이무승 교수

Lee, Moo-Seung

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처042-879-8292
  • 출신전공미생물분자병리 및 면역학
  • 학위박사
  • 최종출신대학Texas A&M University
  • 이메일

연구분야

세포생물학기반의 감염성병인자 단백질과 숙주세포간의 상호작용, 세포내 분자병리면역기전 및 감염원 대응 백신개발

Microbial infectious agents and host cells interaction. Microbial molecular pathogenesis and medical immunology. Vaccine and therapeutic protein development

대표연구실적

-  이무승(교신저자)외 1명/Roles of Shiga toxins in Immunopathology/Toxins/2019 -  이무승(주저자)외7명/Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death/Infection and Immunity/2016 -  이무승(공동저자)/Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome/Nature Communications/2015

논문(최근 5년)

-  Shiga Toxins as multi-functional proteins:induction of host cellular stress responses, role in pathogenesis and therapeutic applications[TOXINS,2016-03-17] -  Shiga toxins activate the NLRP3 inflammasome pathway to promote both production of the proinflammatory cytokine interleukin-1betta and apoptotic cell death[INFECTION AND IMMUNITY,2016-01-01] -  Shiga toxins trigger the secretion of lysyl-tRNA synthetase to enhance proinflammatory responses[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2016-02-28] -  Complete mitochondrial genome of the invasive semi-aquatic mammal, nutria Myocastor coypus (Rodentia; Myocastoridae)[CONSERVATION GENETICS RESOURCES,2017-09-27] -  Optimized Expression, Purification, and Rapid Detection of Recombinant Influenza Nucleoproteins Expressed in Sf9 Insect Cells [JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2018-10-28] -  Complete Genome Sequence of Aeromonas rivipollensis KN-Mc-11N1,Isolated from a Wild Nutria (Myocastor coypus) in South Korea [Genome Announcements,2018-08-02] -  Experimental In Vivo Models of Bacterial Shiga Toxin-Associated Hemolytic Uremic Syndrome[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2018-09-28] -  Structural and physiological exploration of Salmonella Typhi YfdX uncovers its dual function in bacterial antibiotics stress and virulence[FRONTIERS IN MICROBIOLOGY,2019-01-14] -  Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells [TOXINS,2017-10-13] -  Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ[JOURNAL OF ENDOCRINOLOGY,2017-12-01] -  Simultaneous detection of severe acute respiratory syndrome,Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR[ARCHIVES OF VIROLOGY,2017-02-20] -  Nucleotide-Binding Oligomerization Domain 2 Contributes to Limiting Growth of Mycobacterium abscessus in the Lung of Mice by Regulating Cytokines and Nitric Oxide Production[FRONTIERS IN IMMUNOLOGY,2017-11-06] -  Complete genome sequence of multidrug-resistant Staphylococcus cohnii ssp. urealyticus strain SNUDS-2 isolated from farmed duck, Republic of Korea.[JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,2017-09-01] -  Complete genome sequence of multidrug-resistant Staphylococcus sciuri strain SNUDS-18 isolated from a farmed duck in South Korea.[JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,2017-12-01] -  Production of recombinant human procollagen type I C-terminal propeptide and establishment of a sandwich ELISA for quantification.[SCIENTIFIC REPORTS,2017-11-21] -  Roles of Shiga Toxins in Immunopathology[TOXINS,2019-04-09] -  Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages.[JOURNAL OF INNATE IMMUNITY,2019-03-07] -  Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea [MICROORGANISMS,2019-07-30] -  Thioredoxin-interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome Mediated Caspase-1 Activation in Macrophages[FRONTIERS IN IMMUNOLOGY,2019-11-12] -  Increased O-GlcNAcylation of c-Myc promotes Pre-B cell proliferation[CELLS,2020-01-08] -  IL-10 Protects Mice From the Lung Infection of Acinetobacter baumannii and Contributes to Bacterial Clearance by Regulating STAT3-Mediated MARCO Expression in Macrophages[FRONTIERS IN IMMUNOLOGY,2020-02-21] -  Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin[CELL DEATH & DISEASE,2020-04-14] -  Recent updates on outbreaks of shiga toxin-producing Escherichia coli and its potential reservoirs[FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2020-06-04] -  A portable and high-sensitivity optical sensing system for detecting fluorescently labeled enterohaemorrhagic Escherichia coli Shiga toxin 2B-subunit[PLOS ONE,2020-07-16] -  Exosomes released from Shiga toxin 2a-treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells[CELLULAR MICROBIOLOGY,2020-09-06]

특허(최근 5년)

-  장출혈성대장균 유래의 시가독소 타입 1 B-subunit으로 유도된 노인성 황반변성(AMD) 동물모델 및 이를 이용한 스크리닝 방법[2019-06-04]

연구과제 수행 실적

인플루엔자 바이러스 신속 진단을 위한 항원 개발 메르스 백신 개발을 위한 면역항원 발굴 연구 비독성 시가독소B서브유닛전달체와 항균펩타이드 LL-37 결합체를 통한 다제내성 Acinetobacter baumannii 감염대식세포/수지상세포 동시표적능향상 및 치료선도물질도출 용혈성요독증후군(HUS) 유발 장출혈성대장균 시가독소 신규 제어기술 연구 바이러스조기진단을 위한 진핵세포발현시스템 기반 재조합항원 개발 및 항원개발 시스템의 구축 해양바이오소재를 활용한 화장품원료개발