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bang jeong kyu

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  • 소속캠퍼스한국기초과학지원연구원
  • 전공 생물분석과학
  • 직급전공책임교수
  • 연락처043 240 5023
  • 출신전공생유기화학
  • 학위박사
  • 최종출신대학Osaka University
  • 이메일

연구분야

생유기화학

Bioorganic chemistry

대표연구실적

-  Mija Ahn, Young-Hyun Han, Jung-Eun Park, Jeong Kyu Bang/A New Class of Peptidomimetics Targeting the Polo-box domain of Polo-Like Kinase 1/Journal of Medicinal Chemistry/2014년10월27일 -  jia-Lin Jia, Young-Hyun Han, Jeong Kyu Bang, Nam-Hyung Kim, Suk namgoong/Structural basis for recognition of EMi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization/Scientific Report/2015월10월13일 -  Ganipisetti Srinivasrao, Jeong Kyu Bang/Design and Synthesis of a cell-permeable, Drug-like Small molecule inhibitor targeting the polo-box domain of polo-like kinase 1/PLoS ONE/2014년9월11일

논문(최근 5년)

-  Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity[Amino Acids,2014-06-25] -  Enhancement of Antibacterial Activity of Short Tryptophan-rich Antimicrobial Peptide Pac-525 by Replacing Trp with His(chx)[Bull.Korean Chemical Soc.,2014-05-30] -  Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis[Nature structural and molecular biology,2014-06-29] -  Enhanced cellular uptake of a TAT?conjugated peptide inhibitor targeting the polo?box domain of polo?like kinase 1[Amino Acids,2014-08-24] -  Design and Synthesis of a Cell-Permeable Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1[PLoS ONE,2014-09-11] -  Multi-Frequency Multi-Technique Pulsed EPR Investigation of the Copper Binding Site of Murine Amyloid b Peptide[Angew.chem.Int.Ed,2015-01-26] -  Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4[Biochemical and Biophysical research Commumications,2015-08-21] -  Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity[Biochemistry,2015-06-08] -  Mammalian Polo-like Kinase 1 (Plk1) Promotes Proper Chromosome Segregation by Phosphorylating and Delocalizing the PBIP1 CENP-Q Complex from Kinetochores[Journal of biological Chemistry,2015-02-10] -  A New Class of Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1[Journal of Medicinal Chemistry,2014-10-27] -  Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold Cep192 in the Regulation of Bipolar Spindle Formation[molecular and cellular biology,2015-05-26] -  Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilizatio[Scientific Report,2015-10-13] -  The stereochemical effect of SMAP-18 on bacterial selectivty, membrane interaction and anti-inflammatory activiy[AMINO ACIDS,2016-01-21] -  Effect of antifreeze glycoprotein 8 suplementaion during vitrification on the develiopmental competence of bovine oocytes[THERIOGENOLOGY,2016-01-30] -  Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-09-23] -  Effects of antifreeze glycoprotein 8 (AFGP8) supplementation during vitrification on the in vitro developmental capacity of expanded bovine blastocysts[REPRODUCTION FERTILITY AND DEVELOPMENT,2017-01-19] -  Pyrrole-Based, Macrocyclic, Small-Molecule Inhibitors Targeting Oocyte Maturation[CHEMMEDCHEM,2017-03-13] -  Investigation of cationicity and structure of pseudin-2 analogues for enhanced bacterial selectivity and anti-inflammatory activity[SCIENTIFIC REPORTS,2017-03-28] -  Structure-dependent antimicrobial theranostic functions of self-assembled short-peptide nanoagents[BIOMACROMOLECULES,2017-08-24] -  Myxinidin 2and myxinidin 3 suppress inflammatory responses through STAT3 and MAPKs to promote wond healing[Oncotarget,2017-09-15] -  Structure-activity relationships of 6-and 8- Gingerol analogues as anti-biofilm agents[JOURNAL OF MEDICINAL CHEMISTRY,2017-11-14] -  Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-10-30] -  Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa[SCIENTIFIC REPORTS,2018-01-29] -  Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria[SCIENTIFIC REPORTS,2017-11-29] -  Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions[JOURNAL OF BIOLOGICAL CHEMISTRY,2018-01-24]

특허(최근 5년)

-  항균활성 및 항염증활성을 갖는 신규한 펩티드[2014-03-28]

연구과제 수행 실적

NBIT 융합기술 기반 생체 인산화 신호 체계 제어 연구(인산화효소 단백질 상호작용 분석) 단백질구조연구팀 운영 에피프로테옴 기반 발암·전이 저해제 개발 및 영상 이미징을 이용한 효능 검증 파킨슨 질환표적 단백질 동역학 연구 에피프로테옴기반 저독성 항암 치료기술 개발