손미영 교수

MI-YOUNG SON

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4426
  • 출신전공생명과학과(협동과정)
  • 학위박사
  • 최종출신대학한국과학기술원
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연구분야

줄기세포 기반 3차원 오가노이드 연구 및 질환 모델링

Study of stem cell-based organoids & disease modeling

대표연구실적

-  Jung KB, Kwon O, Lee MO, Lee H, Son YS, Habib O, Oh JH, Cho HS, Jung CR, Kim J, Son MY. Blockade of STAT3 causes severe in vitro and in vivo maturation defects in intestinal organoids derived from human embryonic stem cells. Journal Clinical Medicine 2019 Jul 4;8(7). (Corresponding author) -  Lee MO, Jung KB, Jo SJ, Hyun SA, Moon KS, Seo JW, Kim SH, Son MY. Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. Journal of Biological Engineering 2019 Feb 13;13:15. (Corresponding author) -  Jung KB, Lee H, Son YS, Lee MO, Kim YD, Oh SJ, Kwon O, Cho S, Cho HS, Kim DS, Oh JH, Zilbauer M, Min JK, Jung CR, Kim JH, Son MY. Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids. Nature Communications 2018 Aug 2;9(1):3039. (Corresponding author)

저서(최근 5년)

-  Methods in Molecular Biology[2020-03-01]

논문(최근 5년)

-  Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles[ TOXICOLOGY AND APPLIED PHARMACOLOGY,2016-05-15] -  Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-05-13] -  Pro-fibrotic effects of PFKFB4-mediated glycolytic reprogramming in fibrous dysplasia[ BIOMATERIALS,2016-11-01] -  Biomarker discovery by modeling Behcet’s disease with patient specific human induced pluripotent stem cells[ STEM CELLS AND DEVELOPMENT,2017-01-15] -  Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells[NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,2017-12-01] -  The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN[ STEM CELL RESEARCH,2017-05-30] -  Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum[ MOLECULAR BIOSYSTEMS,2017-07-25] -  Clump-passaging-based efficient 3D culture of human pluripotent stem cells under chemically defined conditions[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-11-04] -  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models[ HEPATOLOGY,2017-11-01] -  In vitro and in vivo imaging and tracking of intestinal organoids from human-induced pluripotent stem cells[ FASEB JOURNAL,2018-01-01] -  Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC[ ONCOTARGET,2017-12-14] -  EHMT2 is a metastasis regulator in breast cancer[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018-02-05] -  Comparative analysis of human embryonic stem cell-derived neural stem cells as an in vitro human model[ INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018-02-01] -  Comparative in silico profiling of epigenetic modifiers in human tissues[MOLECULAR BIOLOGY REPORTS,2018-06-01] -  Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.[NATURE COMMUNICATIONS,2018-08-02] -  The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer[INTERNATIONAL JOURNAL OF ONCOLOGY,2019-01-01] -  SETDB1 regulates SMAD7 expression for breast cancer metastasis.[BMB REPORTS,2019-02-01] -  Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells[JOURNAL OF BIOLOGICAL ENGINEERING,2019-02-13] -  Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer[ONCOLOGY REPORTS,2019-03-06] -  Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity[JOURNAL OF BIOLOGICAL ENGINEERING,2019-03-06] -  A SMN2 splicing modifier rescues the disease phenotypes in an in vitro human spinal muscular atrophy model[STEM CELLS AND DEVELOPMENT,2019-04-01] -  Efficient exogenous DNA-free reprogramming with suicide gene embodied vectors[EXPERIMENTAL AND MOLECULAR MEDICINE,2019-07-19] -  Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer[MOLECULAR MEDICINE REPORTS,2019-08-01] -  Blockade of STAT3 causes severe in vitro and in vivo maturation defects in intestinal organoids derived from human embryonic stem cells[JOURNAL OF CLINICAL MEDICINE,2019-07-04] -  Direct reprogramming to human induced neuronal progenitors from fibroblasts of familial and sporadic Parkinson’s disease patients[INTERNATIONAL JOURNAL OF STEM CELLS,2019-08-31] -  Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids[JOURNAL OF HEPATOLOGY,2019-07-09] -  The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN[ STEM CELL RESEARCH,2017-05-30] -  Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC[ ONCOTARGET,2017-12-14] -  Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.[NATURE COMMUNICATIONS,2018-08-02] -  SETDB1 regulates SMAD7 expression for breast cancer metastasis.[BMB REPORTS,2019-02-01] -  A SMN2 splicing modifier rescues the disease phenotypes in an in vitro human spinal muscular atrophy model[STEM CELLS AND DEVELOPMENT,2019-04-01] -  Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids[JOURNAL OF HEPATOLOGY,2019-07-09] -  Efficient exogenous DNA-free reprogramming with suicide gene embodied vectors[EXPERIMENTAL AND MOLECULAR MEDICINE,2019-07-19] -  Blockade of STAT3 causes severe in vitro and in vivo maturation defects in intestinal organoids derived from human embryonic stem cells[JOURNAL OF CLINICAL MEDICINE,2019-07-04] -  Direct reprogramming to human induced neuronal progenitors from fibroblasts of familial and sporadic Parkinson’s disease patients[INTERNATIONAL JOURNAL OF STEM CELLS,2019-11-30] -  Mass cytometry-based single-cell analysis of human stem cell reprogramming uncovers differential regulation of specific pluripotency markers [JOURNAL OF BIOLOGICAL CHEMISTRY,2019-12-06] -  Ischemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor B[FASEB JOURNAL,2020-01-01] -  RNA-seq based transcriptome analysis of EHMT2 functions in breast cancer[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020-04-09] -  Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin[CELL DEATH & DISEASE,2020-04-14] -  Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways[THERANOSTICS,2020-04-06]

특허(최근 5년)

-  다능성 줄기세포의 제작, 유지, 증식을 증진하는 대사산물 및 이를 포함하는 조성물과 배양방법 [2016-09-05] -  뮤코지질증 인간 세포 모델 및 이의 용도[2017-10-02] -  세포 스페로이드 배양기를 포함하는 세포 스페로이드 배양 시스템[2017-05-29] -  GM1 강글리오시드증의 인간 세포 모델 및 이의 용도[2017-05-17] -  Diagnostic kit used for Behcet's disease comprising a means for determining the expression level of CXCL1[2017-03-29] -  베체트병의 인간 세포 모델 및 이의 용도[2016-11-24] -  조직 간 유사성 및 분화 수준에 대한 정보 제공 방법[2018-11-15] -  인공 장 및 그 제조 방법 [2018-04-11] -  자살유전자를 포함한 에피솜 벡터 및 이를 이용한 리프로그래밍 방법[2019-03-06] -  HUMAN CELL MODEL OF GM1 GANGLIOSIDOSIS AND USE OF SAME[2019-04-03] -  HUMAN CELL MODEL OF GM1 GANGLIOSIDOSIS AND USE OF SAME[2019-04-03] -  METHOD FOR TREATMENT OF GM1 GANGLIOSIDOSIS[2018-07-31] -  In vitro에서 성숙된 인간 장관 오가노이드의 제조 방법 및 이의 용도[2019-09-23] -  3차원 장관 오가노이드 및 3차원 신경외배엽 구체를 포함하는 다장기 파킨슨병 모델 및 이의 용도[2019-03-04]

연구과제 수행 실적

3차원 오가노이드 기술을 통한 인체 모방 기능성 장관모델 개발 혈관화된 3차원 생체조직 (간/심장, 암) 모사 칩 기반 약물 효능 및 독성 평가 시스템의 개발 인간 장관모델 기반 마이크로바이옴 연구 플랫폼 구축 및 활용기술 개발 생체적합성 기능성 박막 기반 표면개질 기술을 통한 임상용 장질환 및 심장질환 줄기세포 치료제 생산 원천기술 개발