오경진 교수

Kyoung-Jin Oh

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8265
  • 출신전공분자세포생물학
  • 학위박사
  • 최종출신대학성균관대학교 자연과학캠퍼스
  • 이메일

연구분야

제 2형 당뇨 및 비만에서 인슐린 신호전달체계와 에너지 대사 규명 및 제어 연구

Glucose/lipid metabolism and insulin resistance in type 2 diabetes and obesity

대표연구실적

-  Dongryeol Ryu*, Kyoung-Jin Oh*, Hee-Yeon Jo, Susan Hedrick, Yo-Na Kim, Yu-Jin Hwang, Tae-Sik Park, Joong-Soo Han, Cheol Soo Choi, Marc Montminy and Seung-Hoi Koo. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metabolism. 2009 Mar;9(3):240-251. (*Co-first authors) -  Dahee Choi*, Kyoung-Jin Oh*, Hye Sook Han, Young-Sil Yoon, Sang-Yoon Choi, Seong-Tae Kim and Seung-Hoi Koo. Protein arginine methyltransferase-1 regulates hepatic glucose production in a FoxO1 dependent manner. Hepatology. 2012 Oct;56 (4):1546-56. (*Co-first authors) -  Kyoung-Jin Oh, Jinyoung Park, Su Sung Kim, Hyunhee Oh, Cheol Soo Choi and Seung-Hoi Koo. TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver. PLoS Genet. 2012 Sep;8(9): e1002986.

논문(최근 5년)

-  Profiling analysis of protein tyrosine phosphatases during neuronal differentiation.[ NEUROSCIENCE LETTERS,2016-01-26] -  Insulin-inducible SMILE inhibits hepatic gluconeogenesis. [ DIABETES,2016-01-01] -  c-Jun regulates adipocyte differentiation via the KLF15-mediated mode. [ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-01-15] -  Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM2, a subunit of ESCRT-0. [PLOS ONE,2016-02-11] -  Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation.[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-08-15] -  Small molecules facilitate single factor-mediated hepatic reprogramming[Cell Reports,2016-04-26] -  Methyltransferase and demethylase profiling studies during brown adipocyte differentiation.[BMB REPORTS,2016-05-09] -  Effect of BI-1 on insulin resistance through regulation of CYP2E1. [SCIENTIFIC REPORTS,2016-08-31] -  Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016-12-22] -  Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase. [ARCHIVES OF VIROLOGY,2017-11-01] -  HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription.[MOLECULES AND CELLS,2017-09-30] -  Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation. [NATURE COMMUNICATIONS,2018-08-24] -  Protein Tyrosine Phosphatase, Receptor Type B (PTPRB) Inhibits Brown Adipocyte Differentiation through Regulation of VEGFR2 Phosphorylation.[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2019-04-28] -  Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs.[Journal of Clinical Medicine,2019-06-14] -  The Latest Insights into Adipokines in Diabetes[Journal of Clinical Medicine,2019-11-05] -  Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes.[CELL DEATH & DISEASE,2019-11-04] -  The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases[International Journal of Molecular Sciences,2019-10-04] -  Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.[AUTOPHAGY,2020-01-02] -  Rapid differentiation of astrocytes from human embryonic stem cells[Neuroscience Letters,2020-01-18] -  Roles of Protein Histidine Phosphatase 1 (PHPT1) in Brown Adipocyte Differentiation[Journal of Microbiology and Biotechnology,2020-02-28] -  IDH1-dependent α-KG regulates brown fat differentiation and function by modulating histone methylation[Metabolism: Clinical and Experimental,2020-04-01] -  Nurr1 performs its anti?inflammatory function by regulating RasGRP1 expression in neuro?inflammation[Scientific Reports,2020-07-01] -  GATA3 induces the upregulation of UCP-1 by directly binding to[Metabolism: Clinical and Experimental,2020-08-01] -  The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene[Journal of Biological Chemistry,2020-08-03]

특허(최근 5년)

-  지각 추출물 및 콜레우스 포스콜리 추출물을 유효성분으로 함유하는 비만 예방 또는 개선용 건강기능식품[2018-10-17] -  TCF7L2를 유효성분으로 함유하는 비알코올성 지방간의 예방 또는 치료용 약학 조성물(Pharmaceutical composition for prevention and treatment of non-alcoholic fatty liver disease comprising transcription factor 7-like 2 as effective component)[2019-09-03]

연구과제 수행 실적

근육과 간에서의 당뇨 유전자 TCF7L2의 역할 규명 대사네트워크 규명을 통한 대사질환제어 기술개발 생체 에너지대사 조절을 통한 난치성 대사질환 제어기술 개발 AI 기반 비알콜성 지방간(NAFL)/지방간염(NASH) 치료물질 발굴 비알콜성 지방간/지방간염(NAFL/NASH) 유래 간암(HCC) 제어타겟 발굴