박종국 교수

JONG KUK, PARK

INFO

  • 소속캠퍼스한국원자력의학원
  • 전공 방사선종양의과학
  • 연락처02-970-1321
  • 출신전공분자세포생물학
  • 학위박사
  • 최종출신대학서강대학교
  • 이메일

연구분야

방사선 이용 암치료 효율 증대 연구

Investigation of Effectiveness Improvement of Radiatio-therapy against Cancer

대표연구실적

-  박종국 외 6인/Luteolin acts as a radiosensitizer in non small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade/Int J Oncol/2015 -  박종국 외 6인/Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway/Biomedicine & Pharmacotherapy/2015 -  박종국외 7인/ICAM-3 endows anticancer drug resistance against microtubule-damaging agents via activation of the ICAM-3-AKT/ERK-CREB-2 pathway and blockage of apoptosis/Biochem Biophys Res Commun/2013

논문(최근 5년)

-  Src and epidermal growth factor receptor mediate the pro-invasive activity of Bcl-w[ TUMOR BIOLOGY,2016-06-01] -  Gamma-Ionizing radiation-induced activation of the EGFR-p38/ERK-STAT3/CREB-1-EMT pathway promotes the migration /invasion of non-small cell lung cancer cells and is inhibited by podpphyllotoxin acetate[ TUMOR BIOLOGY,2015-12-15] -  Chemosensitizing effect of podophyllotoxin acetate on topoisomerase inhibitors leads to synergistic enhancement of lung cancer cell apoptosis [ INTERNATIONAL JOURNAL OF ONCOLOGY,2016-06-01] -  Involvement of SULF2 in gamma-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression[ ONCOTARGET,2016-02-17] -  The p53/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins[ CANCER RESEARCH,2017-04-04]

특허(최근 5년)

-  포도필로톡신 아세테이트를 유효성분으로 포함하는 방사선 치료 증진제[2015-12-15] -  항암제 내성 예측용 바이오마커로서의 ICAM-3 및 이의 용도[2016-11-04] -  Bax/complex-1 복합체를 이용한 암전이 억제제의 스크리닝 방법[2016-03-24] -  p21의 c-말단 영역을 이용한 암전이 억제제의 스크리닝 방법[2016-05-02] -  방사선 내성 암치료용 약학 조성물[2017-08-23]