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이영호 교수

LEE, Young-Ho

INFO

  • 소속캠퍼스한국기초과학지원연구원
  • 전공 생물분석과학
  • 연락처043-240-5071
  • 출신전공Macromolecular Science
  • 학위박사
  • 최종출신대학Osaka University
  • 이메일

연구분야

기능성 생체분자간 상호작용과 질병유발성 단백질 응집에 관한 연구

Study on the functional biomolecular interaction and disease-causing protein aggregation

대표연구실적

-  Kinoshita M., Lin Y., Dai I., Okumura M., Markova N., Ladbury J.E., Sterpone F. and Lee Y.-H. / Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry / Chem. Commun. / 2018 Jul 12 -  Ikenoue T.*, Lee Y.-H.*, Kardos J., Saiki M., Yagi H., Kawata Y. and Goto Y. / Cold Denaturation of Alpha-Synuclein Amyloid Fibrils / Angewandte chemie / 2014 Jun 11 (*equal contribution) -  Ikenoue T.*, Lee Y.-H.*, Kardos J., Yagi H., Ikegami T, Naiki H. and Goto Y. Heat of Supersaturation-limited Amyloid Burst Directly Monitored by Isothermal Titration Calorimetry / Proc. Natl. Acad. Sci. USA. / 2014 April 21 (*equal contribution)

논문(최근 5년)

-  Energy landscape of polymorphic amyloid generation of b2-microglobulin revealed by calorimetry[CHEMICAL COMMUNICATIONS,2018-07-12] -  BeStSel: a webserver for accurate protein secondary structure prediction and fold recognition from circular dichroism spectra[NUCLEIC ACIDS RESEARCH,2018-05-22] -  Structural basis of correct subunit assembly, aggregation, and intracellular degradation of the precursor protein[SCIENTIFIC REPORTS,2018-06-27] -  Graphene quantum dots prevent alpha-synuclein transmission in Parkinson's disease[NATURE NANOTECHNOLOGY,2018-07-09] -  Impact of membrane curvature on amyloid aggregation[BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2018-04-25] -  Semen-derived amyloidogenic peptides-Key players of HIV infection[PROTEIN SCIENCE,2018-02-26] -  Membrane-induced initial structure of alpha-synuclein control its amyloidgenesis on model membranes [BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2017-12-14] -  Model membrane size-dependent amyloidogenesis of Alzheimer's Amyloid-b peptides[PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2017-05-25] -  Kinetics and polymorphs of yeast prion sup35NM amyloidogenesis[INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017-05-01] -  Mechanistic and structural basis of bioengineered bovine cathelicidin-5 with optimized therapeutic activity[SCIENTIFIC REPORTS,2017-03-21] -  Reduced lipid bilayer thickness regulates the aggregation and cytotoxicity of amyloid-b[JOURNAL OF BIOLOGICAL CHEMISTRY,2017-05-17] -  Energetic basis on interactions between ferredoxin and ferredoxin NADP+ reductase at varying physiological conditions[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-11-25] -  Noncovalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity[BIOCHEMICAL JOURNAL,2016-08-22] -  Solution NMR structure and inhibitory effect against amyloid-b fibrillation of humanin containing a d-isomerized serine residue[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-06-23] -  Mutations affecting the internal equilibrium of the 6-aminohexano-atedimer hydrolase reaction[FEBS LETTERS,2016-08-04] -  A thiirane linker for isopeptide mimetics by peptide ligation[TETRAHEDRON LETTERS,2016-04-05] -  Amorphous aggregation of cytochrome c with inherently low amyloidogenicity is characterized by the metastability of supersaturation and the phase diagram[LANGMUIR,2016-01-29] -  X-ray structure and nuclear magnetic resonance analysis of the interaction sites of the Ga-substituted cyanobacterial ferredoxin[BIOCHEMISTRY,2015-09-08] -  Effects of a reduced disulfide bond on aggregation properties of the human IgG1 CH3 domain[BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS,2015-02-26] -  Physicochemical nature of interfaces controlling ferredoxin NADP+ reductase activity through its interprotein interactions with ferredoxin[BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS,2015-05-29] -  Optimized co-solute paramagnetic relaxation enhancement for the rapid NMR analysis of a highly fibrillogenic peptide[JOURNAL OF BIOMOLECULAR NMR,2015-06-01] -  Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015-06-02] -  Ultrasonication-dependent formation and degradation of alpha-synuclein amyloid fibrils[BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS,2014-12-12] -  Small liposomes accelerate the fibrillation of amyloid beta (1-40)[JOURNAL OF BIOLOGICAL CHEMISTRY,2014-11-18] -  Supersaturation-limited amyloid fibrillation of insulin revealed by ultrasonication[JOURNAL OF BIOLOGICAL CHEMISTRY,2014-06-27] -  Cold denaturation of alpha-synuclein amyloid fibrils[ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014-07-21] -  Heat-induced irreversible denaturation of the camelid single domain VHH antibody is governed by chemical modifications[JOURNAL OF BIOLOGICAL CHEMISTRY,2014-05-30] -  NMR characterization of the interaction of the endonuclease domain of MutL with divalent metal ions and ATP[PLOS ONE,2014-06-05] -  Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry[PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014-05-06]