허우영 교수

Hur, Wooyoung

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5193
  • 출신전공화학
  • 학위박사
  • 최종출신대학The Scripps Research Institute
  • 이메일

연구분야

화학생물학

Chemical biology

대표연구실적

-  Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chemistry & Biology 2010 May 28 -  Zhou W*, Hur W* (공동 1저자), McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS. A structure-guided approach to creating covalent FGFR inhibitors. Chemistry & Biology 2010 Mar 26 -  Hur W, Gray NS. Small molecule modulators of antioxidant response pathway. Current Opinion Chemical Biology. 2011 Feb

논문(최근 5년)

-  A benzo[b]thiophene-based selective type 4 S1P receptor agonist[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-01-01] -  Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion[ BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2017-01-31] -  Identification of the first selective Activin receptor-Like Kinase 1 inhibitor, a reversible version of L-783277[ JOURNAL OF MEDICINAL CHEMISTRY,2017-01-19] -  Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors [ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-09-08] -  Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs[CHEMICAL BIOLOGY & DRUG DESIGN,2018-02-01] -  Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-09-05] -  Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018-12-15] -  First SAR study for overriding NRAS mutant driven acute myeloid leukemia[JOURNAL OF MEDICINAL CHEMISTRY,2018-08-27]

특허(최근 5년)

-  항암 활성을 갖는 신규 피리미딘-4-카르복시산 유도체(Novel Pyrimidine-4-Carboxylic Acid Derivatives Having Anti-tumor Activity)[2017-04-04] -  RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물(Novel 3-(isoxazol-3-yl)-pyrazolo[3,4-d]pyrimidin-4-amine compounds as RET kinase inhibitor)[2017-08-02] -  Heteroamine derivatives as protein kinase inhibitors[2017-03-07] -  1,3,7-삼치환된 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 유도체들의 급성골수성백혈병 치료 효능[2018-01-08] -  단백질 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 유도체들의 제조방법 및 약학적 활용[2017-12-19] -  AZD4547 신규 유도체[2018-01-15] -  단백질 키나아제 저해제인 신규 N-(3,5-디메톡시페닐)-1-(피리미딘-4-일)-1H-벤조[d]이미다졸-2-아민 유도체들의 제조방법 및 약학적 활용[2018-04-13] -  1,6-이치환된 인돌 화합물을 함유하는 약물 내성 및 부작용이 저감된 만성골수성백혈병 치료제[2018-04-26] -  단백질 키나아제 저해 활성을 갖는 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 골격의 유레아 화합물[2018-09-05] -  Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors[2018-08-28] -  CML therapeutic agents with reduced drug-resistance and side-effect comprising 1,6-disubstituted indole compounds[2018-11-20] -  Therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-D]pyrimidine-2(1H)-one derivatives[2018-12-18] -  항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는[2019-01-02] -  단백질 키나아제 저해제인 신규 2,3,5-치환된 싸이오펜 화합물[2019-03-28]