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류경석 교수

Kyoung-Seok, Ryu

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  • 소속캠퍼스한국기초과학지원연구원
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연구분야

단백질 구조 및 동역학 연구

Protein structure and dynamics

대표연구실적

-  Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogs reveal distinct mechanisms for ligand recognition. JACS 2013. -  Probing the rate limiting step for intramolecular transfer of a transcription factor between specific sites on the same DNA molecule by 15Nz-exchange NMR spectroscopy. JACS 2014. -  Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 distinguishes their K48-ubiquitylation activities. JBC 2015.

논문(최근 5년)

-  Structural alteration of Escherichia coli Hsp31 by thermal unfolding increases chaperone activity. [Biochim Biophys Acta,2013-02-01] -  Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain.[J Mol Cell Biol. ,2013-02-03] -  Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogs reveal distinct mechanisms for ligand recognition. [J. Am. Chem. Soc. ,2013-09-18] -  Structural and dynamic features of cold-shock proteins of Listeria monocytogenes, a psychrophilic bacterium.[Biochemistry,2013-03-18] -  Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein[J Biomol NMR,2014-01-17] -  An Unusual Protein-Protein Interaction through Coupled Unfolding and Binding[Angew Chem Int Ed Engl,2014-09-08] -  Probing the rate limiting step for intramolecular transfer of a transcription factor between specific sites on the same DNA molecule by 15Nz-exchange NMR spectroscopy[J. Am. Chem. Soc. ,2014-09-25] -  Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithioacetalcontaining crystal structures[Febs J.,2014-10-04] -  Amphiphilic Peptide Nanorods Based on Oligo-Phenylalanine as a Biocompatible Drug Carrier[ BIOCONJUGATE CHEMISTRY,2017-06-25] -  Increasing the soluble expression and crystallization of the Escherichia coli quorum-sensing protein LsrK[ ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,2017-05-01] -  C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution[FEBS Letters,2017-02-28] -  Backbone resonance assignments of the Escherichia coli 62 kDa protein, Hsp31[ BIOMOLECULAR NMR ASSIGNMENTS,2017-03-03] -  The role of the KRSIK motif of human angiogenin in heparin and DNA binding[ RSC ADVANCES,2016-08-01] -  NMR study of the antifreeze activities of active and inactive isoforms of a type III antifreeze protein[FEBS Letters,2016-12-01] -  Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition[ NUCLEIC ACIDS RESEARCH,2016-01-20] -  Semi-Empirical Structure Determination of Escherichia coli Hsp33 and Identification of Dynamic Regulatory Elements for the Activation Process[ JOURNAL OF MOLECULAR BIOLOGY,2015-10-07] -  Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression[ NUCLEIC ACIDS RESEARCH,2016-12-01] -  Structural Convergence of Unstructured p53 Family Transactivation Domains in MDM2 Recognition[ CELL CYCLE,2015-02-15] -  Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 distinguishes their K48-ubiquitylation activities[ JOURNAL OF BIOLOGICAL CHEMISTRY,2015-01-23] -  NMR elucidation of reduced B-Z transition activity of PKZ protein kinase at high NaCl concentration[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-01-08] -  Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain[ JOURNAL OF MOLECULAR CELL BIOLOGY,2013-03-01] -  Structural alteration of Escherichia coli Hsp31 by thermal unfolding increases chaperone activity[ BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS,2013-03-01] -  Per-deuteration and NMR experiments for the backbone assignment of 62 kDa protein, Hsp31[Journal of the Korean Magnetic Resonance Society,2015-01-01] -  Oxidation-induced conformational change of Hsp33, monitored by NMR[Journal of the Korean Magnetic Resonance Society,2015-01-01]

특허(최근 5년)

-  HPr 단백질과 공동발현을 통한 LsrK 단백질 과발현 방법[2017-08-02] -  LsrR의 결정화 방법과 그 결정 및 LsrR 활성 조절제[2014-05-19] -  LsrK의 결정화 방법과 그 결정[2014-05-19]