기덕/ A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model./ European Journal of Medicinal Chemistry./ 2020

논문(최근 5년)

-  Relationship between chromatographic resolution and amide structure of chiral 2-hydroxy acids as O-(?)-menthoxycarbonylated diastereomeric derivatives for enantiomeric separation on achiral gas chromatography[Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,2016-02-15] -  Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica[CHEMMEDCHEM,2016-01-25] -  Glycyrrhizic acid prevents astrocyte death by neuromyelitis optica-specific IgG via inhibition of C1q binding[Biochemical and biophysical research communications,2016-09-16] -  (S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology[Pain,2016-07-01] -  Efficacy of (S)-lacosamide in preclinical models of cephalic pain[pain reports,2016-05-21] -  Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-05] -  Hydroxycholesterol levels in the serum and cerebrospinal fluid of patients with neuromyelitis optica revealed by LC-Ag+CIS/MS/MS and LC-ESI/MS/MS with picolinic derivatization: Increased levels and association with disablility during acute attack[PLOS ONE,2016-12-12] -  α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors[ MOLECULAR PHARMACOLOGY,2016-11-01] -  Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-01] -  Novel scaffold identification of mGlu1 receptor negative allosteric modulators using a hierarchical virtual screening approach[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-02-15] -  Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-06-01] -  A novel synthetic isothiocyanate ITC-57 displays antioxidant, anti-inflammatory, and neuroprotective properties in a mouse Parkinson’s disease model[FREE RADICAL RESEARCH,2016-09-01] -  Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B Inhibitors toward Parkinson’s disease therapy[Bioorganic & medicinal chemistry,2018-01-01] -  Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220[Neurochemistry international,2018-01-01] -  CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1 (NF1)-related pain that is reversed by (S)-Lacosamide[Pain,2017-12-01] -  Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity[European journal of medicinal chemistry,2017-12-01] -  CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation[MOLECULAR NEUROBIOLOGY,2018-05-01] -  Mammalian target of rapamycin complex I and its downstream effector collapsing response mediator protein-2 drive reinstatement of alcohol reward seeking[ADDICTION BIOLOGY,2018-07-18] -  Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB2R affinity[BIOORGANIC & MEDICINAL CHEMISTRY,2018-10-01] -  The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2[EXPERIMENTAL NEUROBIOLOGY,2018-10-01] -  First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl)amino)pyrimidin-5-yl)benzamide as a potential anti-tauopathies agent[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2019-01-15] -  Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson’s disease therapy[JOURNAL OF MEDICINAL CHEMISTRY,2018-12-12] -  Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease[SCIENCE ADVANCES,2019-03-01] -  Activation of Astrocytic mu-opioid receptor causes conditioned place preference[CELL REPORTS,2019-07-01] -  Phosphorylated CRMP2 regulates spinal nociceptive neurotransmission[MOLECULAR NEUROBIOLOGY,2019-07-01] -  Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy[PAIN,2019-07-01] -  Antioxidant, anti-inflammatory, and neuroprotective effects of novel vinyl sulfonate compounds as Nrf2 activator[ACS MEDICINAL CHEMISTRY LETTERS,2019-06-03]

특허(최근 5년)

-  mGluR5의 표식용 방사성 조성물[2015-12-16] -  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  칼콘 유도체 화합물, 이의 광학이성질체, 또는 이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 포함하는 미토콘드리아의 산소 소모율 감소에 의해 야기되는 질환의 예방 또는 치료용 약학 조성물[2018-04-30] -  글리시리직애씨드 및 이의 용도[2019-01-04] -  대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 이소옥사졸 유도체[2016-09-30] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2016-10-05] -  4-이소프로필크로만-3-올 화합물[2016-11-18] -  알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물[2016-11-21] -  5-HT7 수용체에 작용하는 바이페닐 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 약학조성물[2017-11-02] -  벤조옥사졸 또는 벤조티아졸 화합물, 그의 제조, 및 용도[2017-02-17] -  Nrf2 활성화 효능의 세스퀴터핀 화합물 및 이를 유효성분으로 포함하는 약학조성물[2017-02-24] -  시신경 척수염 예방 또는 치료용 피리미딘 카복실레이트 유도체[2017-03-06] -  비닐 설폰 유도체, 이의 약학적으로 허용가능한 염 및 이을 유효성분으로 포함하는 시신경 척추염 예방 또는 치료용 약학조성물[2017-03-21] -  외상성 자극에 반응하는 타우 응집 세포주[2017-03-27] -  전이성 타우 단백질 및 이의 제조 방법[2017-03-29] -  티올 반응성 로사민 유도체 및 그의 용도[2017-04-03] -  항비만 치료용 가역적 마오비 저해제[2017-06-05] -  아크릴로니트릴 화합물 및 이를 포함하는 약학 조성물[2017-10-27] -  척수 손상의 예방 및 치료용 조성물[2019-04-11] -  뇌졸중의 예방 및 치료용 조성물[2019-07-23] -  Alpha-aminoamide derivative compound and pharmaceutical composition containing the same [2018-10-04]