이준석 교수

Lee, Jun-Seok

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5092
  • 출신전공Bioorganic Chemistry
  • 학위박사
  • 최종출신대학New York Univ
  • 이메일
개인홈페이지

연구분야

화학생물학, 조합화학, 분자인지, 분자진화

chemical biology, combinatorial chemistry, molecular recognition, molecular evolution

대표연구실적

-  Bulk aggregation based fluorescence turn-on sensors for selective detection of progesterone in aqueous solution. Hong, S. C.; Murale, D. P.; Lee, M.; Lee, S. M.; Park, J. S.; Lee, J. S.* Angew. Chem. Int. Ed., 2017, 56, 14642 ?14647. -  Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe. Hong, S. C.; Murale, D. P.; Jang, S. Y.; Haque, M. M.; Seo, M.; Lee, S.; Woo, D. H.; Kwon,J.; Song, C. S.; Kim, Y. K.; Lee, J. S.* Angew. Chem. Int. Ed., 2018, 57, 9716-9721. -  A vinyl sulfone-based fluorogenic probe capable of selective labeling of PHGDH in live mammalian cells. Pan, S.; Jang, S. Y.; Liew, S. S.; Fu, J.; Wang, D.; Lee, J. S.*; Yao, S. Q.* Angew. Chem. Int. Ed., 2018, 57, 579-583.

논문(최근 5년)

-  In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors[Chemistry : a European journal,2016-04-26] -  Combinatorial Dansyl Library and its Applications to pH-Responsive Probes[Combinatorial chemistry & high throughput screening,2016-05-01] -  Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications [Angewandte Chemie international edition,2016-02-01] -  A Suite of “Minimalist” Photo-Crosslinkers for Live-Cell Imaging and Chemical Proteomics: Case Study with BRD4 Inhibitors[Angewandte Chemie international edition,2017-08-01] -  A chemoselective cleavable fluorescence turn-ON linker for proteomic studies[Chemical communications,2017-11-24] -  A Novel Computational Method for Biomedical Binary Data Analysis: Development of a Thyroid Disease Index Using a Brute-Force Search with MLR Analysis[Bulletin of the Korean Chemical Society,2017-10-27] -  A Vinyl Sulfone-Based Fluorogenic Probe Capable of Selective Labeling of PHGDH in Live Mammalian Cells[Angewandte Chemie international edition,2017-12-07] -  Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker[Angewandte Chemie international edition,2017-10-23] -  Bulk Aggregation Based Fluorescence Turn-On Sensors for Selective Detection of Progesterone in Aqueous Solution[Angewandte Chemie international edition,2017-10-23] -  Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker[ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018-02-14] -  Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile To Form Light-Responsive Vesicles[ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018-02-01] -  Chloro-Functionalized Photo-crosslinking BODIPY for Glutathione Sensing and Subcellular Trafficking[CHEMBIOCHEM,2018-04-23] -  Discrimination of Avian Influenza Virus Subtypes using Host-Cell Infection Fingerprinting by a Sulfinate-based Fluorescence Superoxide Probe[ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018-07-01] -  Reinvestigation of an O­Salicylaldehyde Ester Functional Group in Aqueous Buffer and Discovery of a Coumarin Scaffold Probe for Selective N­-Terminal Cysteine Labeling[CHEMBIOCHEM,2018-11-13] -  Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes[CHEMICAL COMMUNICATIONS,2018-12-21] -  Differentiation of selectively labeled peptides using solid-state nanopores[NANOSCALE,2019-01-01] -  Expanding the “minimalist” small molecule tagging approach to different bioactive compounds[ORGANIC & BIOMOLECULAR CHEMISTRY,2019-02-11] -  Crosstalk between Oxidative Stress and Tauopathy[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019-04-01] -  Recent Developments in Metal-Catalyzed Bio-orthogonal Reactions for Biomolecule Tagging[CHEMBIOCHEM,2019-04-15] -  A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2[JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019-08-22] -  Nano metamaterials for ultrasensitive Terahertz biosensing[SCIENTIFIC REPORTS,2017-08-01] -  Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues[CHEMICAL COMMUNICATIONS,2017-07-05] -  Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)[PROTEOME SCIENCE,2017-06-01] -  Global Mapping of Protein-Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells[ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017-04-21]

특허(최근 5년)

-  단백질 표지를 위한 광가교성 기반의 HBT 유도체 [2017-11-21] -  BODIPY 유도체, 그 제조방법 및 이를 이용한 미토콘드리아 표지방법[2018-01-29] -  세포주 기반 AI 바이러스 검출 및 동정 시스템[2017-11-07] -  순환기계 시계열 의료 및 바이오데이터의 특성 패턴 생성 및 타이핑 방법[2017-12-08]